Development of Mucoadhesive Microsphere of Quinapril Hydrochloride for Treatment of Hypertension
Abstract
Mucoadhesive drug delivery systems are very widely functional approach for delivery of system within the lumen of GIT to enhance drug absorption through the part of stomach with specific manner. Quinapril hydrochloride is the hydrochloride salt of quinapril, the ethyl ester of a non-sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat. The quinapril hydrochloride microspheres was prepared with a coat consisting of alginate polymer i.e. sodium alginate in combination of mucoadhesive polymer chitosan/ guargum by an ionic gelation process. The microspheres were evaluated for morphological character, particle size, micromeritic properties, percentage entrapment efficiency, in-vitro wash-off test and in-vitro release studies. The drug quinapril hydrochloride was study for the release over 24 h duration. The retarding nature of system maximizing the medication discharge rate at the appropriate site within specified time period for enhancing the bioavailability of drug at desired site of action to give successful treatment to the patients experiencing hypertension The drug release of the microspheres (QLMM1 – QLMM10) was slow, extended and dependent on the composition of galactomannan concentration of polymer and stirring speed during formulation used. The mucoadhesive microspheres were adhered at intestinal pH due to highly swelling nature of composition of polymers at this pH. So, increase the adhesive strength and retarded the drug release of best composition of CH:GG in the ratio of 1:3 (QLMM6). Guargum is a highly viscous material having a property of more swelling nature due to presence of galactommannan constituent. Thus, drug release from QLMM6 was slow and extended over a period of 24 h and these microcapsules were found suitable for oral controlled release formulations.
Keywords: Gastro-retentive drug delivery, Mucoadhesive microsphere, Quinapril hydrochloride, Pulsatile drug delivery system, Treatment of hypertension, Natural polymers
Keywords:
Gastro-retentive drug delivery, Mucoadhesive microsphere, Quinapril hydrochloride, Pulsatile drug delivery system, Treatment of hypertension, Natural polymersDOI
https://doi.org/10.22270/jddt.v12i3-S.5390References
Rouge N, Cole ET, Doelker E, Buri P, Buoyancy and drug release patterns of floating minutesitablets containing piretanide and atenolol as model drugs. Pharmaceutical Development and Technology; 1998; 3:73-84. https://doi.org/10.3109/10837459809028481
Ma N, Xu L, Wang Q, Zhang X, Zhang W, Li Y, Jin L, Li S, Development and evaluation of new sustained-release floating microspheres. International Journal of Pharmaceutics; 2008; 358(1-2): 82-90. https://doi.org/10.1016/j.ijpharm.2008.02.024
Garg R, Gupta GD, Progress in Controlled Gastroretentive Delivery Systems. Tropical Journal of Pharmaceutical Research; 2008; 7(3):1055-1066. https://doi.org/10.4314/tjpr.v7i3.14691
Sastry S V, Nyshadham J R, Joseph A F, Recent technological advances in oral drug delivery - a review. PSTT; 2000; 3: 138-145. https://doi.org/10.1016/S1461-5347(00)00247-9
Park K, The controlled drug delivery systems: past forward and future back. J Control Release; 2014; 190: 3-8. https://doi.org/10.1016/j.jconrel.2014.03.054
Hafeez A, Maurya A, Singh J, Mittal A, Rana L, An overview on floating microsphere: Gastro Retention Floating drug delivery system (FDDS). The Journal of Phytopharmacology; 2013; 2(3): 1-12. https://doi.org/10.31254/phyto.2013.21310
Published
Abstract Display: 390 
PDF Downloads: 351 PDF Downloads: 45 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.