An updated ethnobotany, phytochemical and pharmacological potential of Solanum indicum L.
An updated ethnobotany, phytochemical and pharmacological potential of Solanum indicum L
Abstract
Solanum indicum L. (Family Solanaceae), also known as poison berry in English, is a thorny, heavily branched perennial under shrub that can grow up to 1 metre in height and reach heights of up to 1 metre in height. This wonderful medicinal plant is extensively used in folk and traditional Indian systems of medicine to treat toxic affections, skin problems, ulcers, difficulties breathing, stomach aches, coughing, and dyspepsia, among other conditions. It is native to India and can be found throughout the country, primarily in warmer climates up to an elevation of 1500 metres. It is a well-known Indian medicinal plant that has been utilised extensively in the Ayurvedic system of medicine of treatment for many years in various ailments. It is a key component of the dasamoola group of plants' composition. Solasodine, Solasonine, Solamargine, Solanidine, and Solanine are some of the active steroidal alkaloids/glycoalkaloids found in S. indicum. The presence of various phytoconstituents in the plant has been documented, including steroidal saponins, sesquiterpenoids, hydroxycoumarins, phenolic compounds, coumarins, coumarinolignoids alkaloids, saponin, fatty acids, glycerides of the oil, and triterpenes, among other substances. Various pharmacological effects of the plant, including antibacterial, antioxidant, anthelmintic, antiplasmodial, hepatoprotective, anticancer, laxative, cardiotonic activity, CNS depressant and anti-hypertensive, hepatoprotective qualities, have been discovered in the plant. So, the aim of the present review is to provide comprehensive information from recognized sources on the ethnobotany, traditional uses, phytochemistry and pharmacological efficacy and of the medicinal plant, S. indicum. These reports are very encouraging and indicate that herb should be studied more extensively for its therapeutic benefits. Clinical trials using Solanum for a variety of combinations in different formulations should also be conducted.
Keywords: Solanum indicum, Solanaceae, ethnobotany, phytochemistry, phytopharmacology.
Keywords:
Solanum indicum, Solanaceae, ethnobotany, phytochemistry, phytopharmacologyDOI
https://doi.org/10.22270/jddt.v12i2.5385References
Dey YN, Ota S, Srikanth N., Jamal M, WanjariM. A phytopharmacological review on an important medicinal plant- Amorphophallus paeoniifolius. AYU, 2012; 33(1):27-32. https://doi.org/10.4103/0974-8520.100303
Hussain MS, Ahamed KFH, Ravichandiran V, Ansari MZH. Evaluation of in vitro free radical scavenging potential of different fractions of Hygrophila auriculata (K.Schum) Heine. Asian Journal of Traditional. Medicine. 2009a; 5(2):51-59. https://doi.org/10.4314/ijhr.v2i1.55390
Hussain MS, Ahmed KFH, Ansari MZH. Studies on diuretic activity of Hygrophila auriculata (K. Schum) Heine in rats. International Journal of Hea.th Research. 2009b; 2(1):59-64. https://doi.org/10.4314/ijhr.v2i1.55390
Hussain MS, Azam F, Ahamed KFH. Ravichandiran V and Alkskas I. Anti-endotoxin effects of terpenoids fraction from Hygrophila auriculata (K.Schum) Heine in lipopolysaccharide-induced septic shock in rats. Pharmceutical Biology. 2016; 54(4): 628- 36. https://doi.org/10.3109/13880209.2015.1070877
Hussain MS, Fareed S, Ali M. Hygrophila auriculata (K.Schum) Heine: Ethnobotany, phytochemistry and pharmacology. Asian Journal of Traditional. Medicine 2010; 5(4):122 -31.
Hussain MS, Fareed S, Ali M. Preliminary phytochemical and pharmacognostical screening of the Ayurvedic drug Hygrophila auriculata (K.Schum) Heine. Pharmacognosy Journal. 2011; (3)23:28-40. https://doi.org/10.5530/pj.2011.23.5
Hussain MS, Fareed S, Ali M. Simultaneous HPTLC-UV530nm analysis and validation of bioactive lupeol and stigmasterol in Hygrophila auriculata (K.Schum) Heine (K. Schum) Heine. Asian Pacific Journal of Tropical Biomedicine. 2012b; S612-S617. https://doi.org/10.1016/S2221-1691(12)60283-4
Hussain MS, Fareed S, Ali M. Hyphenated Chromatographic Analysis of Bioactive Gallic acid and Quercetin in Hygrophila auriculata (K.Schum) Heine (K. Schum) Heine Growing Wildly in Marshy Places in India by Validated HPTLC Method. Asian Pacific Journal of Tropical Biomedicine. 2012c; S477-S483. https://doi.org/10.1016/S2221-1691(12)60257-3
Hussain MS, Fareed S, Ansari S, Rahman MA, Ahmad IZ, Saeed M. Current approaches toward production of secondary plant metabolites. Journal of Pharmacy and Bioallied Sciences. 2012a; 4(1):10-20. https://doi.org/10.4103/0975-7406.92725
Hussain MS, Eldarrat HA, Alkskas I, Mayoof JA, Dammona JM, Ismail H, Ali M, Arif M, Haque A. Anti-inflammatory, analgesic activity and molecular docking studies of Lanostanoic acid 3-O-α-D-glycopryranoside isolated from Helichrysum stoechus against chemically challenged experimental animal. Arabian Journal of Chemistry. 2020; 13(12):9196-9206. https://doi.org/10.1016/j.arabjc.2020.11.004
Kamboj VJ. Herbal medicine. Current Science. 2000; 78(1):35-39.
Pal SK and Shukla Y. Herbal Medicine: Present and Future. Asian Pacific Journal of Cancer Prevention. 2003; 4:281-288.
Ali M, Naquvi KJ, Sultana S. Nonpolar chemical constituents from the Oryza sativa L. bran. Journal of Scientific and Innovative Research. 2014; 3(6):583-587.
Ali M, Naquvi KJ, Sultana S. New phytoconstituents from Oryza sativa L. bran. Indian Drugs. 2016; 53(9):22-26. https://doi.org/10.53879/id.53.09.10277
Iyer KN and Kolammal M. Pharmacognosy of Ayurvedic Drugs. Dept. of Pharmacognosy. Govt. Ayurveda College, Trivandrum.1960; I (4)99.
Anonymous. The Ayurvedic Pharmacopoeia of India. Govt. of India. Ministry of health and Family welfare, Dept. of ISM&H (AYUSH), New Delhi. 2001. Part-1 Vol. III. pp. 27.
Anonymous. The Wealth of India, Raw Materials, Council of Scientific and Industrial Research, New Delhi, India. 1988. Vol. IX (Rh-So).
Sarin YK. Illustrated manual of Herbal drugs used in Ayurveda, Council of Industrial and Indian Council of Medical Research. 1996.
Vaidya BCV. Some controversial drugs in Indian medicine, Chaukhamba Orientalia, Varanasi. 1982.
Sukhdev. A selection of Prime Ayurvedic Plant Drugs Ancient-Mordern concordance, Anamaya Publishers, F-154/z. lado Sarai; New Delhi, India. 2006.
Kirtikar KR and Basu BD. Indian Medicinal Plants. Vol. I. Bishen Singh Mahendra Pal Singh, Dehra Dun India. 1991.
Sivarajan VV and Balachandran I. Ayurvedic drugs and their plant sources. Oxford and IBH, New Delhi. 1994.
Bhakta T. Common Vegetables of the Tribals of Tripura. Agartala, Tripura, India. Tripura Tribal Research Institute. 2004.
Bhattacharya AS, Chiranjivi Banaushadhi. 2nd volume, 3rd reprint. Kolkata: Ananda Publishers. 1982.
Jadavji TA. Caraka Samhita of Agnivesa, Elaborated by Caraka and Drinhbala with the Ayurveda Dipika commentry by Cakrapanidatta. Chaukhambha Vidyabhawan, Varanasi. 2011.
Sharma V, Hem K, Mishra A, Maurya SK. Time tested remedies for wound care from Ayurveda sciences. Innovative Journal of Ayruvedic Sciences. 2016; 1(1-3):1-3.
Jayanthy A, Maurya A, Verma SC, Srivastava A, Shankar MB, Sharma RK. A brief review on pharmacognosy, phytochemistry and therapeutic potential of Solanum indium L. used in Indian Systems of Medicine. Asian Journal of Research Chemistry. 2016; 9(3):127-132. https://doi.org/10.5958/0974-4150.2016.00022.5
Murthy GRS, Inamdar A and Rao VS. Organographic study of vessels in some solanaceae. Phytomorphology. 1980; 149-158. https://doi.org/10.1016/S0367-2530(17)31198-2
Anjana V, Kumari NO and Mathew PM. Trichomes in some south Indian species of Solanum L. Indian Journal Botanical Research. 2005. 1(1):65-72.
Anjana VN, Kumari NO and Mathew PM. Intra-specific variations of trichomes in the genus Solanum L. Biodiversity-conservation. 2008; 109-114.
Warrier PK, Nambiar VPK and Ramankutty C. Indian medicinal Medicinal plants. A compendium of 500 species. Orient Longman. Ltd. 1996: Vol.5.
Sharma V, Hem K, Seth A, Maurya SK. Solanum indicum Linn.: An ethnopharmacological, phytochemical and pharmacological review. Current Research Journal Pharmaceutical and Allied Sciences. 2017; 1 (2):1-9.
Revathi P and Parimelazhagan T Traditional Knowledge on medicinal plants used by the Irula Tribe of Hasanur Hills, Erode District, Tamil Nadu, India. Ethno botanical Leaflets. 2010; 14:136-60.
Sultana R, Khanam S, Devi K. Immunomodulatory effect of Solanum xanthocarpum fruits. International Journal Pharmaceutical Sciences Research. 2011; 2(2):93-7.
Rahmatullah M, Das AK, Mollik MAH, Jahan R, Khan M, Rahman T, et al. An Ethnomedicinal Survey of Dhamrai Sub-district in Dhaka District, Bangladesh. American Eurasian Journal of Sustainable Agriculture. 2009a; 3(4):881-8.
Rahmatullah M, Mollik MAH, Azam ATMA, Islam MR, Mahmood MA, Chowdhury MH, et al. Ethnobotanical survey of the Santal tribe residing in Thakurgaon District, Bangladesh. American Eurasian Journal of Sustainable Agriculture. 2009b; 3(4):889-98.
Gogoi B, Zaman K. Phytochemical constituents of some medicinal plant species used in recipe during 'Bohag Bihu' in Assam. Journal Pharmacognosy Phytochemistry. 2013; 2(2):30-40.
Kumar MR, Sathyabama S, Ramathilagam RD, Priyadarisini VB. Anti-Quorum sensing activity of medicinal plants and detection of N-acyl-homoserine lactone signal molecules. International Journal of Integrative Biology. 2011; 11(1):21-5.
Kumar S, Plbag S, Maurya SK, Kumar D. Skin care in Ayurveda: A literary review. Int Res J Pharm. 2013; 4(3):1-3. https://doi.org/10.7897/2230-8407.04301
Gupta RB, Ahuja A, Sharma N, Kabra MP. Indigenous herbal plants used by tribes of Rajasthan; improving sexual performance and problem of sexuality. International Journal of Drug Development Research. 2013; 5(2):40-6.
Sathishpandiyan S, Prathap S, Vivek P, Chandran M, Bharathiraja B, Yuvaraj D, et al. Ethnobotanical study of medicinal plants used by local people in Ariyalur District, Tamilnadu, India. International Journal of Chemical Technology Research. 2014; 6(9):4276-84.
Namsa ND, Mandal M, Tangjang S. Mandal SC. Ethnobotany of the Monpa ethnic group at Arunachal Pradesh, India. Journal of Ethnobotany Ethnomedicine. 2011; 7(31):1-14. https://doi.org/10.1186/1746-4269-7-31
El-Aasr M, Miyashita H, Ikeda T, Lee JH, Yoshimitsu H, Nohara T, et al. A new spirostanol glycoside from fruits of Solanum indicum L. Chemical Pharmceutical Bulletin. 2009; 57:747-8. https://doi.org/10.1248/cpb.57.747
Yin HL, Li JH, Li B, Chen L, Li J, Tian Y, et al. Two new coumarins from the seeds of Solanum indicum. Journal of Asian Natural Product Research. 2014; 16(2): 153-7. https://doi.org/10.1080/10286020.2013.841142
Huang WH, Hsu CW, Fang JT. Central diabetes insipidus following digestion Solanum indicum L. concentrated solution. Clinical Toxicology (Phila). 2008; 46(4):293-6. https://doi.org/10.1080/15563650701385881
Deb PK, Ghosh R, Chakraverty R, Debnath R, Lakshman Das L and Bhakta T. Phytochemical and Pharmacological Evaluation of Fruits of Sola numindi cum Linn. International Journal of Pharmaceutical Sciences Review Research. 2014: 25(2).
Krishnaveni A, Selvi BK, Maheswari RU, Jayanthi B and Maheswari DU. Antibacterial activity of fruit extracts of Solanum indicum. Indian Journal of Natural Products. 2005; 21(4):58-59.
Gavimath CC, Kulkarni SM, Raorane CJ, Kalsekar DP, Gavade BG, Ravishankar BE and Hooli RS. Antibacterial potentials of Solanum indicum, Solanum xanthocarpum and Physalis minima. International Journal of Pharmaceutical Application. 2012; 3(4):414-418.
Jayanthy A, Sulaiman CT and Rema Shree AB. Pharmacognostical and Phytochemical Comparison of Roots of Solanum species used in Ayurvedic Formulations. Proceedings of Second National Seminar on Genetics, Breeding and Biotechnology. Interuniversity Centre for Plant Biotechnology, Dept. of Botany, University of Calicut. 2011; 22.
Srividya AR, Arunkumar A, Cherian B, Maheshwari V, Piramanayagam S, Senthoorpandi V. Pharmacognostic, phytochemical and antimicrobial studies of Solanum indicum leaves. Anc Science Life. 2009; 29(1):3-5.
Kouadio AI, Chatigre OK, Dosso MB. Phytochemical screening of the antimicrobial fraction of Solanum indicum L. berries extract and evaluation of its effect against the survival of bacteria pathogens of plants. International J of Biotechnology Food Sciences. 2014; 2(1):21-30.
Kouadio AI, Oulahal N, Thi PN, Adt I, Degraeve P. Study of the antimicrobial activities of Solanum indicum ssp. Distichum (Schumach. and Thonning 1827) fruits ("gnangnan" berries) from a tropical humid zone (Côte d'Ivoire). International Journal Biology Chemical Sciences. 2011; 5(3):1190-200. https://doi.org/10.4314/ijbcs.v5i3.72254
Deb PK, Das N, Bhakta RGT. Evaluation of in-vitro Antioxidant and Anthelmintic Activity of Solanum indicum Linn. Berries. Indo American Journal of Pharmaceutical Research. 2013a; 3(2):4123-30.
Hasan RU, Prabhat P, Shafaat K, Khan R. Phytochemical investigation and evaluation of antioxidant activity of fruit of Solanum indicum Linn. International Journal of Pharmacy and Pharmceutical Sciences. 2013; 5(3):237-42.
N'dri D, Calani L, Mazzeo T, Scazzina F, Rinaldi M, Rio DD, Pellegrini N, et al. Effects of different maturity stages on antioxidant content of Ivorian Gnagnan (Solanum indicum L.) berries. Molecules. 2010; 15(10):7125-38. https://doi.org/10.3390/molecules15107125
Bhuvaneswari B, Suguna MML. Hepatoprotective and antioxidant activities of Solanum indicum Linn. Berries. International Journal of Clinical Toxicology. 2014; 2:71-6. https://doi.org/10.14205/2310-4007.2014.02.02.4
Narayanaswamy N, Balakrishnan KP. Evaluation of some Medicinal Plants for their Antioxidant Properties. International Journal of Pharmaceutical Technology and Research. 2011; 3(1):381-5.
Senaratne UVR, Perera HKI, Manamperiand A, Athauda SBP. Partial purification of anthelmintic compounds from Solanum indicum. Proceedings of the Peradeniya University Research Sessions, Sri Lanka. 2011; 16.
Anwikar S, Bhitre M. Study of the synergistic anti-inflammatory activity of Solanum xanthocarpum Schrad and Wendl and Cassia fistula Linn. International Journal of Ayurveda Research. 2010; 1(3):167-71. https://doi.org/10.4103/0974-7788.72489
Zirihi GN, Mambu L, Guédé-Guina F, Bodo B, Grellier P. In-vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. Journal of Ethnopharmacology. 2005; 98(3):281-5. https://doi.org/10.1016/j.jep.2005.01.004
Ghassam BJ, Ghaffari H, Prakash HS, Kini KR. Antioxidant and hepatoprotective effects of Solanum xanthocarpum leaf extracts against CCl4-induced liver injury in rats. Pharmceutical Biology. 2014; 52(8):1060-8. https://doi.org/10.3109/13880209.2013.877490
Syu W, Don M, Lee G, Sun C. Cytotoxic and novel compounds from Solanum indicum. Journal of Natural Products. 2001; 64(9): 1232-3. https://doi.org/10.1021/np010186v
Chiang HC, Tseng TH, Wang CJ, Chen CF, Kan WS. Experimental antitumor agents from Solanum indicum L. Anticancer Research. 1991; 11(5):1911-7.
Gopalakrishna SM, Thimappa GS, Thylur RP, Shivanna Y, Sreenivasan A. In-vitro anti-cancer screening of Solanum indicum Rhus succedanea, Rheum emodi and Gardenia gummifera medicinal plants in cancer cells. Research Review Journal of Pharmaceutical Sciences. 2014; 3(4):22-30.
Rahman MS, Begum B, Chowdhury R, Rahman MK, Rashid MA. Preliminary Cytotoxicity Screening of Some Medicinal Plants of Bangladesh. Dhaka University Journal of Pharmceutical Sciences. 2008; 7(1):47-52. https://doi.org/10.3329/dujps.v7i1.1217
Deb PK, Das L, Ghosh R, Debnath R, Bhakta T. Evaluation of laxative and cardiotonic activity of Solanum indicum Linn fruits. Journal of Pharmacy and Phytotherapy. 2013b; 1: 3:11-4.
Deb PK, Ghosh R, Chakraverty R, Debnath R, Lakshman Das L and Tejendra Bhakta T. Phytochemical and Pharmacological Evaluation of Fruits of Sola numindi cum Linn. International Journal of Pharmceutical Sciences Review Research. 2014: 25(2):11-4.
Parle M, Singh N. Reversal of memory deficits by atorvastatin and simvastatin in rats. Yakugaku Zaashi, 2007; 127: 1125-1137. https://doi.org/10.1248/yakushi.127.1125
Abeer YI, Nermeen M S. Protective Effect of Solanum indicum Var. Distichum extract on experimentally induced gastric ulcers in rat. Global Journal of Pharmacology. 2013; 7 (3):325-32.
Al-Oqail HM, Hassan WHB, Ahmad MS, Al-Rehaily AJ. Phytochemical and biological studies of Solanum schimperianum. Saudi Pharmceutical Journal. 2012; 20:371-9. https://doi.org/10.1016/j.jsps.2012.05.010
Asha VV, Pushpangadan P. Preliminary evaluation of the antihepatotoxic activity of Phyllanthus kozhikodianus, P. maderaspatens is and Solanum indicum. Fitoterapia. 1998; 69(3):255-259.
Bahgat A, Abdel-Aziz H, Raafat M, Mahdy A, El-Khatib AS, Ismail A, et al. Solanum indicum ssp. distichum extract is effective against LNAME- induced hypertension in rats. Fundamental & Clinical Pharmacology. 2008; 22(6):693-9. https://doi.org/10.1111/j.1472-8206.2008.00627.x
Yahara S, Nakamura T, Someya Y, Matsumoto T, Yamashita T, Nohara T. Steroidal glycosides indiosides A-E, from Solanum indicum. Phytochemistry. 1996; 43(6):1319-23. https://doi.org/10.1016/S0031-9422(96)00395-0
Kirtikar KR, Basu BD, Indian Medicinal Plants, 2nd ed. Vol. II. International Book Publication Distribution, Dehradun, India, 1995; 1755-7.
Chopra RN, Nayer SL, Chopra IC. Glossary of Indian Medicinal Plants. New Delhi: PID, CSIR. 1992.
Khare CP. Indian Medicinal Plants-An Illustrated Dictionary. First Indian Reprint, Springer (India) Pvt. Ltd. New Delhi. 2007. https://doi.org/10.1007/978-0-387-70638-2
Puntambekar SV, Krishna S. Fatty oil from the seeds of Solanum indicum Linn. Journal Indian Chemical Society. 1941; 18:329-34.
Yin HL, Li JH, Li J, Li B, Chen L, Tian Y, et al. Four new coumarinolignoids from seeds of Solanum indicum. Fitoterapia. 2013; 84360-5. https://doi.org/10.1016/j.fitote.2012.09.002
Bhattacharya AS, Chiranjivi Banaushadhi. 2nd volume, 3rd reprint. Kolkata: Ananda Publishers. 1982.
Jaiswal V, Singh SK, Singh AK, Maurya SK. A critical review on antiasthmatic Ayurvedic medicinal plants and compound Formulations. International Journal of Pharmacy Archive. 2014; 3(5):400-9.
Gu G, Du Y, Linhardt RJ. Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors. Journal of Organic Chemistry. 2004; 69(16): 5497-500. https://doi.org/10.1021/jo0493929
Gopalakrishna SM, Thimappa GS, Thylur RP, Shivanna Y, Sreenivasan A. In- vitro Anti-Cancer Screening of Solanum indicum Rhus succedanea, Rheum emodi and Gardenia gummifera Medicinal Plants in Cancer Cells. Research Review Journal of Pharmaceutical Sciences. 2014; 3(4):22-30.
Mishra A, Seth A, Maurya SK. Therapeutic significance and pharmacological activities of Antidiarrhoeal medicinal plants mention in Ayurveda: A review. Journal of Intercultural Ethnopharmacology. 2016; 5(3):290-307. https://doi.org/10.5455/jice.20160426094553
Mishra A, Sharma V, Hem K, Maurya SK. Plants used for treatment of diarrhea: an Ayurvedic prospective. Innovative Journal of Ayruvedic Sciences. 2015; 3(1):1-6.
Malhotra SR, Kumar D. Euphorbia hirta: Its chemistry, traditional and medicinal uses, and pharmacological activities. Pharmacognosy Review. 2010; 4(7):58-61. https://doi.org/10.4103/0973-7847.65327
Maurya SK, Seth A, Gautam DNS, Singh AK. Biodiversity and indigenous uses of medicinal plant in the Chandra Prabha Wildlife Sanctuary, Chandauli District, Uttar Pradesh. International Journal of Biodiversity. 2015; 2015:394307. https://doi.org/10.1155/2015/394307
Maurya SK, Seth A. Potential medicinal plants and traditional Ayurvedic approach towards urticaria, An allergic skin disorder. International Journal of Pharmceutical Sci. 2014; 6(5):172-7.
Published



How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).