Oral Dissolving Films: A Comprehensive Review on Recent Perspectives and Current Approach to Effective Drug Delivery
Abstract
Oral dissolving films are advanced oral dosage forms implied for the attachment onto the buccal mucosa and have both local and systemic effects. These dosage forms may be favored over other oral drug delivery systems in terms of flexibility and comfort. These films utilize the property of bioadhesion of certain polymers, which on hydration target a particular region of the body for extended period of time thereby bypassing first pass metabolism and promoting increased bioavailability. These films are self-administrable, pharmacoeconomic and have good patient compliance. Various techniques may be used for the formulation of oral dissolving films, among which solvent casting method is the most preferable. Usually hydrophilic polymers along with other excipients are used to formulate buccal films, which disintegrate quickly releasing the incorporated APIs within seconds. Oral dissolving films offer numerous benefits as far as accessibility, administration and withdrawal, retentivity, low enzymatic movement, economy and high patient compliance is concerned, thus having the potential for market and business exploitation. This preset review emphasizes on mechanism of action, merits, composition, formulation, evaluation, marketed formulations of oral dissolving films. Additionally, covering the aspects related to novel fast dissolving techniques.
Keywords: Solvent casting method, buccal films, bioadhesion, hydration, bioavailability.
Keywords:
Solvent casting method, buccal films, bioadhesion, hydration, bioavailabilityDOI
https://doi.org/10.22270/jddt.v12i2.5244References
Akbari J, Nokhodchi A, Farid D, Adrangui M, Siahi-Shadbad MR, Development and evaluation of buccoadhesive propranolol hydrochloride table formulations: Effect of fillers, Farmaco 59: 155-161. DOI: https://doi.org/10.1016/j.farmac.2003.11.011.
Rathborne M, Drummond B, Tucker I, Oral cavity as a site for Systemic drug delivery, Adv Drug Deliv Rev 13: 1-22. DOI:10.1016/0169-409X(94)90024-8.
Venkat S, Mucoadhesive films: An over review, Asian Journal of Science and Technology, 2017; 8:4790–4802.
Harris D, Robinson JR, Drug delivery via the mucous membranes of the oral cavity, J. Pharm. Sci, 1992; 81:1–10. DOI: 10.1002/jps.2600810102.
Ehtezazi T, Algellay M, Islam Y, Roberts M, Dempster NM, Sarker SD, The Application of 3D Printing in the Formulation of Multilayered Fast Dissolving Oral Films, J Pharm. Sci., 2018; 107(4):1076–1085. DOI: 10.1016/j.xphs.2017.11.019.
Wertz PW, Squier CA, Cellular and molecular basis of barrier function in oral epithelium, Crit. Rev. Ther. Drug Carr. Sys., 1991; 8:237-269.
Patel KV, Patel ND, Dodiya HD, Shelat PK, Buccal bioadhesive drug delivery system: An Overview, Int J Pharm Bio Arch 2011; 2(2):600-9.
Gupta SK, Singhavi IJ, Shirsat M, Karwani G, Agrawal A, Buccal adhesive drug delivery system: A Review, Asian Journal of Biochemical and pharmaceutical research, 2011; 2(1):105-114.
Lee JW, Park J, Robinson J, Bioadhesive-based dosage forms: the next generation, J Pharm Sci., 2000; 89(7):850-66. DOI: 10.1002/1520-6017(200007)89:7<850::AID-JPS2>3.0.CO;2-G.
Miller NS, Johnston TP, The use of mucoadhesive polymers in buccal drug delivery, Advanced Drug Delivery, Rev 2005; 57:1666–91. DOI: 10.1016/j.addr.2005.07.003.
Hussain MW, Kushwaha P, Rahman MA, Akhtar J, Development and Evaluation of Fast Dissolving Film for Oro-Buccal Drug Delivery of Chlorpromazine, Indian Journal of Pharmaceutical Education and Research, 2017; 51:S539-S547. DOI:10.5530/ijper.51.4s.81.
Shojaei Amir H, Buccal Mucosa as A Route for Systemic Drug Delivery: A Review, J Pharm Pharmaceutical Sci., 1998; 1 (1):15-30.
Niyaz USH, Elango K, Oral fast dissolving films: An innovative drug delivery system, World Journal of Pharmacy and Pharmaceutical Sciences. 2018; 7:881-907.
Dixit RP, Puthli SP, Oral strip technology: Overview and future potential, Journal of Controlled Release, 2009; 139:94–97. DOI:10.1016/j.jconrel.2009.06.014.
Patil P, Shrivastava, Fast Dissolving Oral Films: An Innovative Drug Delivery System, International Journal of Science and Research, July 2014; 3(7)2088-2093.
Jain A, Harish C, Ahirwar, Tayal S, Mohanty PK, Fast Dissolving Oral Films: A Tabular Update, J. Drug Delivery and Therapeutics, 2018; 8 (4):10-19. DOI: https://doi.org/10.22270/jddt.v8i4.1724.
Patil BS, Tate SS, Kulkarni U, Hari Prasanna RC and Wadageri GV, Development and In-vitro evaluation of mucoadhesive buccal tablets of Tizanidine hydrochloride using natural polymer Xanthan gum, Inter. J. Pharm. Sci. Rev. and Res., 2011; 8(2):140-146.
Khatoon N, Raghavendra Rao NG, Reddy BM, Overview on Fast Dissolving Oral Films, International Journal of Pharmaceutical Sciences and Drug Research, 2013; 1(1):63-75. DOI: https://doi.org/10.25004/IJPSDR.2016.080101.
Kulkarni AS, Deokule HA, Mane MS, Ghadge DM, Exploration of different polymers for use in the formulation of oral fast dissolving strips, J. Current Pharmaceutical Res., 2010; 2(1):33-35.
Murthy AV, Ayalasomayajula LU, Earle RR, Jyotsna P, Formulation and Evaluation of Tramadol Hydrochloride Oral Thin Films, IJPSR, 2018; 9:1692-1698. DOI: 10.13040/IJPSR.0975-8232.9(4).1692-98.
Rajat P, Ravi S, Pravin S, Darwhekar GN, A Review on Mouth Dissolving Film, 2019; 9(6):206–10. DOI: 10.22270/jddt.v9i6.3676.
Sau-hung S, Robert S, Lori, Fast dissolving orally consumable films, U.S. Patent 6, 596, 298.
Prakash I, DuBois GE, Clos JF, Wilkens KL, Fosdick LE, Development of rebiana, a natural, non-caloric sweetener, Food and Chemical Toxico, 46(S2):S75-S82. DOI: 10.1016/j.fct.2008.05.004.
Israel K, Leo M, Salivary stimulant, U.S Patent, 1989; 4820506.
http://www. Patent storm.us /patents/ 6740332/claims. Html.
Chapdelaine AH, Zyck DJ, Dzija M, Edible film formulations containing maltodextrin, US Patent, 2009.
Technical Brief: Particle Sciences Drug Development Services, Vol 3 2010.
Coppens KA, Hall MJ, Mitchell SA, Read MD, Hypromellose, Ethyl cellulose and Polyethylene oxide used in hot melt extrusion, Pharmaceutical Technol., 2005; pp: 1-6.
Mahesh A, Shastri N, Sadanandam M, Development of Taste Masked Fast Disintegrating Films of Levocetirizine Dihydrochloride for Oral Use, Current Drug Delivery, 2010; 7(1):21-27. DOI: 10.2174/156720110790396454.
Devaraj H, Venkatachalam S, Radhakrishnan A, Research Article A Review on Formulation of Oral Dissolving Film, 2018; 10(4):151–9. DOI: 10.35629/7781-0603370378.
Cilurzo F, Cupone IE, Minghetti P, Selmin F, Montanari L, Fast dissolving films made of maltodextrins, European Journal of Pharmaceutics and Biopharmaceutics, 2008; 70: 895-900. DOI: 10.1016/j.ejpb.2008.06.032.
Frey, Film Strips and Pharmaceuticals, Pharmaceutical Manufacturing and Packaging Sources, 2006; pp: 92-93.
Bilal Q, Unhale SS, A review on mouth dissolving films, 2020; ( March).
Elsayed, I, EL- Dahmy RM, Elshafeey AH, Gawad EL, Gazayerly EL, Tripling the bioavailability of rosuvastatin calcium through development and optimization of an in situ forming nanovesicular system, Pharmaceutics, 2019, Jun 11; 11(6):275. DOI: 10.3390/pharmaceutics11060275.
Niyaz U, Elango K., Oral Fast Dissolving Films: An Innovative Drug Delivery System, World Journal of Pharm. and Pharmaceutical Sci., 2018; 7(11):881-907. DOI: 10.4274/tjps.galenos.2020.76390.
Ammar HO, Ghorab MM, Mahmoud AA, Shahin HI, Design and In Vitro/ In Vivo Evaluation of Ultra-Thin Mucoadhesive Buccal Film Containing Fluticasone Propionate, AAPS PharmSciTech. 2017; 18:93-103. DOI: 10.1208/s12249-016-0496-0.
Bala R, Sharma S, Formulation optimization and evaluation of fast dissolving film of aprepitant by using design of experiment Bulletin of Faculty of Pharmacy, Cairo University, 2018; 56(2):159-158. DOI: 10.1016/J.BFOPCU.2018.04.002.
Chavan DU, Marques SM, Bhide PJ, Kumar L, Shirodkar RK, Rapidly dissolving Felodipine nanoparticle strips: Formulation using design of experiment and characterization, J. Drug Deliv. Sci. Technol., 2020, 60, 102053.
Bharti K, Mittal P, Mishra B, Formulation and characterization of fast dissolving oral films containing buspirone hydrochloride nanoparticles using design of experiment, J. Drug Deliv. Sci. Technol., 2019, 49, 420–432. DOI:10.1016/J.JDDST.2018.12.013.
Naik S, Hemanth H, Vageesh N, Basavaraju K, Formulation and in vitro evaluation of rizatriptan benzoate oral disinetgrating film, Innovat International Journal Of Medical & Pharmaceutical Sciences, 2018; 3(1). DOI: 10.24018/10.24018/iijmps.2018.v1i1.22
Reddy Usha Kiran T, Reddy Sunil Kumar K, Manogna Katta, Prof. Thyagaraju K, A detailed review on fast dissolving oral films, Indo- American Journal of Pharmaceutical Research, 2018; 8(6):1315- 1326.
Kumar RS, Yagnesh Naga Satya T, Oral dissolving films: an effective tool for fast therapeutic action, Journal of Drug Delivery and Ther., 2019; 9(1-s): 492-490. DOI: https://doi.org/10.22270/jddt.v9i1-s.2395.
Wasilewska K, Winnicka K, How to assess orodispersible film quality? A review of applied methods and their modifications, Acta Pharmaceutica, 2019; 69:155-176.
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