Article Reviewing Transdermal Drug Delivery System

Authors

  • Ankita Soni Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India
  • J.S. Dua Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India
  • D.N. Prasad Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Punjab, India

Abstract

Topically applied pharmaceuticals in the form of patches that distribute medications for systemic effects at predefined and controlled rates are known as "transdermal drug delivery systems." The main function of TDDS is penetration of drug through skin. It works extremely simple, with the medicine being put within the patch and is placed on the skin. As a result, a consistent concentration of medication remains in the bloodstream for an extended period. They come in variety of forms, including single-layer drugs in adhesives; inter drugs in adhesives, buffers, and matrix systems. The market price of TDDS products is rapidly expanding. More than 35 items have now been authorized for sale in the United States, and roughly 16 active substances have been approved for usage as a TDDS globally. It is a drug delivery system that has a bright future. It helps in reducing use of syringes for administering a wide range of drugs, but the price is an essential aspect to consider because developing countries like India have the world's second-largest population, but TDDS is a secret part of treatment used for the general population due to rising costs. This review article on transdermal drug delivery systems (TDDS) contains information on the transdermal drug delivery system, Advanced development and the evaluation procedure.

Keywords: TDDS, Drug penetration, Bright future, Rising costs, Evaluation procedure.

Keywords:

TDDS, Drug penetration, Bright future, Rising costs, Evaluation procedure

DOI

https://doi.org/10.22270/jddt.v12i1.5159

Author Biographies

Ankita Soni, Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India

Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India

J.S. Dua, Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India

Department of Pharmaceutics, Shivalik College of Pharmacy, Nangal, Punjab, India

D.N. Prasad, Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Punjab, India

Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Punjab, India

References

Han, T.; Das, D.B. Potential of Combined Ultrasound and Microneedles for Enhanced Transdermal Drug Permeation: A Review. Eur. J. Pharm. Biopharm. 2015; 89:312-328. https://doi.org/10.1016/j.ejpb.2014.12.020

Schoellhammer, C.M.; Blankschtein, D.; Langer, R. Skin Permeabilization for Transdermal Drug Delivery: Recent Advances and Future Prospects. Expert Opin. Drug Deliv. 2014; 11:393-407. https://doi.org/10.1517/17425247.2014.875528

Donnelly, R.F.; Singh, T.R.R.; Morrow, D.I.; Woolfson, A.D. Microneedle-Mediated Transdermal and Intradermal Drug Delivery; Wiley: Hoboken, NJ, USA, 2012. https://doi.org/10.1002/9781119959687

Kretsos, K.; Kasting, G.B. A Geometrical Model of Dermal Capillary Clearance. Math. Biosci. 2007; 208:430-453. https://doi.org/10.1016/j.mbs.2006.10.012

Prausnitz, M.R.; Langer, R. Transdermal Drug Delivery. Nat. Biotechnol. 2008; 26:1261-1268. https://doi.org/10.1038/nbt.1504

Waghule T, Singhvi G, Dubey SK, Pandey MM, et al. Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomed Pharmacother. 2019; 109:1249-1258. https://doi.org/10.1016/j.biopha.2018.10.078

Rai VK, Mishra N, Yadav KS, Yadav NP. Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: Formulation development, stability issues, basic considerations and applications. J Controlled Release. 2018; 270:203-225. https://doi.org/10.1016/j.jconrel.2017.11.049

Kathe K, Kathpalia H. Film forming systems for topical and transdermal drug delivery. Asian J Pharm Sci. 2017; 12:487-497. https://doi.org/10.1016/j.ajps.2017.07.004

Kim H, Kim JT, Barua S, Yoo SY, et al. Seeking better topical delivery technologies of moisturizing agents for enhanced skin moisturization. Expert Opin Drug Delivery. 2018; 15:17-31. https://doi.org/10.1080/17425247.2017.1306054

Barua S, Lee DI, Kim H, Jo K, Yeo S, et al. Solid Lipid Nanoparticles of Serine Designed by Evaluating Affinity of Solid Lipids to Stratum Corneum for Enhanced Skin Hydration in Combination with Reed Root Extract. Bull Korean Chem Soc. 2018; 39:220- 226. https://doi.org/10.1002/bkcs.11371

Engelke L, Winter G, Engert J. Application of water-soluble polyvinyl alcohol-based film patches on laser microporated skin facilitates intradermal macromolecule and nanoparticle delivery. Eur J Pharm Biopharm. 2018; 128:119-130. https://doi.org/10.1016/j.ejpb.2018.04.008

Karbhari V N, Tanuja W. Transdermal drug delivery system: A review. World J Pharm Res. 2016; 5(9):1733-42.

Sharma N. A brief review on transdermal patches. Org. Medi Chem Int. J. 2018; 7(2):01-5.

Jain NK, Controlled and novel drug delivery. 1st Ed., CBS Publisher and Distributors, New Delhi. 2001; 100-129.

Robinson JR, Lee VH. Controlled drug delivery fundamentals and applications. 2nd Ed. New York. 2005; 523-536.

Wilson R, Waugh A, Grant A. Anatomy and physiology in health and illness. 9th Ed. 2001;363-366.

Jain NK. Pharmaceutical product development. 1st Ed. CBS Publisher and Distributors. New Delhi. 2002; 221-228.

Kumar D, Sharma N, Rana AC, Agarwal G, Bhat ZA. A review: transdermal drug delivery system: a

tools for novel drug delivery sestem. Int. J Drug Dev. Res. 2011; 3(3):70-84.

Hans Schaefer, Thomas E. Redelmeier. Skin Penetration. Chapter 11; 2020:167-176. https://doi.org/10.1007/3-540-31301-X_11

Chauhan N, Kumar K, Pant NC. An updated review on transfersomes: a novel vesicular system for transdermal drug delivery. Universal Journal of Pharmaceutical Research 2017; 2(4):42-45. https://doi.org/10.22270/ujpr.v2i4.RW2

Rhaghuram reddy k, Muttalik S and Reddy S. Once- daily sustained- release matrix tablets of nicorandil: formulation and invitro evaluation. AAPS Pharm.Sci.Tech. 2003; 4:4. https://doi.org/10.1208/pt040461

Shaila L, Pandey S and Udupa N. Design and evaluation of matrix type membrane controlled Transdermal drug delivery system of nicotin suitable for use in smoking cessation. Indian Journ. Pharm.Sci. 2006; 68:179-184 https://doi.org/10.4103/0250-474X.25711

Umar S, Onyekachi MK. Development and evaluation of transdermal gel of Lornoxicam. Universal Journal of Pharmaceutical Research. 2017; 2(1):15-18. https://doi.org/10.22270/ujpr.v2i1.R4

Baghel S, Naved T, Parvez N. Formulation and development of transdermal drug delivery system of ethinylestradiol and testosterone: in vitro evaluation. Int J App Pharm. 2019; 11(1):55-60. https://doi.org/10.22159/ijap.2019v11i1.28564

Jafri I, ShoaibMH, Yousuf RI, Ali FR. Effect of permeation enhancers on in vitro release and transdermal delivery of lamotrigine from Eudragit®RS100 polymer matrix type drug in adhesive patches. Progress in Biomaterials. 2019; 8:91- 100. https://doi.org/10.1007/s40204-019-0114-9

Kharia A, Gilhotra R, Singhai AK. Formulation and evaluation of transdermal patch for treatment of inflammation. International Journal of Pharmaceutical Sciences and Research. 2019; 10(5):2375-2384.

Fatima AA, Chukwuka UK. Development and in-vitro evaluation of matrix-type transdermal patches of losartan potassium. Universal Journal of Pharmaceutical Research. 2017; 2(2):16-20. https://doi.org/10.22270/ujpr.v2i2.R5

Aarti N, Louk A.R.M.P, Russsel.O.P and Richard H.G. Mechanism of oleic acid induced skin permeation enhancement in vivo in humans. Jour.control. Release. 1995; 37:299-306. https://doi.org/10.1016/0168-3659(95)00088-7

Singh DP, Sahu P. Pharmacology and Chemistry of Garlic. Advanced Journal of Bioactive Molecules.2020; 1(1):9-16.

Dewangan A, Sahu BP, Meher B. Review on Pharmacological Potential of Ocimum sanctum L. Advanced Journal of Bioactive Molecules.2020; 1(1):17-24.

Thakur M, Gupta PP, Roy A, Chandrakar S, Sahu J, Gupta PU. Therapeutic Potential of Plumeria Rubra Plant: A Review. Advanced Journal of Bioactive Molecules. 2021; 1(2).

Patel D, Sunita A, Parmar B, Bhura N, Transdermal Drug Delivery System: A Review, the Pharma Innovation. 2012; 1(4):66-75. https://doi.org/10.31638/IJPRS.V1.I1.00018

Shingade GM, Aamer Q, Sabale PM, Gramprohit ND, Gadhave MV, Jadhv SL, Gaikwad DD, Review on: recent trend on transdermal drug delivery system, Journal of Drug Delivery & Therapeutics. 2012; 2 (1):66-75 https://doi.org/10.22270/jddt.v2i1.74

Rathor S, Ram A. Advancement in transdermal drug delivery system: Microneedles. Asian J Pharm Res Dev. 2017; 5:1-7

Published

2022-01-15
Statistics
Abstract Display: 1999
PDF Downloads: 1538
PDF Downloads: 124

How to Cite

1.
Soni A, Dua J, Prasad D. Article Reviewing Transdermal Drug Delivery System. J. Drug Delivery Ther. [Internet]. 2022 Jan. 15 [cited 2026 Feb. 2];12(1):176-80. Available from: https://www.jddtonline.info/index.php/jddt/article/view/5159

How to Cite

1.
Soni A, Dua J, Prasad D. Article Reviewing Transdermal Drug Delivery System. J. Drug Delivery Ther. [Internet]. 2022 Jan. 15 [cited 2026 Feb. 2];12(1):176-80. Available from: https://www.jddtonline.info/index.php/jddt/article/view/5159

Most read articles by the same author(s)

> >>