Evaluation of Anthelmintic Activity of Calendula officinalis Flowers Extract
Abstract
Background: The present study is an attempt to explore the anthelmintic activity of ethanolic extract of flower of Calendula officinalis. Various doses of ethanolic extracts were evaluated for their anthelmintic activity on adult Indian earthworms, Pheretima posthuma. Calendula officinalis Linn has been widely used in homeopathic medicine for the treatment of many diseases. It has been reported to possess many pharmacological activities, which include antibacterial, antifungal, antiviral,antioxidant and anti-inflammatory.
Methods: The ethanol extract of air dried flowers powder (500g) was prepared by using soxlet apparatus, concentrated and vacuum dried which gave an orange yellowish mass (60.46 g). Extract was subjected to qualitative chemical investigation of phytoconstituents such as glycosides, alkaloids, flavonoids, carbohydrates, tannins, proteins, vitamins, coumarins etc.
Results: All extracts were able to show anthelmintic activity at 10mg/mL concentration. The activities are comparable with the standard drugs, piperazine citrate and albendazole. The data were found statistically significantly by using one way Anova at 5% level of significance (p< 0.05).
Conclusion: All the doses of ethanolic extract of calendula officinalis showed dose dependent anthelmintic activity in comparison to standard drugs.
Keywords: Calendula officinalis, Asteraceae, Anthelmintic, Piperazine citrate, Albendazole
Keywords:
Calendula officinalis, Asteraceae, Anthelmintic, Piperazine citrate, AlbendazoleDOI
https://doi.org/10.22270/jddt.v11i4.4944References
2. Nadembega P, Boussim IJ, Nikiema BJ, Poli F, Antognoni F, "Medicinal plants in Baskoure, Kourittenga Province, Burkina Faso: An Ethnobotan. Study" Ethanopharmacology, 2011; 133:378- 395. https://doi.org/10.1016/j.jep.2010.10.010
3. Hoareau L, Dasilva JE, "A re-emerging health aid, EJB Electron Biotechnology" Medicinal plants, 1999; 2:56-70. https://doi.org/10.2225/vol2-issue2-fulltext-2
4. Rihawy S M, Bakraji H E, Aref S, Shaban R, "Elemental investigation of Syrian Medicinal plants using PIXE Analysis" Nuclear Instruments and methods in Physics Research Biotechnology, 2010; 268:2790-2793. https://doi.org/10.1016/j.nimb.2010.06.034
5. Prashant K V, Chauhan SN, Padh H, Rajani M, "Review on Pharmacological Update: Calendula officinalis .Linn" Ethnopharmacology, 2006; 107:182 - 188. https://doi.org/10.1016/j.jep.2006.03.013
6. Dhar L M, Dhar M M, Dhawan B N, Mehrotra B N, Ray C, "Screening of Indian Plants for Biological activity" Experimental biology, 1968; 6:232-247.
7. Chakraborthy G.S. "phytochemical screening of calendula officinalis linn "International journal of research in Ayurveda and pharmacy" 2010; 1(1):131-134
8. Harborn J. B, "Phytochemical methods, 3rd edition Chapman and Hall, London", (1988), pp.117-119.
9. Vidyarthi R. D, "A Textbook of Zoology", Chand and Co.Press, New Delhi, 14th edition, 1977, 329.
10. Thron G. W, "Harrison's Principles of Internal Medicine" Mc Grew Hill, New York, 1977, 1088.
11. Vigar Z, "Atlas of Medicinal Parasitology", Publishing House, Singapore, 2nd ed., 1984, 216.
12. Ansari S. H, Alam k. and Pathak D, "Evaluation of Anthelmintic activity of Adhatoda zeylanica Medic. Leaves extract" Indian Drugs, 2010; 47(10):55.
13. Bolton S. "In: Pharmaceutical Statistics-Practical and Clinical Applications" Marcel Dekker, New York, 1997, 69
14. Rang H. P. and Dale M. M, "Textbook of Pharmacology" Churchill Livingstone, Elsevier, 6th ed., 2007, 712. https://doi.org/10.1016/B978-0-443-06911-6.50055-4
15. Tripathi K. D, "Essential of Pharmacology" Jaypee Brothers Medical Publishers (P) LTD, 6thedition 2008, 808.
Published
Abstract Display: 834 
PDF Downloads: 813 PDF Downloads: 104 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.