Integration of Complementary and Alternative Medicines in Health care system to combat COVID 19- A Validation
Abstract
Human mankind has always been under the wrath of various epidemics viz. Spanish Flu, Asian Flu, Hong Kong Flu, influenza A-H1N1 virus, SARS in 2003, etc. The on-going COVID 19 pandemic has posed as a serious concern to humans with no proper treatment and no specific drugs against this virus. There have been various challenges to the current health care delivery system. There is dearth of reported RCTs evaluating effects of antivirals. Corticosteroid treatment has reported to have delayed coronavirus RNA clearance with its widespread use leading to development/exacerbation of fungal diseases like Mucormycosis. Various vaccines designed have many questions about their efficacy that may rise with time, as SARS-CoV-2 has numerous variants, and it can mutate over time. With limited success in developing antivirals, Complementary and Alternative medicines like Traditional Chinese medicines, Ayurvedic and homoeopathic medicines have been gaining momentums in recent years displaying promising results. Methodical researches are warranted to further evaluate the efficacy of Complementary and alternative medicines. For curtailing the devastating effects of COVID 19 requires reviewing the current health policies by integrating complementary medicine with conventional system. To channelize all the available therapeutic options to win the battle against COVID-19 is the need of hour.
Keywords:
Ayurved, Complementary and alternative medicines, COVID-19, Homoeopathy SARS-CoV-2, Traditional Chinese medicinesDOI
https://doi.org/10.22270/jddt.v11i4.4932References
Fields, Bernard N, David M. Knipe, and Peter M. Howley. Fields Virology. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2007. Print.
Woolhouse M, Scott F, Hudson Z, Howey R, Chase-Topping M. Human viruses: discovery and emergence. Philos Trans R Soc Lond B Biol Sci. 2012 Oct 19; 367(1604):2864-71. doi: 10.1098/rstb.2011.0354. PMID: 22966141; PMCID: PMC3427559. https://doi.org/10.1098/rstb.2011.0354
World Health Organization/Europe. Past pandemics. [Internet]. Europe. WHO/Europe. [cited on 10.05.2021]. Available from: https://www.euro.who.int/en/health-topics/communicable-diseases/influenza/publications.
Chew SK. SARS: how a global epidemic was stopped. Bull World Health Organ. 2007; 85(4):324. doi:10.2471/BLT.07.032763 https://doi.org/10.2471/BLT.07.032763
World Health Organization. SARS outbreak contained worldwide. [Internet]. Geneva. WHO. [Updated on 2003 July 5; cited on 10.05.2021]. Available from: https://www.who.int/mediacentre/news/releases/2003/pr56/en/.
Wolfe, N., Dunavan, C. & Diamond, J. Origins of major human infectious diseases. Nature 2007; 447:279-283. https://doi.org/10.1038/nature05775
Mehmood I, Ijaz M, Ahmad S, Ahmed T, Bari A, Abro A, Allemailem KS, Almatroudi A, Tahir Ul Qamar M. SARS-CoV-2: An Update on Genomics, Risk Assessment, Potential Therapeutics and Vaccine Development. Int J Environ Res Public Health. 2021 Feb 8; 18(4):1626. doi: 10.3390/ijerph18041626. PMID: 33567746; PMCID: PMC7915969. https://doi.org/10.3390/ijerph18041626
Joshi S, Parkar J, Ansari A, Vora A, Talwar D, Tiwaskar M, Patil S, Barkate H. Role of favipiravir in the treatment of COVID-19. Int J Infect Dis. 2021 Jan; 102:501-508. doi: 10.1016/j.ijid.2020.10.069. Epub 2020 Oct 30. PMID: 33130203; PMCID: PMC7831863. https://doi.org/10.1016/j.ijid.2020.10.069
Wang Y, Zhang D, Du G, Du R, Zhao J, Jin Y, et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet. 2020 May 16;395(10236):1569-1578. doi: 10.1016/S0140-6736(20)31022-9. Epub 2020 Apr 29. Erratum in: Lancet. 2020 May 30; 395(10238):1694. PMID: 32423584; PMCID: PMC7190303.
Piscoya A, Ng-Sueng LF, Parra Del Riego A, Cerna-Viacava R, Pasupuleti V, Roman YM, Thota P, White CM, Hernandez AV. Efficacy and harms of remdesivir for the treatment of COVID-19: A systematic review and meta-analysis. PLoS One. 2020 Dec 10;15(12):e0243705. doi: 10.1371/journal.pone.0243705. PMID: 33301514; PMCID: PMC7728272. https://doi.org/10.1371/journal.pone.0243705
McCreary EK, Angus DC. Efficacy of Remdesivir in COVID-19. JAMA. 2020; 324(11):1041-1042. doi:10.1001/jama.2020.16337 https://doi.org/10.1001/jama.2020.16337
Arabi YM, Mandourah Y, Al-Hameed F, Sindi AA, Almekhlafi GA, Hussein MA, et al. Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome. Am J Respir Crit Care Med. 2018 Mar 15; 197(6):757-767. doi: 10.1164/rccm.201706-1172OC. PMID: 29161116. https://doi.org/10.1164/rccm.201706-1172OC
Lee N, Allen Chan KC, Hui DS, Ng EK, Wu A, Chiu RW, Wong VW, Chan PK, Wong KT, Wong E, Cockram CS, Tam JS, Sung JJ, Lo YM. Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients. J Clin Virol. 2004 Dec; 31(4):304-9. doi: 10.1016/j.jcv.2004.07.006. PMID: 15494274; PMCID: PMC7108318. https://doi.org/10.1016/j.jcv.2004.07.006
Mehta S, Pandey A. Rhino-Orbital Mucormycosis Associated With COVID-19. Cureus. 2020 Sep 30;12(9):e10726. doi: 10.7759/cureus.10726. PMID: 33145132; PMCID: PMC7599039. https://doi.org/10.7759/cureus.10726
Sharma S, Grover M, Bhargava S, Samdani S, Kataria T. Post coronavirus disease mucormycosis: a deadly addition to the pandemic spectrum [published online ahead of print, 2021 Apr 8]. J Laryngol Otol. 2021; 1-6. doi:10.1017/S0022215121000992 https://doi.org/10.1017/S0022215121000992
Denworth L. How the COVID-19 Pandemic Could End. What Comes Next. 2020; 322(6):44-45. Available from: https://www.scientificamerican.com/article/how-the-covid-19-pandemic-could-end1/.
Reuters Staff. WHO Reviewing Seychelles COVID-19 Data After Fully Vaccinated People Test Positive. Reuters. [Nairobi]. May 12, 2021. Available from: https://www.medscape.com/viewarticle/950898.
Ni L, Chen L, Huang X, et al. Combating COVID-19 with integrated traditional Chinese and Western medicine in China. Acta Pharm Sin B. 2020; 10(7):1149-1162. doi:10.1016/j.apsb.2020.06.009 https://doi.org/10.1016/j.apsb.2020.06.009
Denaro M, Smeriglio A, Barreca D, De Francesco C, Occhiuto C, Milano G, Trombetta D. Antiviral activity of plants and their isolated bioactive compounds: An update. Phytother Res. 2020 Apr;34(4):742-768. doi: 10.1002/ptr.6575. Epub 2019 Dec 19. PMID: 31858645. https://doi.org/10.1002/ptr.6575
Oyero OG, Toyama M, Mitsuhiro N, Onifade AA, Hidaka A, Okamoto M, Baba M. SELECTIVE INHIBITION OF HEPATITIS C VIRUS REPLICATION BY ALPHA-ZAM, A NIGELLA SATIVA SEED FORMULATION. Afr J Tradit Complement Altern Med. 2016 Sep 29; 13(6):144-148. doi: 10.21010/ajtcam.v13i6.20. PMID: 28480371; PMCID: PMC5412185. https://doi.org/10.21010/ajtcam.v13i6.20
Cui H.-T., Li Y.-T., Guo L.-Y., Liu X.-G., Wang L.-S., et al. Traditional Chinese medicine for treatment of coronavirus disease 2019: a review. Tradit. Med. Res. 2020; 5(2):65-73.
Lee DYW, Li QY, Liu J, Efferth T. Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis. Phytomedicine. 2021 Jan; 80:153337. doi: 10.1016/j.phymed.2020.153337. Epub 2020 Sep 28. PMID: 33221457; PMCID: PMC7521884. https://doi.org/10.1016/j.phymed.2020.153337
Wang Z, Yang L. Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts. J Ethnopharmacol. 2021 Apr 24; 270:113869. doi: 10.1016/j.jep.2021.113869. Epub 2021 Jan 21. PMID: 33485973; PMCID: PMC7825841. https://doi.org/10.1016/j.jep.2021.113869
Tong X, Li A, Zhang Z, Duan J, Chen X, Hua C, Zhao D, Xu Y, Shi X, Li P, Tian X, Lin F, Cao Y, Jin L, Chang M, Wang Y. TCM treatment of infectious atypical pneumonia--a report of 16 cases. J Tradit Chin Med. 2004 Dec; 24(4):266-9. PMID: 15688692.
Capodice, J.L., Chubak, B.M. Traditional Chinese herbal medicine-potential therapeutic application for the treatment of COVID-19. Chin Med 16, 24 (2021). https://doi.org/10.1186/s13020-020-00419-6 https://doi.org/10.1186/s13020-020-00419-6
Ling CQ. Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2). J Integr Med. 2020; 18(2):87-8. doi: 10.1016/j.joim.2020.02.004. [PubMed: 32122812]. [PubMed Central: PMC7129043]. https://doi.org/10.1016/j.joim.2020.02.004
Yang Y, Islam MS, Wang J, Li Y, Chen X. Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and Perspective. Int J Biol Sci. 2020; 16(10):1708- 17. doi: 10.7150/ijbs.45538. [PubMed: 32226288]. [PubMed Central: PMC7098036]. https://doi.org/10.7150/ijbs.45538
Luo E, Zhang D, Luo H, Liu B, Zhao K, Zhao Y, et al. Treatment efficacy analysis of traditional Chinese medicine for novel coronavirus pneumonia (COVID-19): an empirical study from Wuhan, Hubei Province, China. Chin Med. 2020; 15:34. doi: 10.1186/s13020-020-00317- x. [PubMed: 32308732]. [PubMed Central: PMC7156896]. https://doi.org/10.1186/s13020-020-00317-x
COVID-19 Pandemic: The Role of Traditional Medicine Faisal Muhammad 1, Int J Infect. 2020 July; 7(3):e107090 https://doi.org/10.5812/iji.107090
Zumla A., Chan J.F., Azhar E.I., Hui D.S., Yuen K.-Y. Coronaviruses-drug discovery and therapeutic options. Nat. Rev. Drug Discov. 2016; 15(5):327. https://doi.org/10.1038/nrd.2015.37
Zhao Z, Li Y, Zhou L, et al. Prevention and treatment of COVID-19 using Traditional Chinese Medicine: A review. Phytomedicine. 2021; 85:153308. doi:10.1016/j.phymed.2020.153308 https://doi.org/10.1016/j.phymed.2020.153308
An X, Zhang Y, Duan L, Jin D, Zhao S, Zhou R, Duan Y, Lian F, Tong X. The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-19. Biomed Pharmacother. 2021 May; 137:111267. doi: 10.1016/j.biopha.2021.111267. Epub 2021 Jan 14. PMID: 33508618; PMCID: PMC7836975. https://doi.org/10.1016/j.biopha.2021.111267
Wu XV, Dong Y, Chi Y, Yu M, Wang W. Traditional Chinese Medicine as a complementary therapy in combat with COVID-19-A review of evidence-based research and clinical practice. J Adv Nurs. 2021 Apr; 77(4):1635-1644. doi: 10.1111/jan.14673. Epub 2020 Nov 29. PMID: 33174654. https://doi.org/10.1111/jan.14673
Vellingiri B, Jayaramayya K, Iyer M, et al. COVID-19: A promising cure for the global panic. Sci Total Environ. 2020; 725:138277. doi:10.1016/j.scitotenv.2020.138277 https://doi.org/10.1016/j.scitotenv.2020.138277
Balachandar V., Mahalaxmi I., Kaavya J., Vivekanandhan G., Ajithkumar S., Arul N, et al. COVID-19: emerging protective measures. Eur. Rev. Med. Pharmacol. Sci. 2020; 24(6):3422-3425.
Joshi J, Puthiyedath R. Outcomes of Ayurvedic care in a COVID-19 patient with hypoxia - A case report. Journal of Ayurveda and Integrative Medicine. 2020. https://doi.org/10.1016/j.jaim.2020.10.006
Jacobs J. Homeopathic prevention and management of epidemic diseases. Homeopathy 2018; 107:157 60. https://doi.org/10.1055/s-0038-1649487
Shinde VH. Homoeopathy in pandemic Spanish flu 1918. Indian J Res Homoeopathy 2020; 14:152-9. https://doi.org/10.4103/ijrh.ijrh_32_20
Nayak, Debadatta. Homoeopathic Genus Epidemicus 'Bryonia alba' as a prophylactic during an outbreak of Chikungunya in India: A cluster -randomised, double -blind, placebo- controlled trial. Indian Journal of Research in Homoeopathy. 2014; 8:160-165. 10.4103/0974-7168.141739. https://doi.org/10.4103/0974-7168.141739
de Souza Nunes LA. Contribution of homeopathy to the control of an outbreak of dengue in Macaé, Rio de Janeiro. Int J High Dilution Res 2008; 7:186-92.
Bawaskar RS, Shinde VH. A Review of homoeopathic research in the prevention and treatment of dengue fever. Homoeopathic Links 2019;32:10-7. https://doi.org/10.1055/s-0039-1687897
Mathie RT, Baitson ES, Frye J, Nayak C, Manchanda RK, Fisher P. Homeopathic treatment of patients with influenza like illness during the 2009 A/H1N1 influenza pandemic in India. Homeopathy 2013; 102:187-92. https://doi.org/10.1016/j.homp.2013.04.001
Vincent S, Demonceaux A, Deswarte D, Scimeca D, Bordet MF. Management of influenza like illness by homeopathic and allopathic general practitioners in France during the 2009-2010 influenza season. J Altern Complement Med 2013; 19:146-52. https://doi.org/10.1089/acm.2011.0706
Clapers M, Velat M, Clapers J, Vidal-Jové J, Mora J. Analysis of Homeopathic Genus Epidemicus for COVID-19 Patients in Spain. Homeopathy. Publication Date:
May 2021 (online)
Varanasi R, Nayak D, Khurana A. Clinical Repurposing of Medicines is Intrinsic to Homeopathy: Research Initiatives on COVID-19 in India. Homeopathy. 2021 Apr 14. doi: 10.1055/s-0041-1725988. Epub ahead of print. PMID: 33853178. https://doi.org/10.1055/s-0041-1725988
Parvez M.K, Parveen S. Review Evolution and Emergence of Pathogenic Viruses: Past, Present, and Future Intervirology 2017; 60:1-7 https://doi.org/10.1159/000478729
Woolhouse M, Scott F, Hudson Z, Howey R, Chase-Topping M. Human viruses: discovery and emergence Philos Trans R Soc Lond B Biol Sci. 2012 Oct 19; 367(1604): 2864-2871. https://doi.org/10.1098/rstb.2011.0354
Ganguly S, Bakhshi S. Traditional and complementary medicine during COVID 19 pandemic Phytother Res. 2020 Aug 12; 10.1002/ptr.6828. https://doi.org/10.1002/ptr.6828
Seifert G, Jeitler M, Stange R, Michalsen A, Cramer H, Brinkhaus B, et al. The Relevance of Complementary and Integrative Medicine in the COVID-19 Pandemic: A Qualitative Review of the Literature. Front Med (Lausanne). 2020 Dec 11; 7:587749. doi: 10.3389/fmed.2020.587749. PMID: 33363186; PMCID: PMC7761649. https://doi.org/10.3389/fmed.2020.587749
Nugraha RV, Ridwansyah H, Ghozali M, Khairani AF, Atik N. Traditional Herbal Medicine Candidates as Complementary Treatments for COVID-19: A Review of Their Mechanisms, Pros and Cons. Evid Based Complement Alternat Med. 2020 Oct 10; 2020:2560645. doi: 10.1155/2020/2560645. PMID: 33101440; PMCID: PMC7569437. https://doi.org/10.1155/2020/2560645
Zhang MM, Liu XM, He L. Effect of integrated traditional Chinese and Western medicine on SARS: a review of clinical evidence. World J Gastroenterol. 2004; 10(23):3500-3505. doi:10.3748/wjg.v10.i23.3500 https://doi.org/10.3748/wjg.v10.i23.3500
Jeremy Y. Ng. Global research trends at the intersection of coronavirus disease 2019 (COVID-19) and traditional, integrative, and complementary and alternative medicine: a bibliometric analysis. BMC Complement Med Ther 2020; 20:353. https://doi.org/10.1186/s12906-020-03151-8 https://doi.org/10.1186/s12906-020-03151-8
Mirzaie A, Halaji M, Dehkordi FS, Ranjbar R, Noorbazargan H. A narrative literature review on traditional medicine options for treatment of corona virus disease 2019 (COVID-19). Complement Ther Clin Pract. 2020 Aug; 40:101214. doi: 10.1016/j.ctcp.2020.101214. Epub 2020 Jun 17. PMID: 32891290; PMCID: PMC7831809. https://doi.org/10.1016/j.ctcp.2020.101214
Srikanth N, Rana R, Singhal R, Jameela S, Singh R, Khanduri S, et al. Mobile App-Reported Use of Traditional Medicine for Maintenance of Health in India During the COVID-19 Pandemic: Cross-sectional Questionnaire Study. JMIRx Med. 2021 May 7; 2(2):e25703. doi: 10.2196/25703. PMID: 34032815; PMCID: PMC8110045. https://doi.org/10.2196/25703
World Health Organization. WHO supports scientifically-proven traditional medicine. 2020, [cited May 28, 2020]. Available from: https://www.afro.who.int/news/who-supports-scientificallyproven-traditional-medicine.
King DA, Peckham C, Waage JK, Brownlie J, Woolhouse ME Epidemiology. Infectious diseases: preparing for the future. Science. 2006 Sep 8; 313(5792):1392-3. https://doi.org/10.1126/science.1129134
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