Niosomes as Nano-carrier Based Targeted Drug Delivery System

Authors

  • Chanchal Joy Dept. of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy
  • Smitha K. Nair Dept. of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy
  • K Krishna Kumar Dept. of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy
  • B Dineshkumar Dept. of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy

Abstract

Niosomes are considered as novel nano-carrier in the drug delivery systems. These are much more stable than other nano-carriers like liposomes and nanoparticles. It is an example for targeted and control release of medication. The drug is entrapped into lipid core so that it prevents the drug from leaching. Here the drug will be targeted only to the desired cell/tissue and not to the non-targeted cells. By giving this formulation we can thereby reduce the dose of the drug and toxicity. This review article mainly emphasizes on the potential applications of niosomes in targeted drug delivery system.

Keywords: niosomes, nanocarriers, targeted drug delivery.

Keywords:

niosomes, nanocarriers, targeted drug delivery

DOI

https://doi.org/10.22270/jddt.v11i4-S.4907

Author Biographies

Chanchal Joy, Dept. of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy

Dept. of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala

St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy

Smitha K. Nair, Dept. of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy

Dept. of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala

St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy

K Krishna Kumar, Dept. of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy

Dept. of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala

St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy

B Dineshkumar, Dept. of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy

Dept. of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala

St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy

References

Madhav NVS, Saini A. niosomes: a novel drug delivery system, International Journal of research in pharmacy and chemistry, 2011; 1(3):498-511.

Sharma D, Ali AAE, Jayshree R. Aate, Niosomes as novel drug delivery systems: Review article. PharmaTutor, 2018; 6(3):58-65. https://doi.org/10.29161/PT.v6.i3.2018.58

Seleci DA, Seleci M, Walter JG, Niosomes as nanoparticular drug carriers: fundamentals and recent application. Hindawi Publishing Corporation Journal of Nanomaterials, 2016; Article ID 7372306, 13 pages. https://doi.org/10.1155/2016/7372306

Durga Bhavani G, Veera Lakshmi P, Recent advances of non-ionic surfactants-based nano-vesicles (niosomes and proniosomes): a brief review of these in enhancing transdermal delivery of drug, Future Journal of Pharmaceutical Sciences, 2020; 6:1-18. https://doi.org/10.1186/s43094-020-00117-y

Yadhav JD, Kulkarni PR, Vaidhya KA, Niosomes a review. Journal of Pharmacy Research, 2011; 4(3):632-636.

Mujoriya R, Bodla RB, Dhamande K, Singh D, Patle L, Niosomal Drug Delivery System: The Magic Bullet, Journal of Applied Pharmaceutical Science, 2011; 01(09):20-23.

Mohamad Saimi N.I, Salim N, Ahmad N, Abdulmalek E, Abdul Rahman, M.B, Aerosolized Niosome Formulation Containing Gemcitabine and Cisplatin for Lung Cancer Treatment: Optimization, Characterization and In Vitro Evaluation. Pharmaceutics, 2021; 13:59. https://doi.org/10.3390/pharmaceutics13010059

Rani N, Rana R, Thakur R, Single S, Formulation and evaluation of atorvastatin calcium niosomes, international journal of science and research archive, 2021; 02(01):116-124. https://doi.org/10.30574/ijsra.2021.2.1.0028

Ali F, Jafar A, Majid S, Maryam G, Neda A, Ali N, Methylene blue-loaded noisome: preparation, physicochemical characterization, and in vivo wound healing assessment, Drug Delivery and Translational Research, 2020; 10:1428-1441. https://doi.org/10.1007/s13346-020-00715-6

Jankie S, Johnson J, Adebayo AS, Pillai GK, Pereir LMP, Efficacy of Levofloxacin Loaded Nonionic Surfactant Vesicles (Niosomes) in a Model of Pseudomonas aeruginosa Infected Sprague Dawley Rats, Advances in Pharmacological and Pharmaceutical Sciences, V 2020; Article ID 8815969, 7. https://doi.org/10.1155/2020/8815969

Hajizadeh MR, Maleki H, Fahmidehkar MBMA. In vitro cytotoxicity assay of D-limonene niosomes: an efficient nano-carrier for enhancing solubility of plant-extracted agents, Research in Pharmaceutical Sciences, 2019; 14(5):448-45. https://doi.org/10.4103/1735-5362.268206

Sayeda Salma. S.A, Asha A N, V Kusum Devi, Formulation and evaluation of niosomes of mirtazapine for nasal delivery, Indo American Journal of Pharmaceutical Research, 2019; 9(05):2011-2037.

Lu B, Huang Y, Chen Z, Ye J, Xu H, Chen W, Long X, Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant Molecules, 2019; 24:2322. https://doi.org/10.3390/molecules24122322

Anindita De, Nagasamy Venkatesh, M Senthil, Bharat Kumar Reddy Sanapalli, R Shanmugham, and Veera Venkata Satyanarayana Reddy Karri, Smart niosomes of temozolomide for enhancement of brain targeting, Nano biomedicine, 2018; 5:1-11. https://doi.org/10.1177/1849543518805355

Pankaj, Satish Chander Arora and Rashmi Manchanda, Formulation, Evaluation and Optimization of Glipizide loaded Niosomes, International Journal of Chemtech Research, 2018; 11(09):08-14. https://doi.org/10.20902/IJCTR.2018.110902

Barani M, Mirzael M, Mahani T, Evaluation of carum loaded Nisomes on breast cancer cells: Physicochemical properties, in vitro cytotoxicity, flow cytometric, DNA Fragmentation and cell migration Assay, Scientific Reports, 2019; 9:7139. https://doi.org/10.1038/s41598-019-43755-w

Shaikh K, Pandhe P, Kale S, Bothiraja C, Development and Evaluation of a Novel Drug Delivery System for Albendazole, Indian Journal of Pharmaceutical Education and Research, 2018; 52(3):408-415. https://doi.org/10.5530/ijper.52.3.47

Leila Kanaani, Iraj javadi, Meysam Ebrahimifar, Hasan Ebrahimi shahmabadi, Azim Akbarzadeh Khiyavi, Torkan Mehrdib, Effects of Cisplatin-Loaded Niosomal Nanoparticles on BT-20 Human Breast Carcinoma Cells, Asian Pac J Cancer Prev, 2017; 18(2):365-368. https://doi.org/10.31557/apjcb.2017.2.2.27-29

Nagalakshmi. S, Kalaiaperumal K, Arul JM, Chaudhari PS, Pushpalatha HB, Shanmuganthan S, Fabrication and Characterization of Herbal Drug -Loaded Nonionic Surfactant Based Niosomal Topical Gel, J. Pharm. Sci. & Re, 2016; 8(11):1271-1278.

Ying Qi Xu, Wen Rong Chen, Jonathan K. Tsosie, Xi Xie, Niosome encapsulation of curcumin: characterization and cytotoxic effect on ovarian cancer cells, Journal nanomaterials, 2016; Article ID: 6365295. https://doi.org/10.1155/2016/6365295

Dwivedi A, Mazumder A, du Plessis L, du Preez JL, Haynes RK, du Plessis J, "In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells," Nanomedicine: Nanotechnology, Biology, and Medicine.2015; 11(8):2041-2050. https://doi.org/10.1016/j.nano.2015.07.010

Goyal G, Garg T, Malik B, Chauhan G, Rath G, Goyal AK, Development and characterization of niosomal gel for topical delivery of benzoyl peroxide, Drug Delivery, 2013; 22(8):1027-1042. https://doi.org/10.3109/10717544.2013.855277

Punitha valli, M. Vignesh, Formulation of niosomal suspension with enhanced oral bioavailability of diclofenac sodium, Journal of Global Trends in Pharmaceutical Sciences,2012; 2(3):656-671.

Kamboj S, Saini V, Bala S, Formulation and Characterization of Drug Loaded Nonionic Surfactant Vesicles (Niosomes) for Oral Bioavailability Enhancement, The Scientific World Journal, 2014, Article ID 959741. https://doi.org/10.1155/2014/959741

Wagh VD, Deshmukh OJ, Itraconazole Niosomes Drug Delivery System and Its Antimycotic Activity against Candida albicans, International Scholarly Research Network. 2012, Article ID 653465, 7 pages. https://doi.org/10.5402/2012/653465

Jankie S, Johnson J, Adebayo AS, Pillai GK, Pereira LMP, Efficacy of Levofloxacin Loaded Nonionic Surfactant Vesicles (Niosomes) in a Model of Pseudomonas aeruginosa Infected Sprague Dawley Rats, Advances in Pharmacological and Pharmaceutical Sciences, V 2020, Article ID 8815969, 7 pages. https://doi.org/10.1155/2020/8815969

Han W, Wang S, Liangetal R, Non-ionic surfactant vesicles simultaneously enhance antitumor activity and reduce the toxicity of cantharidin," International Journal of Nanomedicine, 2013; 8:2187-2196. https://doi.org/10.2147/IJN.S43568

Shaker D.S, Shaker M.A, Hanafy M.S, Cellular uptake, cytotoxicity and in-vivo evaluation of Tamoxifen citrate loaded niosomes. International Journal of Pharmaceutics, 2015; 493:285-294. https://doi.org/10.1016/j.ijpharm.2015.07.041

Tavano L, Muzzalupo R, Mauro L, Pellegrino M, Picci N, Transferrin-conjugated Pluronic niosomes as a new drug delivery system for anti-cancer therapy, Langmuir, 2013; 29(41):12638-12646. https://doi.org/10.1021/la4021383

Published

2021-08-15
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How to Cite

1.
Joy C, Nair SK, Krishna Kumar K, Dineshkumar B. Niosomes as Nano-carrier Based Targeted Drug Delivery System. J. Drug Delivery Ther. [Internet]. 2021 Aug. 15 [cited 2026 Jan. 13];11(4-S):166-70. Available from: https://www.jddtonline.info/index.php/jddt/article/view/4907

How to Cite

1.
Joy C, Nair SK, Krishna Kumar K, Dineshkumar B. Niosomes as Nano-carrier Based Targeted Drug Delivery System. J. Drug Delivery Ther. [Internet]. 2021 Aug. 15 [cited 2026 Jan. 13];11(4-S):166-70. Available from: https://www.jddtonline.info/index.php/jddt/article/view/4907

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