A Review on Central Pontine Myelinolysis and Correction of Hyponatremia in Hospitalized Patients
Abstract
Pontine myelinolysis (PM) can be a nerve disorder represented by pons demyelination. it is characterized by damage to regions of the brain, most commonly tracts pontine substantia alba, after rapid correction of metabolic disorders such as hyponatremia. PM (Pontine Myelinolysis) is categorized into Central pontine myelinolysis (CPM) and extra pontine myelinolysis (EPM). The various studies revealed that quick correction of hyponatremia plays a vital role in the pathogenesis of ODS. Prevention of ODS must be conducted by gradually increasing sodium concentration of 4–6 mmol/Lin in any 24-h period. PubMed and Medline literature search was done using CPM and hyponatremia as keywords. The principal aim of this review is to encapsulate, the recent evidence from literature about the association between rapid correction of hyponatremia and central pontine myelinolysis.
Keywords: Demyelination syndrome, EPM, CPM, Serum tonicity, Hyponatremia, Demyelination
Keywords:
Demyelination syndrome, EPM, CPM, Serum tonicity, Hyponatremia, DemyelinationDOI
https://doi.org/10.22270/jddt.v11i4.4876References
Norenberg MD, Leslie KO, Robertson AS, Association between rise in serum sodium and central pontine myelinolysis, Annals of Neurology Official Journal of the American Neurological Association and the Child Neurology Society, 1982; 11(2):128-35. https://doi.org/10.1002/ana.410110204
Laureno R, Central pontine myelinolysis following rapid correction of hyponatremia, Annals of Neurology, Official Journal of the American Neurological Association and the Child Neurology Society, 1983; 13(3):232-42. https://doi.org/10.1002/ana.410130303
Menger H, Jorg J, Outcome of central pontine and extrapontine myelinolysis (n= 44), Journal of neurology, 1999; 246(8):700-5. https://doi.org/10.1007/s004150050435
Singh T D, Fugate J E, Rabinstein AA, Central pontine and extrapontine myelinolysis a systematic review, European Journal of Neurology, 2014; 21(12):1443-50. DOI: https://doi.org/10.1111/ene.12571
Graff-Radford J, Fugate JE, Kaufmann TJ, Mandrekar JN, Rabinstein AA, Clinical and radiologic correlations of central pontine myelinolysis syndrome, In Mayo Clinic Proceedings 2011; 86(11):1063-1067 DOI: https://doi.org/10.4065/mcp.2011.0239
Alleman AM, Osmotic demyelination syndrome: central pontine myelinolysis and extrapontine myelinolysis. In Seminars in Ultrasound, CT and MRI 2014; 35(2):153-159 DOI: https://doi.org/10.1053/j.sult.2013.09.009
King JD, Rosner MH, Osmotic demyelination syndrome, Am J Med Sci, 2010 Jun; 339(6):5617. https://doi.org/10.1097/MAJ.0b013e3181d3cd78 .
Renjen PN, Chaudhari D, Namala V, Central pontine and extrapontine myelinolysis, Apollo Medicine, 2016; 13(4):220-223. https://doi.org/10.1016/j.apme.2016.11.001
Sterns RH, Silver S, Kleinschmidt De Masters BK, Rojiani AM, Current perspectives in the management of hyponatremia prevention of CPM, Expert review of neurotherapeutics, 2007; 7(12):1791-7. https://doi.org/10.1586/14737175.7.12.1791
Sterns RH, Hix JK, Silver S. Treating profound hyponatremia a strategy for controlled correction, American journal of kidney diseases, 2010; 56(4):774-9. https://doi.org/10.1053/j.ajkd.2010.04.020
Sterns RH, Hix JK, Overcorrection of hyponatremia is a medical emergency, Kidney international, 2009; 76(6):587-9. DOI: https://doi.org/10.1038/ki.2009.251
Kengne FG, Soupart A, Pochet R, Brion JP, Decaux G, Re-induction of hyponatremia after rapid overcorrection of hyponatremia reduces mortality in rats, Kidney international, 2009; 76(6):614-21. DOI: https://doi.org/10.1038/ki.2009.254
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