A review on ethnobotany, phytochemistry and pharmacology on Terminalia belerica (Bibhitaki)

  • Panshul Sharma School of Pharmacy, Abhilashi University, Mandi-175028, Himachal Pradesh, India
  • Kapil Kumar Verma School of Pharmacy, Abhilashi University, Mandi-175028, Himachal Pradesh, India
  • Hans Raj School of Pharmacy, Abhilashi University, Mandi-175028, Himachal Pradesh, India
  • Nutan Thakur School of Pharmacy, Abhilashi University, Mandi-175028, Himachal Pradesh, India

Abstract

Terminalia belerica Roxb. is belonging to family combretaceae, which is growing widely throughout the Indian  subcontinent,  Bangladesh,  Nepal,  Sri-Lanka, and  South East Asia. It is is used in several traditional medicines to cure various diseases. There are different phytoconstituents Glucoside, Tannins, ellagic acid, ethylgallate, gallylglucose, chebulanic acid which are responsible for its wide therapeutic actions. It is mainly used as antioxidant, antimicrobial, antidiarrhoeal, anticancer, antidiabetic, antihypertensive and hepatoprotective agent. This review article sites the information of different pharmacological activities of Terminalia belerica which may be source for further research studies.


Keywords: Phytoconstituents, pharmacologicalactivities, Terminaliabelerica, therapeutic actions.

Keywords: Phytoconstituents, pharmacologicalactivities, Terminalia belerica, therapeutic actions

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Author Biographies

Panshul Sharma, School of Pharmacy, Abhilashi University, Mandi-175028, Himachal Pradesh, India

School of Pharmacy, Abhilashi University, Mandi-175028, Himachal Pradesh, India

Kapil Kumar Verma, School of Pharmacy, Abhilashi University, Mandi-175028, Himachal Pradesh, India

School of Pharmacy, Abhilashi University, Mandi-175028, Himachal Pradesh, India

Hans Raj, School of Pharmacy, Abhilashi University, Mandi-175028, Himachal Pradesh, India

School of Pharmacy, Abhilashi University, Mandi-175028, Himachal Pradesh, India

Nutan Thakur, School of Pharmacy, Abhilashi University, Mandi-175028, Himachal Pradesh, India

School of Pharmacy, Abhilashi University, Mandi-175028, Himachal Pradesh, India

References

1. Farnsworth NR, Soejarto DD. Global importance of medicinal plants. The conservation of medicinal plants. 1991; 26:25-51
2. Gilani HA, Khana A, Tuba Ali T and Ajmal S. Mechanisms underlying the antispasmodic and bronchodilatory properties of Terminalia belerica fruit. J Ethnopharmacol. 2008;528
3. Chandran U, Patwardhan B. in Innovative Approaches in Drug Discovery. 2017.
4. Baliga MS, Haniadka R. Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults. 2015.
5. Saraphanchotiwitthaya A, Sripalakit P and Ingkaninan K. Effects of Terminalia belericaRoxb. Methanolic extract on mouse immune response in vitro. MaejoInternational Journal of Science and Technology. 2008; 400.
6. Mallik J, Das P, Karon B, Das S. A review on phytochemistry and pharmacological activity of Terminalia belerica. International journal of drug formulation and research. 2012; 3(6):1-5.
7. Mahboubi M, Shahcheraghi F, Feizabadi M M. Bactericidal effects of essential oils from clove, lavender and geranium on multi-drug resistant isolates of Pseudomonas aeruginosa. In Iranian Journal of Biotechnology. vol. 4. 2006; 137- 40.
8. Oke JM, Hamburger MO. Screening of some Nigerian medicinal plants for antioxidant activity using 2, 2, diphenyl-picryl-hydrazyl radical. Afr. J. Biomed. Res. 2002; 5:1-2.
9. Atal CK, Sharma ML, Kaul A, Khajuria A. Immunomodulating agents of plant origin. Preliminary screening. J Ethnopharmacology 1986; 41:185–192.
10. Hung JW and Chung WC. Management of vegetable crops disease with plant extracts. Adv Plant Dis Management. 2003; 37:153-163.
11. Kumudhavalli MV, Vyas M and Jayakar B, Phytochemical and pharmacological evaluation of the plant fruit of Terminalia bellirica Roxb, Int J Pharm Life Sci. 2010; 1(1): 1-11.
12. Pingale SS. Hepatoprotective action of Terminalia belerica on CCl4 induced hepatic disorders. Der Pharm Chemi. 2011; 3:42-48.
13. Alam B. Antioxidant, Antimicrobial and Toxicity studies of the Different Fractions of Fruits of Terminalia belericaRoxb. Global Journal of Pharmacology. 2011; 17.
14. Kumar B, Divakar K, Tiwari P, Salhan M, Goli D. Evalution of Anti- Diarrhoeal Effect of Aqueous And Ethanolic Extracts of Fruits Pulp of Terminalia belerica In Rats. International Journal of Drug Development and Research. 2010; 779.
15. Gilani AH, Khan AU, Ali T, Ajmal S. Anti-Spasmodic and Bronchodilatory Properties of Terminalia belerica Fruit.Journal of Ethnopharmacology.2008; 538
16. .Meena AK, Yadav A, Singh U, Singh B, Sandeep et al, Evaluation of physicochemical parameters on the fruit of Terminalia bellirica Roxb. Int J Pharmacy Pharm Sci. 2010;2:96-98.
17. Karthikeyan M, Kannan M, Rajasekar S and Saraswathi MN. Terminalia belerica Roxb. A Phytopharmacological Review. Int J Res Pharm Biomed Sci. 2012; 3:96-99.
18. Das P, Karon B, Das S,and Mallik J. A review on phytochemistry and pharmacological activity of Terminalia belerica. Int J Drug Form Res. 2012; 07.
19. Abraham A, Mathew L, and Samuel S. Pharmacognostic studies of the fruits of Terminaliabellirica (Gaertn.) Roxb. J Pharm Phytochem. 2014; 52.
20. Saroya AS. Herbalism phytochemistry and Ethnopharmacology. Science Publishers.2011; 361.
21. http://www.worldagroforestry.org/treedb/AFTPDFS/Ter minalia_bellirica.PDF,https://www.easyayurveda.com/2013/01/13/bibhitakibaheda-terminalia-bellerica-uses-ayurveda-details
22. Sharma A. Terminalia bellirica medicinal uses and pictures. (http://www.homeremediess.com/ terminalia-bellerica-medicinal-uses-and-pictures). 2015.
23. Nadkarni K M, Indian Meteria Medica (Popular Prakashan Pvt. Ltd. Mumbai). 2002; 1202-1205.
24. Singh A. Medicinal Plants of the World (Oxford and IBH Co. Pvt, New Delhi). 2006; 26.
25. Anand KK, Singh B, Saxena AK, Chandan BK, Gupta VN and Bhardwaj V. The Hepatoprotective principle in the fruits of Terminalia bellirica bioassay guided activity. Pharmacol Res. 1997; 36: 315-321.
26. Molla MTH, Alam MT and Islam MA. Physico-chemical and nutritional studies of Terminalia bellirica Roxb. seed oil and seed kernel. J Bio-Sci. 2007; 15: 117-126.
27. Nandy A K, Podder G, Sahu N P and Mahato S B. Triterpenoids and their glucosides from Terminalia bellerica. Phytochem. 1989;28: 2769-2772.
28. Row L R and Murty P S. Chemical examination of Terminalia bellirica Roxb. Indian J Chem.1970; 8: 1047-1048.
29. Valsaraj R, Pushpangadan P, Smitt U W and Adsersen A. New anti-HIV-1, antimalarial, and antifungal compounds from Terminalia bellerica. J Nat Prod. 1997; 60(7):739–742.
30. Khan A U, Hassan A and Gilani, Pharmacodynamic evaluation of Terminalia bellirica for its anti-hypertensive effect. J Food Drug Anal.2008; 16: 6-14
31. Bade JD, Ahera AN, Mandal SC, Belsare DP and Pal SC. Isolation and characterization of hydrolysable tannins from leaf of Terminalia bellirica Roxb. J Pharm Res. 2010; 3: 2410- 2414.
32. Ayoob FA, Awad HM, El-Kousy SM, Rashed KN and Al-Sayed N H. Phytochemical and biological investigations of Terminalia bellirica Roxb. leaves. J Pharm Res. 2014; 8(4) 500-510.
33. Shankar M, Teja TL, Ramesh BD, Kumar R, Ramanarao D N V, et al. Phytochemical investigation and antibacterial activity of hydroalcoholic extract of Terminalia bellirica leaf. Asian J Phytomed Clin Res. 2014; 2(1):33 - 39.
34. Refahy L A and Saad M A. Characterization of chemical constituents,reducing power and anticancer activities of Terminalia bellirica Roxb. Acad J Cancer Res. 2014;7(2): 117-125.
35. Vaidyaratnam PS. Indian Medicinal Plants. Published by Orient Longman Private Ltd. Chennai.2004; 5: 258-262
36. Roy S K, Pal P K and Das A K . Propagation of a timber tree Terminalia bellirica Roxb. by tissue culture. Bangladesh J Bot. 1987; 16:125–130.
37. Rastogi RP and Mehrotra BN. Compendium of medicinal plants central drug research institute (CDRI), Lucknow and National institute of communication and information resources. New Delhi. 2004; 406.
38. Kirtikar KR and Basu BD. Indian medicinal plants. 2nd edn (International Book Distributors, Dehradun).1999.
39. Ghani A. Medicinal plants of Bangladesh with chemical constituents and uses. Asiatic Society of Bangladesh. Dhaka Ramna. 2003;184.
40. Aneja KR, Sharma C and Joshi R. Antimicrobial activity of Terminalia arjuna Wight & Arn an ethnomedicinal plant against pathogens causing ear infection. Braz J Otorhinolaryngol. 2012; 74.
41. Devi PN, Kaleeshwari S and Poonkothai M. Antimicrobial activity and phytochemical analysis of fruit extract of Terminalia belerica. Int J Pharm Pharma Sci. 2014; 642.
42. Fahmy NM, Al-Sayed E and Singab AN. Genus Terminalia A phytochemicals and biological Review. Med Aroma Plants. 2015; 21.
43. Saroya SA. Herbalism phytochemistry and ethnopharmacology (Science Publishers).2011; 357-361.
44. Guleria S, Tiku AK and RanaS. Antioxidant activity of acetone extract/ fractions of Terminalia bellericaRoxb. Fruit. Ind J BiochemBiophys. 2010; 110.
45. Hanahan D, and Weinberg RA,The hallmarks of cancer. Cell. 2000; 57.
46. Kadian R, Parle M, Yadav M. Therapeutic potential and phytopharmacology of Terminalia bellerica. WJPPS. 2014; 3(10):804-19
47. SaxenaV, MishraG, Saxena A and Vishwakarma K.K . A comparative study on quantitative estimation of tannins in Terminalia Chebula, Terminalia Belerica, Terminalia Arjuna and Saraca indica using spectrophotometer. Asian J Pharm Clin Res. 2013; 6:148-149.
48. Sharangouda J , Satishgouda S, Vishwanatha T and Saraswati B. Effect of Terminalia belerica barks extracts on activties of accessory productive ducts in male rats. International Journal of Pharmaceutical science Review and Research. 2014; 75.
49. Thanabhorn S, Jaijoy K, Thamaree S, Ingkaninam K. Acute and Sub-acute Toxicities of the Ethanol Extract of fruit of Terminaliabelerica. Journal of Pharmacuetical sciences.2009. The Ayurvedic Pharmacopoeia of India. 1st edition published by the controller of Publications. Civil Lines, New Delhi. 2001; 1(01):252.
50. Saraphanchotiwitthaya A, and Ingkaninan K . Immunomodulatory activity of an acetone extract of Terminaliabelericaroxb fruit on the mouse immune response in vitro. Int J Pharm Pharma Sci. 2014; 274.
51. Shaikh S, Lochan R, Kaul P, Tandon GD. Beta lactamase Inhibitors from Indigenous Herbs and Spices. Res. J. of Pharmaceutical. Biological and Chemical Sci. 2001; 275.
52. Yadav S, Singh S, Sharma P, Thapliyal A, Gupta, Antibiofilm Formation Activity of Terminaliabellerica Plant Extract Against Clinical Isolates of Streptococcus mutans and Streptococcus sobrinus. Implication in Oral Hygiene. Int. J of Pharmaceu. & Bio Arch. 2012; 816.
53. .Choudhary GP. Anti-ulcer activity of the ethanolic extract of Terminalia belericaRoxb. Int. J. of Pharmaceutical and Chemical Sci. 2012; 97.
54. Gangadhar M, Patil B, Yadav S, and SindeD. Isolation and characterization of gallic acid from Terminalia belerica and its effect on carbohydrate regulatory system in vitro. Int J Res Ayur Pharm. 2011; 562.
55. Saha PK, Patrab PH, Pradhan R, RadharamanDey, Shyamal Das, Mandal TKV. Effect of Terminaliabelerica&Terminaliachebula on wound healing in induced dermal wounds in Rabbits. Pharmacology online. 2011; 235.
56. Khan AU, Gilani AH. Pharmacodynamic Evaluation of Terminalia belerica for its Anti-Hypertensive Effect. Journal of Food and Drug Analysis. 2008; 14.
57. Latha PCR, and Daisy P. Influence of Terminalia belerica Roxb. Fruits Extract on Biochemical Parameters. In Streptozotocin Diabetic Rats. International Journal of Pharmacology.2010; 89.
58. Sharma SU, Sharma US, Singh A, Sutar N, Singh PJ. Screening of Terminaliabellirica Fruits Extracts for its Analgesic and Antipyretic Activities. Jordan J of Bio Sci. 2014; 121.
59. Sabu MC and Kuttan R. Anti diabetic and Anti oxidant activity of Terminaliabelerica Roxb. Indian Journal of Experimental Biology. 2009;270.
60. Madani A, Jain SK, Anti-Salmonella Activity of Terminaliabelerica. In vitro and in vivo Studies. Indian Journal of Experimental Biology. 2008; 817.
61. Shukla S, Jadon A and Bhadauria M. Protective effect of Terminaliabelerica Roxb and gallic acid against carbon tetra chloride induced damage in albino rats. Journal of Ethnopharmacology.2008; 214
62. Abdel M, Sherif RZ and Bloomston M. Liver Anatomy. Surg Clin North America. 2010; 90:643-653.
63. Rajesh MG and Latha MS .Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage. Ind J Pharm.2004; 36:284-287.
64. Hazra B, Sarkar R. and Mandal N. Protection of Terminalia bellerica Roxb. against iron overload induced liver toxicity. An account of its reducing and iron chelating capacity. Am J Pharm Toxicol.2012; 7:109-122.
65. Elizabeth KM. Antimicrobial activity of Terminalia bellerica. Ind J ClinBiochem. 2005; 153.
66. Kaur S, Arora S, Kaur S, Kumar S. Bioassay-guided isolation of anti-mutagenic factors from fruits of Terminalia bellerica. J Environ PatholToxicol Oncol. 2003; 69.
67. Upadhyay N, Tiwari S K, Srivastava A, Seth A, and Maurya S K . Anti-urolithiatic effect of Terminalia bellirica Roxb. fruits on ethylene glycol-induced renal calculi in rats. Indo Am J Pharm Res. 2015; 5(5): 203.
68. .Fatima N and Sultana H. Evaluation of protective effect of Terminalia bellirica against gentamicin induced nephrotoxicity in albino rats. Pharmaceut Biol Evaluat. 2016; 3(5)486:494
69. Prabhu VV, Chidambaranathan N and Gopa V. Evaluation and quantification of angiogenesis activity of Terminalia Bellirica Roxb. by mice sponge implantation method. J Young Pharm. 2012; 4(1):22–27.
70. Prasad S, Kashyap RS, Deopujari JY, Purohit HJ, Taori GM et al. Effect of Fagoniaarabica (Dhamasa) on in vitro thrombolysis. BMC Complement Altern Med. 2007; 7: 36.
71. Ansari AV, Siddiqui HH and Singh PS. Antithrombotic and thrombolytic activity of Terminalia belerica fruit extracts. Res J Pharm BiolChemSci. 2012; 78.
72. Varshney S, Varshney P, Dash SK, Gupta KM, Kumar A, Bist B and Sharma A. Medicinal Plants. 2012; 4(3) : 167-169
73. Gupta R, Singh RL, Gupta A. Antioxidant, DNA protective and antibacterial activities of Terminalia bellerica extracts. Vol.13.2019; 431-442.
74. Chauhan P, Singh S, Gupta YK, Kumar U.Downloaded free from http://www.jnsbm.org on, 2020;IP: 106.205.168.124.
75. Chavan LV, Anita P, Naresh C. Antioxidant Availabiltiy of Beheda (Terminalia bellerica (Roxb.) in Relation to its Medicinal Uses. 2010.
76. Young IS and Woodside JV. Antioxidant in health and diseases. J Clin Path. 2004; 54: 176-186.
77. Vani T, Rajani M, Sarkar S & Shishoo CJ. Antioxidant properties of the ayurvedic formulation triphala and its constituents. International Journal of Pharmacognosy. 1997; 35(5):313-317
78. Pfundstein B, Desouky El, Hull SK, Haubner WE, Erben RG & Owen RW . Polyphenolic compounds in the fruits of Egyptian medicinal plants (Terminalia bellerica, Terminalia chebula and Terminalia horrida) characterization, quantitation and determination of antioxidant capacities. Phytochemistry. 2010; 71(10):1132-1148.
79. Das CMS and Devi SG. Journal of Chemical and Pharmaceutical Research. 2016; 8(3):191-197
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Sharma P, Verma K, Raj H, Thakur N. A review on ethnobotany, phytochemistry and pharmacology on Terminalia belerica (Bibhitaki). JDDT [Internet]. 15Feb.2021 [cited 9May2021];11(1-s):173-81. Available from: https://www.jddtonline.info/index.php/jddt/article/view/4739