A Review on Herbal Plants used in Brain Ischemic and Reperfusion Injury

Authors

  • Simran Singh Department of Pharmacology, School of Pharmaceutical Science, IFTM University, Moradabad, India
  • Shayan Shafi Department of Pharmacology, School of Pharmaceutical Science, IFTM University, Moradabad, India
  • Alankar Shrivastav Department of Pharmacology, Pharmacy Academy, IFTM University, Moradabad, India
  • Shahbaz Khan Department of Pharmacology, Pharmacy Academy, IFTM University, Moradabad, India
  • Tanzeel Ahmad School of Biotechnology, IFTM University, Moradabad, India
  • Najam Ali Khan Department of Pharmacology, School of Pharmaceutical Science, IFTM University, Moradabad, India

Abstract

A stroke causes serious and long term brain disability due to disruption in the blood flow to the brain. Clinically major changes occur in brain functions are seen after brain ischemia and reperfusion. Patients show emotional, behavioural, and cognitive alterations during retrieval time. Cerebral injury by transient ischemia distresses the number of patients globally with death or long term disability. In recent years a great deal of research has been carried out to find the effectiveness of the herbal drug for the treatment of stroke. Both thrombolytic and neuro-protective activities of herbal drugs may be a new strategy for effective stroke treatment. This article reviews the list of universally used plants effective for brain stroke therapies. The purpose of this article was to collect the herbal drugs useful in brain stroke therapies.

Keywords: ischemia-reperfusion, brain injury, stroke, herbal drugs, tissue

Keywords:

ischemia-reperfusion, brain injury, stroke, herbal drugs, tissue

DOI

https://doi.org/10.22270/jddt.v10i5.4415

Author Biographies

Simran Singh, Department of Pharmacology, School of Pharmaceutical Science, IFTM University, Moradabad, India

Department of Pharmacology, School of Pharmaceutical Science, IFTM University, Moradabad, India

Shayan Shafi, Department of Pharmacology, School of Pharmaceutical Science, IFTM University, Moradabad, India

Department of Pharmacology, School of Pharmaceutical Science, IFTM University, Moradabad, India

Alankar Shrivastav, Department of Pharmacology, Pharmacy Academy, IFTM University, Moradabad, India

Department of Pharmacology, Pharmacy Academy, IFTM University, Moradabad, India

Shahbaz Khan, Department of Pharmacology, Pharmacy Academy, IFTM University, Moradabad, India

Department of Pharmacology, Pharmacy Academy, IFTM University, Moradabad, India

Tanzeel Ahmad, School of Biotechnology, IFTM University, Moradabad, India

School of Biotechnology, IFTM University, Moradabad, India

Najam Ali Khan, Department of Pharmacology, School of Pharmaceutical Science, IFTM University, Moradabad, India

Department of Pharmacology, School of Pharmaceutical Science, IFTM University, Moradabad, India

References

Krause GS, Kumar K, White BC, Aust SD, Wiegenstein JG. Ischemia, resuscitation, and reperfusion: mechanisms of tissue injury and prospects for protection. Am Heart J 1986; 111(4):768-80.

White BC, Sullivan JM, DeGracia DJ, O'Neil BJ, Neumar RW, Grossman LI, et al. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci 2000; 179(S 1–2):1-33.

Lo EH, Dalkara T, Moskowitz MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 2003; 4(5):399-415.

Donnan GA, Davis SM, Parsons MW, Ma H, Dewey HM, Howells DW. How to make better use of thrombolytic therapy in acute ischemic stroke. Nat Rev Neurosci 2011; 7(7):400-9.

Formigli, L. et al. Human Path. 1992; 23:627

Silver, M.J. et al. Circulation 1995; 92:492.

Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001; 21(1):2-14.

Joo F, Klatzo I. Role of cerebral endothelium in brain oedema. Neurol Res 1989; 11(2):67-75.

Betz AL, Iannotti F, Hoff J. Brain edema: a classification based on blood-brain barrier integrity. Cerebrovasc Brain Metab Rev 1988; 1(2):133-54.

Ayata C, Ropper AH. Ischaemic brain oedema. J Clin Neurosci 2002; 9(2):113-24.

Hossmann KA, Schuier FJ. Experimental brain infarcts in cats. I. Pathophysiological observations. Stroke 1980; 11(6):583-92.

Vannucci RC, Yager JY, Vannucci SJ. Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat. J Cereb Blood Flow Metab 1994; 14(2):279-88.

Love S. Oxidative stress in brain ischemia. Brain Pathol 1999; 9(1):119-31.

Wyatt JS, Edwards AD, Azzopardi D, Reynolds EO. Magnetic resonance and near infrared spectroscopy for investigation of perinatal hypoxic-ischaemic brain injury. Arch Dis Child 1989; 64(7 Spec No):953-63.

Cunningham LA, Wetzel M, Rosenberg GA. Multiple roles for MMPs and TIMPs in cerebral ischemia. Glia 2005; 50(4):329-39.

Shalak L, Perlman JM. Hypoxic-ischemic brain injury in the term infant-current concepts. Early Hum Dev 2004; 80(2):125-41.

Gasche Y, Copin JC, Sugawara T, Fujimura M, Chan PH. Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia. J Cereb Blood Flow Metab 2001; 21(12):1393-400.

Jivad N, Rabiei Z. Review on herbal medicine on brain ischemia and reperfusion. Asian Pacific Journal of Tropical Biomedicine.2015; 10.1016/j.

Wang D, Wang Q, Chen R, Yang S, Li Z, FengY. Exploring the effects of Gastrodia elata Blume on the treatment of cerebral ischemia-reperfusion injury using UPLC-Q/TOF-MS-based plasma metabolomics. The Royal Society of Chemistry. 2019 10.1039/c9fo01729a.

Shamima M, Khana NI. Neuroprotective effect of Panax ginseng extract against cerebral ischemia– reperfusion-injury-induced oxidative stress in middle cerebral artery occlusion models. FACETS 2019 4:52–68 DOI: 10.1139/facets-2018-0025.

Akram Torki, Valiallah Khalaji-Pirbalouty, Zahra Lorigooini, Mahmoud Rafieian-Kopaei, Arezo Sadeghimanesh and Zahra Rabiei. Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion. Braz. J. Pharm. 2018 Sci. vol.54 no.1 São Paulo.

Deng Y, Lam FFY, Ng ESK, Lau CBS, Koon JCM, Leung PC and Fung KP. A Herbal Formulation of Danshen and Gegen Protects Rat Brains from Injuries Induced by Focal and Global Ischaemia. ScholArena 2018, 1:104.

Hamidreza Mahmoudzadeh-Sagheb, Zahra Heidari and Maryam Sarbishegi. Withania coagulans Protects Striatum from Oxidative Damages Induced by Global Brain Ischemia in Rat. Jundishapur J Nat Pharm Prod. 2018; 13(2):e65051.

Sarkaki A, Rafieirad M, Hossini SE, Farbood Y, Mansouri SMT, et al. Cognitive deficiency induced by cerebral hypoperfusion/ischemia improves by exercise and grape seed extract. Health Med 2012; 6(4):1097-1104.

Hobbenaghi R, Javanbakht J, Sadeghzadeh S, Kheradmand D, Abdi F, et al. Neuroprotective effects of Nigella sativa extract on cell death in hippocampal neurons following experimental global cerebral ischemia-reperfusion injury in rats. J Neurol Sci 2014; 337(1-2):74-79.

Chakraborty M, Kamath JV. Pharmacodynamic interaction of green tea extract with hydrochlorothiazide against ischemia-reperfusion injury-induced myocardial infarction. J Adv Pharm Technol Res. 2014; 5(3):134–139.

Zhang S, Qi Y, Xu Y, Han X, Peng J, et al. Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation. Neurochem Int 2013; 63(5):522-532.

Sarkaki A, Hajipour S, Mansouri MT, Pilevarian A, Rad MR Pomegranate seed hydroalcoholic extract improves memory deficit due to permanent cerebral hypoperfusion/ischemia in male rats. Health Med 2013; 7(3): 863-871.

Jittiwat J, Wattanathorn J. Ginger pharmacopuncture improves cognitive impairment and oxidative stress following cerebral ischemia. J Acupunct Meridian Stud. 2012; 5(6):295-300.

Xiang J, Lan R, Tang YP, Chen YP, Cai DF. Apocynum venetum leaf extract attenuates disruption of the blood–brain barrier and upregulation of matrix metalloproteinase-9/-2 in a rat model of cerebral ischemia-reperfusion injury. Neurochem Res. 2012; 37(8):1820-1828.

Published

20-09-2020
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How to Cite

1.
Singh S, Shafi S, Shrivastav A, Khan S, Ahmad T, Khan NA. A Review on Herbal Plants used in Brain Ischemic and Reperfusion Injury. J. Drug Delivery Ther. [Internet]. 2020 Sep. 20 [cited 2025 May 17];10(5):376-9. Available from: https://www.jddtonline.info/index.php/jddt/article/view/4415

How to Cite

1.
Singh S, Shafi S, Shrivastav A, Khan S, Ahmad T, Khan NA. A Review on Herbal Plants used in Brain Ischemic and Reperfusion Injury. J. Drug Delivery Ther. [Internet]. 2020 Sep. 20 [cited 2025 May 17];10(5):376-9. Available from: https://www.jddtonline.info/index.php/jddt/article/view/4415

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