Preliminary Physicochemical screening of bioactive based nanocarrier system
Abstract
The roles of oxidative stress (OS) in neurodegenerative diseases, the manipulation of ROS levels may represent a treatment option to slow down neurodegeneration and alleviate associated symptoms. Many compounds with antioxidant properties have been examined for their potential to attenuate neurodegenerative symptoms. The drawbacks of oral administration of antioxidants are limited entry across the blood–brain barrier. Most molecules suffer from problems of solubility, bioavailability or the ability to cross the blood brain barrier and hence nanomedicine needs to be explored. The excipient components (Carrier oil, surfactant and co-surfactant) were selected on the basis of their miscibility in alpha-pinene. The miscibility of the drug was assessed in 25 carrier oil, 5 surfactant and 6 Co-surfactant. Total 250 self-nanoemulsifying nanoformulations (SENF) compositions were prepared from the selected excipients and were preliminary screened on the basis of the number of flask inversion, emulsification time and stability up to 72 hours. Three SNEDDS formulation compositions finally selected for the development and optimization for excipient concentration as these combinations was found to possessed no. of flask inversion and emulsification time.
Keywords: Self-nanoemulsifying nanoformulations, Bioavailability, Alpha-pinene, oxidative stress, blood–brain barrier
Keywords:
Self-nanoemulsifying nanoformulations, Bioavailability, Alpha-pinene, oxidative stress, blood–brain barrierDOI
https://doi.org/10.22270/jddt.v10i1.4378References
Roselan MA, Ashari SE, Faujan NH, Mohd Faudzi SM, Mohamad R. An Improved Nanoemulsion Formulation Containing Kojic Monooleate: Optimization, Characterization and In Vitro Studies. Molecules. 2020 Jan; 25(11):2616.
Kassem AA, Abd El-Alim SH, Salman AM, Mohammed MA, Hassan NS, El-Gengaihi SE. Improved hepatoprotective activity of Beta vulgaris L. leaf extract loaded self-nanoemulsifying drug delivery system (SNEDDS): in vitro and in vivo evaluation. Drug Development and Industrial Pharmacy. 2020 Oct 2; 46(10):1589-603.
Chatterjee B, Hamed Almurisi S, Ahmed Mahdi Dukhan A, Mandal UK, Sengupta P. Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view. Drug delivery. 2016 Nov 21; 23(9):3639-52.
Gupta BK, Kumar S, Kaur H, Ali J, Baboota S. Attenuation of oxidative damage by coenzyme Q10 loaded nanoemulsion through oral route for the management of Parkinson's disease. Rejuvenation research. 2018 Jun 1; 21(3):232-48.
Albarracin SL, Stab B, Casas Z, Sutachan JJ, Samudio I, Gonzalez J, Gonzalo L, Capani F, Morales L, Barreto GE. Effects of natural antioxidants in neurodegenerative disease. Nutritional neuroscience. 2012 Jan 1; 15(1):1-9.
Aquilano K, Baldelli S, Rotilio G, et al. Role of nitric oxide synthases in Parkinson’s disease: a review on the antioxidant and anti-inflammatory activity of polyphenols. Neurochem. Res. 2008; 33:2416-26.
Lucio M, Lima JL, Reis S. Drug-membrane interactions: significance for medicinal chemistry. Current medicinal chemistry. 2010 Jun 1; 17(17):1795-809.
Chen JC, Li LM, Gao JQ. Biomaterials for local drug delivery in central nervous system. International Journal of pharmaceutics. 2019; 560:92-100.
Soares TB, Loureiro L, Carvalho A, Oliveira ME, Dias A, Sarmento B, Lúcio M. Lipid nanocarriers loaded with natural compounds: Potential new therapies for age related neurodegenerative diseases?. Progress in neurobiology. 2018 Sep 1; 168:21-41.
Diane JM, Burgess J. Vitamin E nanoemulsions characterization and analysis. International journal of pharmaceutics. 2014 Apr 25; 465(1-2):455-63.
Shakeel F, Shazly GA, Raish M, Ahmad A, Kalam MA, Ali N, Ansari MA, Elosaily GM. Biological investigation of a supersaturated self-nanoemulsifying drug delivery system of Piper cubeba essential oil. RSC advances. 2015; 5(127):105206-17.
Khoo SM, Humberstone AJ, Porter CJ, Edwards GA, Charman WN. Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine. International journal of pharmaceutics. 1998 Jun 1; 167(1-2):155-64.
Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M. Development and bioavailability assessment of ramipril nanoemulsion formulation. European journal of pharmaceutics and biopharmaceutics. 2007 May 1; 66(2):227-43.
El-Badry M, Haq N, Fetih G, Shakeel F. Solubility and dissolution enhancement of tadalafil using self-nanoemulsifying drug delivery system. Journal of oleo science. 2014; 63(6):567-76.
Parmar N, Singla N, Amin S, Kohli K. Study of cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded (SNEDDS) self nanoemulsifying drug delivery system. Colloids and Surfaces B: Biointerfaces. 2011 Sep 1; 86(2):327-38.
Xi J, Chang Q, Chan CK, Meng ZY, Wang GN, Sun JB, Wang YT, Tong HH, Zheng Y. Formulation development and bioavailability evaluation of a self-nanoemulsified drug delivery system of oleanolic acid. Aaps Pharmscitech. 2009 Mar 1; 10(1):172-82.
Zhao T. Self-nanoemulsifying drug delivery systems (SNEDDS) for the oral delivery of lipophilic drugs (Doctoral dissertation, University of Trento England, 2015).
Baker RC, Florence AT, Ottewill RH, Tadros TF. Investigations into the formation and characterization of microemulsions. II. Light scattering conductivity and viscosity studies of microemulsions. Journal of colloid and interface science. 1984 Aug 1; 100(2):332-49.
Shakeel F, Haq N, Alanazi FK, Alsarra IA. Polymeric solid self-nanoemulsifying drug delivery system of glibenclamide using coffee husk as a low cost biosorbent. Powder technology. 2014 Apr 1; 256:352-60.
Singh AK, Chaurasiya A, Awasthi A, Mishra G, Asati D, Khar RK, Mukherjee R. Oral bioavailability enhancement of exemestane from self-microemulsifying drug delivery system (SMEDDS). Aaps Pharmscitech. 2009 Sep 1;10(3):906-16.
Balakumar K, Raghavan CV, Abdu S. Self nanoemulsifying drug delivery system (SNEDDS) of rosuvastatin calcium: design, formulation, bioavailability and pharmacokinetic evaluation. Colloids and Surfaces B: Biointerfaces. 2013 Dec 1; 112:337-43.
Simonazzi A, Cid AG, Villegas M, Romero AI, Palma SD, Bermúdez JM. Nanotechnology applications in drug controlled release. InDrug targeting and stimuli sensitive drug delivery systems 2018 Jan 1 (pp. 81-116). William Andrew Publishing.
Badran MM, Taha EI, Tayel MM, Al-Suwayeh SA. Ultra-fine self nanoemulsifying drug delivery system for transdermal delivery of meloxicam: Dependency on the type of surfactants. Journal of Molecular Liquids. 2014 Feb 1; 190:16-22.
Singh AK, Yadav TP, Pandey B, Gupta V, Singh SP. Engineering nanomaterials for smart drug release: recent advances and challenges. InApplications of targeted nano drugs and delivery systems 2019 Jan 1 (pp. 411-449). Elsevier.
Kharat M, Aberg J, Dai T, McClements DJ. Comparison of Emulsion and Nanoemulsion Delivery Systems: The Chemical Stability of Curcumin Decreases as Oil Droplet Size Decreases. Journal of Agricultural and Food Chemistry. 2020 Jul 31; 68(34):9205-12.
Millar SA, Maguire RF, Yates AS, O’Sullivan SE. Towards Better Delivery of Cannabidiol (CBD). Pharmaceuticals. 2020 Sep; 13(9):219.
Published
Abstract Display: 398 
PDF Downloads: 520 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.