Hematological Changes During All trimesters in Normal Pregnancy
Abstract
Aim: The objective of the study is to evaluate the normal physiological changes in values of major hematological parameters occur during the normal pregnancy
Method: Blood samples (5ml EDTA) were taken voluntarily after consent obtained from from 50 healthy pregnant women from 20 to 40 years old who presented themselves at Khartoum teaching during their regularly follow-up. Questionnaires and direct interview were used to collect demographic and clinical data. CBC and part differential (WBC, RBC, Hb, PCV, and platelets), were measured by Sysmex and the plasma clotting time PT and PTT were measured by coagulometer.
Results: W'BCs mean value was 7.580 cell/mm3, RBCs mean value was 4.1 x l012/L, Hb mean value was 11.79 g/dL, Platelets mean value was 256 x109/L, PT mean value of the study group was 13.40 seconds and PTT mean value was 36.20 seconds.
Conclusion: It can be concluded that no statistical significance in RBCs, HB, platelets. PT and PTT between pregnant women in the three different trimesters while white WBCs count showed different decreased but not statistical significant among the three groups, the highest value was round in the second group followed by the third group and the lowest value found in the first group.
Keywords: Normal pregnancy, Hematological Changes, Pregnancy trimesters
DOI
https://doi.org/10.22270/jddt.v10i2.3958References
- Soma-Pillay P, Nelson-Piercy C, Tolppanen H, Mebazaa A. Physiological changes in pregnancy. Cardiovasc J Afr. 2016;27(2):89–94. doi:10.5830/CVJA-2016-021.
- Boundless. “Introduction to Pregnancy and Human Development.” Boundless Anatomy and Physiology. Boundless, 05 Aug. 2015. Retrieved 28 Sep. 2015
- Bauer, K. A., & Tirnauer, J. S. (2018). Maternal adaptations to pregnancy: Hematologic changes. UpToDate.
- Cunningham FG. Normal reference ranges for laboratory values in pregnancy. UpToDate. 2014.
- Kraemer, Klaus, and Michael B. Zimmermann, eds. Nutritional anemia. Basel: Sight and Life press, 2007.
- Paidas, Michael J., and Nazli Hossain. "Hematologic changes in pregnancy."Hemostasis and thrombosis in obstetrics and gynecology UK: Wiley-Blackwell(2011): 1-11.
- Prisco, Domenico, Gabriele Ciuti, and Michela Falciani. "Hemostatic changes in normal pregnancy." Hematology Meeting Reports (formerly Haematologica Reports). 2009; 1(10).
- Ramsay Margaret. Normal hematological changes during pregnancy and the puerperium. In: Pavord S, Hunt B, editors. The obstetric hematology manual. Cambridge: Cambridge University Press; 2010. pp. 1–11
-Kjell H, Svendsen E, and Abildgaard U. "The HELLP syndrome: clinical issues and management. A review." BMC pregnancy and childbirth 2009; 9(1):8.
- Chandra S, Tripathi AK, Mishra S, Amzarul M, Vaish AK. Physiological Changes in Hematological Parameters During Pregnancy. Indian Journal of Hematology & Blood Transfusion. 2012; 28(3):144-146. doi:10.1007/s12288-012-0175-6.
- Li H., et al. "[Correlation of hemogram changes during pregnancy of healthy women with postpartum blood transfusion]." Zhongguo shi yan xue ye xue za zhi/Zhongguo bing li sheng li xue hui= Journal of experimental hematology/Chinese Association of Pathophysiology 2012; 20.5:1240-1242.
- Babiker HI., Hiba AA, and Sana E. Abdalla. "Prothrombin Time, Activated partial Thromboplastin Time and Platelets Count in Pregnant Females and Postpartum Period with Deep Venous Thrombosis." International Journal of Hematological Disorders 2014; 1(1):41-44.
- Amah-Tariah F. S., Ojeka SO, and Dapper DV. "Haematological values in pregnant women in Port Harcourt, Nigeria II: Serum iron and transferrin, total and unsaturated iron binding capacity and some red cell and platelet indices." (2014).
- Akinbami A. A., Ajibola S. O., Rabiu K. A., Adewunmi A. A., Dosunmu A. O., Adediran A., Osunkalu V. O., Osikomaiya B. I., and Ismail K. A. Hematological profile of normal pregnant women in Lagos, Nigeria. Inter. J. Women Health, 2013; 5:227-232.
- Akingbola T., Adewole I. F., Adesina O. A., Afolabi K. A., Fehintola F. A., Bamgboye E. A., Aken'ova Y. A., Shokunbi W. A., Anwo J. A., and Nwegbu M. M. Haematological Profile of healthy pregnant women in Ibadan, south western Nigeria. J. Obstet. Gynaecol., 2006; 26(8):763- 769.
- Azab, E.A., Albasha, M.O. and Elhemady, S.Y., Haematological parameters in pregnant women attended antenatal care at sabratha teaching hospital in Northwest, Libya. American Journal of Laboratory Medicine, 2017; 2(4):60.
- Boehlen F, Hohlfeld P, Extermann P et al. Plate let count atterm pregnancy are appraisal of the threshold. Obstet Gynecol 2000; 95:29-33.
- Babker, Asaad Mohammed Ahmed Abd Allah, and Fath EIrahman Mahdi Hassan Gameel. "Molecular Characterization of Prothrombin G20210A gene Mutations In pregnant Sudanese women with spontaneous recurrent abortions."Rawal Medical Journal 2015; 40(2):207-209.
- Avwioro OG, Ezeobi JO, Oduola T, Fakunle OO., Prothrombin time and Activated Partial Thromboplastin time in Pregnant Women in Southern Nigeria. J App Pharm Sci. 2013; 3(06):179-181.
- Cerneca F, Ricci G, Simeone R, et al ‘Coagulation and fibrinolysis changes in normal pregnancy. Increased levels of procoagulants and reduced levels of inhibitors during pregnancy induce a hypercoagulable state, combined with a reactive fibrinolysis’ Eur J Obstet Gynecol Reprod Biol. 1997; 73(1):31-6.
- Erhabor, O., et al. "Some hemostatic parameters in women with obstetric hemorrhage in Sokoto, Nigeria." International journal of women's health 2013; 5:285.
- Kaur S, Khan S, Nigam A. Hematological profile and pregnancy: a review. Int J Adv Med 2014; 1:68-70.
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