FORMULATION AND EVALUATION OF METOCLOPRAMIDE RAPIDLY DISINTEGRATING TABLETS

Abstract

Metoclopramide an effective antiemetic; acting on the CTZ, blocks apomorphine induced vomiting. Rapidly disintegrating tablets of metoclopramide hydrochloride were prepared by mass extrusion technique using three different superdisintegrants Sodium Starch Glycolate, Avicel Ph 102, L-HPC. Pre-compression parameters and post-compression parameters were evaluated for all the nine formulations. Angle of repose and % compressibility showed good flowability in all the formulations. Weight variation was found within limits and drug content of all the formulations was found in the range of 9.700 mg - 9.925 mg in each tablet. The hardness of all the formulations was almost uniform and possessed good mechanical strength with sufficient hardness. The wetting time in all the formulation was fast. Formulations F3 containing sodium starch glycolate 10% & F6 containing Avicel ph 102 10% tablets disintegrated rapidly to release the drug. In vitro release studies revealed that 96% of drug releases from SSG, MCC (90%), and L-HPC (85%) for all the formulations were within 15 min. Based on above results, three formulations F3, F6, F9 were selected for stability studies these formulations showed not much variation in any parameter even after the period of 30 days, formulations F3, F6, F9 are found to be stable and retained their original properties. Thus, it may be concluded that formulation containing sodium starch glycolate as superdisintegrants is fulfilling all the parameters satisfactorily. It showed excellent in vitro disintegration, in vitro dispersion time, compared to other superdisintegrants. And the rapidly disintegrating tablets can be prepared by mass extrusion technique