DEVELOPMENT AND EVALUATION OF FINASTERIDE-LOADED NANOPARTICLES FOR POTENTIAL TREATMENT OF ALOPECIA
Abstract
The androgenetic alopecia is a very common dermatological disorder affecting both men and women. In men, over age of 50 to more than 95% of them the hair loss is attributed to androgenetic Alopecia (AGA). In women AGA is less common with about 40% of women suffer from some degree of hair loss especially after menopause. Oral finasteride (FNS), a synthetic 4-aza-3-oxosteroid compound with low aqueous solubility. Blocks the peripheral conversion of testosterone to dihydrotestosterone (DHT). FDA has approved only minoxidil and finasteride for treatment of alopecia. Nanoparticles made up of biodegradable polymers have great potential for delivery of drug at target site, reduces the side effects and improve bioavailability of drugs. Solid lipid nanoparticles was prepared using lecithin/chitosan by solvent emulsification method followed by sonication. Finasteride loaded Lecithin Chitosan Nanoparticles (LCN) was characterized and optimized by parameters like particle size, zeta potential, surface morphology entrapment efficiency, in vitro release and stability studies. The optimized formulation was then further evaluated for the pharmacokinetic studies in Wistar rats. Finasteride -loaded LCN of particle size 245.5±7.60 nm, zeta potential 36±0.548 mV and entrapment efficiency 71.73±1.460%. showed optimum bioavailability in Wistar rats, maximum solubility and also showed good stability. This study confirm that the prepared using Lecithin Chitosan Nanoparticles (LCN) improve bioavailability and solubilty of the drug.
Keywords: Finasteride /pharmacokinetics. Finasteride /formulations. Finasteride /bioavailability. lecithin/chitosan. Lecithin Chitosan Nanoparticles (LCN).
Keywords:
Finasteride /pharmacokinetics. Finasteride /formulations. Finasteride /bioavailability. lecithin/chitosan. Lecithin Chitosan Nanoparticles (LCN)., Finasteride /pharmacokinetics, Finasteride /formulations, Finasteride /bioavailability, lecithin/chitosan, Lecithin Chitosan Nanoparticles (LCN)DOI
https://doi.org/10.22270/jddt.v8i2.3616References
Soma D, Attari Z, Reddy MS, Damodaram A, Koteshwara KB. Solid lipid nanoparticles of irbesartan: preparation, characterization, optimization and pharmacokinetic studies. Braz. J. Pharm. Sci. 2017; 53(1):e15012.
Cheung R, Ng T, Wong J, Chan W. Chitosan an Uodate on Potential Biomedical and Pharmaceutical Applications. Marine drugs. 2015; 13(8):5156- 86.
Bansal M, Rathore P, Goel B. Quantitative Determination of Finasteride from Tablet Formulation by. 2013; 1:48-50.
Chauhan P, Tyagi BK, Herbal novel drug delivery systems and transfersomes, Journal of Drug Delivery and Therapeutics 2018; 8(3):162-168. https://doi.org/10.22270/jddt.v8i3.1772
Sonvico F, Cagnani A, Rossi A, et al. Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction. Int J Pharm. 2006; 324(1):67-73.
Hafner A, Lovrić J, Voinovich D, Filipović-Grčić J. Melatonin-loaded lecithin/chitosan nanoparticles: Physicochemical characterisation and permeability through Caco-2 cell monolayers. Int J Pharm. 2009; 381(2):205- 213.
Ahmed TA. Preparation of finasteride capsules-loaded drug nanoparticles : formulation, optimization, in vitro , and pharmacokinetic evaluation. Int J Nanomedicine. 2016; 11:515-527.
Maurya SD, Arya RKK, Rajpal G, Dhakar RC, Self-micro emulsifying drug delivery systems (SMEDDS): a review on physico-chemical and biopharmaceutical aspects. Journal of Drug Delivery and Therapeutics 2017; 7(3):55-65
Madheswaran T, Baskaran R, Yong CS, Yoo BK. Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants. AAPS PharmSciTech. 2014; 15(1):44-51.
Mhurchu CN, Poppitt SD, Mcgill A, et al. The effect of the dietary supplement, Chitosan , on body weight : a randomised controlled trial in 250 overweight and obese adults. 2004; 1149-1156.
Sachan AK, Gupta A, Arora M, Formulation & characterization of nanostructured lipid carrier (NLC) based gel for topical delivery of etoricoxib, Journal of drug delivery and therapeutics 2016; 6(2):4-13
Scholfield CR, Regional N. ~ Composition of Soybean Lecithin. 1981; 58(10):889-892. https://en.wikipedia.org/wiki/Finasteride(18-06-2018).
https://www.drugbank.ca/drugs/DB01216 (04-07-2018). 8. https://pubchem.ncbi.nlm.nih.gov/compound/finasteride#section=Top(16-07- 2018). 9. https://en.wikipedia.org/wiki/Lecithin ( 17-07-2019)
Patil SG, Wagh AS, Pawara RC, Ambore SM. Standard Tools for Evaluation of Herbal Drugs : An Overview. Pharma Innov. 2013; 2(9):2-7.
Madheswaran T, RBaskaran, Sundaramoorthy P, Yoo BK. Enhanced skin permeation of 5alpha-reductase inhibitors entrapped into surface-modified liquid crystalline nanoparticles. Arch Pharm Res. 2015; 38(4):534-542.
Gangrade D, Sharma A, Bakshi S. Determination of polymorphic forms of finasteride by XRPD, FT-IR and DSC techniques. world J Pharm Sci. 2015; 9(3):1892-1898.
Zhou XL, Sun PN, Bucheli P, Huang TH, Wang D. FT-IR methodology for quality control of arabinogalactan protein (AGP) Extracted from green tea (Camellia sinensis). J Agric Food Chem. 2009; 57(12):5121-5128.
Alsenz J, Kansy M. High throughput solubility measurement in drug discovery and development. Adv Drug Deliv Rev. 2007; 59(7):546-567.
Mady FM, Aly UF. Experimental, molecular docking investigations and bioavailability study on the inclusion complexes of finasteride and cyclodextrins. Drug Des Devel Ther. 2017; 11:1681-1692.
Matias JR, Malloy V, Orentreich N. Animal models of androgen-dependent disorders of the pilosebaceous apparatus. Arch Dermatol Res. 2004; 281(4):247- 253.
Patel S, Nag MK, Sharma V, Chauhan NS, Dixit VK. A comparative in vivo and in vitro evaluation of hair growth potential of extracts and an isolate from petroleum ether extract of Cuscuta reflexa Roxb. Beni-Suef Univ J Basic Appl Sci. 2014; 3(3):165-171.
Published
Abstract Display: 405 
PDF Downloads: 491 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.