Formulation and evaluation of Zidovudine alginate microspheres
Abstract
The objective of the present study was to prepare and evaluate microspheres for the controlled release of Zidovudine from the prepared microspheres using different polymers. The microspheres were prepared by ionic gelation method. The prepared microspheres were characterized for FTIR, scanning electron microscopy (SEM), the percentage drug content, entrapment efficiency, and in vitro dissolution studies. Accelerated stability studies were also carried out for the formulations. The microspheres were spherical in shape and free flowing. The entrapment efficiency was varying from 76 to 86%. The release of drug from the microspheres was extended up to 8 to 12 hours. FTIR studies showed the stable character of Zidovudine in the microspheres. SEM studies revealed that the microspheres were porous in nature. The release kinetics studies revealed that the prepared microspheres were best fitted to the zero order for all eight formulations and peppa’s model. The release kinetics data and characterization studies indicated that the drug release from microspheres was diffusion – controlled and the microspheres were stable in nature.
Keywords: Zidovudine, microspheres, controlled release, stability, ionic gelation, entrapment efficiency.
Downloads
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.