Anti-Inflammatory Activity of Mimosa hamata (Willd.)

Authors

  • N. I. Khan
  • B.C. Hatapakki

Abstract

Anti-inflammatory activity of ethanolic extract of roots, stems and leaves Mimosa hamata was investigated at the doses of 200 and 400 mg/kg using carrageenan induced paw edema and cotton pellet granuloma technique in albino rats. The stem extracts showed significant activity in dose dependent manner as compared to control group. The observations suggested that the extract of M. hamata were effective in exudative and proliferative phases of inflammation i.e. in acute and chronic inflammation. The results obtained indicate that M. hamata has an anti-inflammatory activity that supports the folk medicinal use of the plant.

Keywords: Mimosa hamata, anti-inflammatory activity, carrageenan induced paw edema, cotton pellet granuloma.

DOI

https://doi.org/10.22270/jddt.v9i5-s.3596

Author Biographies

N. I. Khan

  • Department of Pharmacology, Sahyadri College of Pharmacy, Methwade, Maharashtra, INDIA- 413307.

B.C. Hatapakki

Department of Pharmacognosy, P.S.P.S.'s Indira Institute of Pharmacy, Sadavali (Devrukh), Maharashtra, INDIA- 415804.

References

Harsh M. Text book of Pathophysiology. 5thed. New Delhi: Jaypee publication. 2005. p. 126-34.

Renu Singh, Y. T. Jasrai. Mimosa hamata (Willd.), a plant with antipathogenic properities, International Journal of Medicinal and Aromatic Plants, Vol. 2, No.4, pp. 677-682, December 2012

Barneby R.C. 1992 Sensitive Censitae: A description of the genus Mimosa Linnaeus (Mimosaceae) in the new world, In Memoirs of the New York Botanical Garden,Vol 65

Hussain N, Modan MH, Shabbir S.G, Zaidi SAH. Antimicrobial principlesin Mimosa hamata. J. Nat. Prod.1979;42:525-527 pp.

Nadkarni A.K, Nadkarni K.M., Indian Materia Medica. Popular Book Depot, Bombay 1954.

Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. CSIR, New Delhi 1956.

Mukadam DS, Balkhande LD, Umalkar GV. Antifungal activities in deproteinized leaf extract of weeds and non-weeds. Indian J. Microbiol. 1976;16:78-79 pp.

Jain R, Arora R, Alam S, Jain SC. Pharmacological evaluation of Mimosa hamata roots. Fitoterapia1997a;68:377-378 pp.

Jain SC, Jain R, Singh R. Antioxidant activity of mimonosides isolated from in vitro regenerated plants of Mimosa hamata (Willd.) Indian J. Plant Physiol. 2009;14: pp124-129

Wagner, G., Blatt, S., (1996): Plant drug analysis, a thin layer chromatography, Atlas,2nd Ed, CS Pringer Verlag, pp. 352-355

Ecobichon D.J., (1999): The basis of toxicology testing 2nd edn, Newyork, CRC press, pp 43-46.

OECD/OCED 423 guidelines for testing chemicals (Acute oral toxicity – fixed dose procedure). Adopted 23rd March 2006. [cited 2008 June 20]; Available from: URL;www.oecd.org.

S Parvej, Kumkum Mathur, M Goyal, S K Yadav, Mimosa hamata Willd. : A Review on Ethnobotanical, Phytochemical and Pharmacological Profile International Journal of Pharmaceutical & Biological Archives 2016; 8 (1): 10-12

Winter CA, Risley EA, Nuss GW (1962) Carrageenin-induced oedema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 111:544–547

Winter CA, Porter CC. Effect of alteration inside chain upon antiinflammatory and liver glycogen activities in hydrocortisone ester. J. Am. Pharm. Assoc., 46: 515-519. 1957

Lowry OH, Rosebrough NJ, Far AL, Randall RJ (1951). Protein measurement with the Folin phenol reagent. J. Biol . Chem. 193: 265- 275.

Castro J, Saseme H, Sussman H, Bullette P (1968). Diverse effect of SKF 52 and antioxidants on CCL4 induced changes in liver microsomal P-450 content and ethylmorphine metabolism. Life Sci.7: 129-136.

Della Loggia A, Tubaro A, Dri P, Zilli C, Del Negro P (1968). The role of flavonoids in the anti-inflammatory activity of Chamomilla recutita. Clin. Biol. Res. 213: 481-486

Alcaraz MJ, Jimenez MJ (1988). Flavonoide, an anti-inflammatory agents. Fitoterapia 59: 25-38.

Bhattacharya S, Pal S, Nag Chaudhauri AK (1992). Pharmacological studies of the anti-inflammatory profile of Mikania cordata (Burm) B. L. Robonson root extract in rodents. Phytotherapy Res. 6: 255-301

Swingle KF (1974). Anti-inflammatory agents. In: Chemistry and Pharmacology, Vol. 2, Academic Press, New York, pp. 33-47.

Published

2019-10-15
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How to Cite

1.
Khan NI, Hatapakki B. Anti-Inflammatory Activity of Mimosa hamata (Willd.). J. Drug Delivery Ther. [Internet]. 2019 Oct. 15 [cited 2026 Feb. 2];9(5-s):34-9. Available from: https://www.jddtonline.info/index.php/jddt/article/view/3596

How to Cite

1.
Khan NI, Hatapakki B. Anti-Inflammatory Activity of Mimosa hamata (Willd.). J. Drug Delivery Ther. [Internet]. 2019 Oct. 15 [cited 2026 Feb. 2];9(5-s):34-9. Available from: https://www.jddtonline.info/index.php/jddt/article/view/3596