Development and Validation of UV-Spectrophotometric Method for Estimation of Metformin Hydrochloride and Pioglitazone in Tablet Dosage Form
Abstract
Simple, sensitive, rapid and accurate UV spectroscopic methods have been developed for the estimation of metformin hydrochloride and pioglitazone in tablet dosage forms. Simultaneous estimation and dual-wavelength methods were developed and validated using solvent methanol. Both drugs show linearity at 5-40 µg/ml for both methods. The suggested techniques have been effectively implemented in pharmaceutical formulations to the evaluation of quoted drugs. Recovery research was conducted to verify the method's accuracy, precision. The techniques have been validated under ICH guidelines.
Keywords: Metformin hydrochloride, Pioglitazone, Simultaneous estimation method and Dual wavelength method.
DOI
https://doi.org/10.22270/jddt.v9i4-A.3499Published
2019-08-30
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Joshi RS, Nangare AK, Sanap DS, Sase SM. Development and Validation of UV-Spectrophotometric Method for Estimation of Metformin Hydrochloride and Pioglitazone in Tablet Dosage Form. J. Drug Delivery Ther. [Internet]. 2019 Aug. 30 [cited 2026 Feb. 2];9(4-A):381-4. Available from: https://www.jddtonline.info/index.php/jddt/article/view/3499
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How to Cite
1.
Joshi RS, Nangare AK, Sanap DS, Sase SM. Development and Validation of UV-Spectrophotometric Method for Estimation of Metformin Hydrochloride and Pioglitazone in Tablet Dosage Form. J. Drug Delivery Ther. [Internet]. 2019 Aug. 30 [cited 2026 Feb. 2];9(4-A):381-4. Available from: https://www.jddtonline.info/index.php/jddt/article/view/3499
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