EFFECT OF CAESALPINIA BONDUCELLA L. ON ULCER AND GASTRIC SECRETIONS IN PYLORUS LIGATED RAT MODEL
Abstract
In the present study, aqueous extract Caesalpinia bonducella (CBD; Karanjwa) was evaluated for antiulcer and antisecretory potential in pylorus ligated rat model. CBD is an important medicinal plant having multiple therapeutic properties viz. topical anti-inflammatory, antipyretic, antidiuretic, anthelmintic and antibacterial, anticonvulsant, anti-anaphylactic and antidiarrhea, antiviral, antiasthmatic, antiamoebic and antiestrogenic effects. Phytochemical screening of the aqueous extracts showed the presence of alkaloids, saponins, flavonoids, triterpenes, tannins and steroids. Ulcer was induced by pylorus ligation in Wistar rats. The aqueous extract from the leaves of CBD were tested orally at the doses of 500, 750 and 1000 mg/kg. The aqueous extract of CBD (500, 750 and 1000 mg/kg) produced significant antiulcer and antisecretory effects, respectively. Observations of the present study could justify, at least partially, the inclusion of this plant in the management of gastric disorders in traditional medicine.
Keywords: Pylorus ligation, total acidity, free acidity.
DOI
https://doi.org/10.22270/jddt.v2i5.304
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