BROMOCRIPTINE - A NOVEL APPROACH FOR MANAGEMENT OF TYPE 2 DIABETES MELLITUS
Abstract
Quick release formulation of Bromocriptine mesylate is recently been approved by FDA (Food and Drug Administration) for the treatment of type 2 diabetes mellitus. Early morning dose of bromocriptine mesylate reduces the plasma prolactin level and increases the hypothalamic dopaminergic drive thereby reducing postprandial plasma glucose, triglyceride, and free fatty acid concentrations. Conventional preparation of bromocriptine are available in 2.5 mg or 5 mg tablets used for hyperprolactinemia and suppression of lactation. Studies have shown that quick release bromocriptine given in dose of 0.8-4.8 mg per day for a period of 6 month have successfully achieved target blood sugar. So the drug is well tolerated in antidiabetic dosage with mild side effects like nausea vomiting and fatigue. The central mechanism of action , good side effect profile and its effects to reduce adverse cardiovascular outcomes make it an attractive option for treatment of type 2 diabetes.
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Key words : Bromociptine, diabetes, insulin resistance, quick release formulation, prolactinDOI
https://doi.org/10.22270/jddt.v2i5.296
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