Formulation and Evaluation of Clindamycin phosphate Niosomes by using Reverse Phase Evaporation Method
Abstract
The formulate and evaluate Niosome drug delivery system for Clindamycin phosphate to increase its effectiveness by increasing penetration through skin and reducing its side effects Sorbitan esters which are Non-ionic surfactants was the key ingredient which forms vesicles upon hydration with aqueous media. Cholesterol was used to make vesicle stable and rigid. Different formulations were preparing by using different sorbitan ester and changing the ratio of surfactant and Cholesterol. Clindamycin Phosphate is an antibiotic widely used for the treatment of acne. The pseudomonas colitis occurs with oral dosage form while in topical dosage forms it has side effects like irritation, skin rash, itching etc. its topical bioavailability is also less. An attempt has been made to overcome these limitations for the preparation to prepare niosomes of clindamycin phosphate as well as for the enhanced delivery through skin by the variation in cholesterol level. Niosome were prepared by reverse phase evaporation method using span 60 as polymer. The compatibility of drug and polymer is analyzed by using FTIR and DSC method. There was no interaction detected by FTIR, DSC study. Further the prepared niosomes were evaluated for drug entrapment efficiency, drug content, and in vitro drug release. Amongst all the formulation batch 3 shows the best release when compared to other batch. SEM (Scanning electron microscopy) revealed that niosomes were spherical and porous. Finally it was concluded that clindamycin phosphate have been found suitable for controlled release formulation due to its bioavailability and biodegradability and thus lead to improved patient compliance.
Keywords: Niosomes, Clindamycin Phosphate, Reverse phase evaporation method, Span60.
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References
2. Goodman and Gilman’s , The pharmacological Basis of therapeutics, 10th edition McGraw Hill Med. Pub. Div. New York, 2001, 777- 779
3. Vyas J, Vyas P, Savant K, “ Formulation and evaluation of Topical Niosomal Gel ofErythromycin”, International journal of Pharmacy and Pharmaceutical Sciences, 2011,3,123-126
4. Government of India Ministry Health and Family Welfare. Indian Pharmacopeia. .
5. British Pharmacopeia. London: The stationery office. 2001; 77(2):22-31.
6. Martindale: The Extra pharmacopeia, 31st ed. London: The royal Pharmaceutical society. 1996.
7. Dubey M, Kesharwani P, Tiwari A, Chandel R, Raja K, Sivakumar T. Formulation and evaluation of floating microsphere containing anti-diabetic drug. International Journal of pharmaceutical and chemical Sciences. 2012; 1(3):1387-1396.
8. Sawakar S, Dhurvey Y, Sakaekar D. Improvement in micromeritics properties of fenofibrate by spherical crystallization technique. International Journal of Biopharmaceutics. 2012; 3(2):89-95.
9. S.Saumya , “Niosome: A Role in targeted drug delivery” International journal of pharmaceutical science and research, Jan 2013, 550-557
10. Nasir A, SL H and Amanpreet K, “ Niosome: an excellent tool for drug delivery”, international journal of research in pharmacy and chemistry, 2012,481-487
11. Vyas SP, Khar RK. Targeted and controlled drug delivery novel carrier systems. New Delhi: cbs publishers and distributors; 2004:3- 13, 40.
12. Rastogi Aruna. Novel drug delivery system. Pharma tutor- art- 1652.
13. Hillery Anya M, Lloyd Andrew W, James Swarbrick. Drug delivery and targeting for pharmacists and pharmaceutical scientists. Crc press; 2010:63- 82.
14. Azmin MN, Florence AT, Handjani-Vila R.M, Stuart JFB, Vanlerberghe G and Whittaker JS. The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. J. Pharm.Pharmacol. 1985; 37: 237-242.
15. IF Uchegbu; AT Florenc. Adv. Colloid Interface Sci., 1995, 58(1), 1-55.
16. Arunothayanum.P, I. F. Uchegbu, D. Q. M. Craig, J. A. Turton and A. T. Florence In vitro/In vivo characterization of polyhedral niosomes International Journal of Pharmaceutics, Volume 183, Issue 1, 10 June 1999, 57-61.
17. Vyas SP, Khar RK. Targeted and controlled drug delivery novel carrier systems. New delhi: cbs publishers and distributors; 2004:3- 13, 40.
18. Chhotalal Ashara Kalpesh al. Vesicular drug delivery system: a novel approach. Mintage Journal of Pharmaceutical and Medical Sciences.2014; 3(3):1- 14
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