A Review on Microsponge as Emerging Drug Delivery System
Abstract
A microsponge delivery system will entrap a wide variety of active pharmaceutical ingredients and then release them onto the skin over a time and additionally in response to different stimuli including rubbing, moisture, pH, friction, or ambient skin temperature. It can also be used for controlled oral delivery of drugs using water-soluble, water-insoluble and bio-erodible polymers. The primary aim of any drug delivery system is to provide a therapeutic quantity of drug to the suitable site in the body, to punctually achieve and retain the desired drug concentration. The elemental application of the microsponge technology arises as of the difficulty experienced with predictable formulations in release active ingredients over an extended period of time. Microsponges also enhanced bioavailability of active ingredient and increase the solubility of the poorly water-soluble drug. Microsponge is providing some advantages like controlled release and extended release of active agents by using different polymers. They become a reduced irritation and improved thermal, physical, and chemical stability of the product. The present review describes microsponge technology including its method of preparation, characterization, programmable parameters and release mechanism of microsponge drug delivery system. Microsponges can be designed to programmable release of drug by using different triggers like solubility triggered systems, pressure triggered systems, temperature triggered systems and pH triggered systems.
Keywords: Microsponge delivery system (MDS), programmable release, controlled release, porous microspheres, improves bioavailability.
DOI
https://doi.org/10.22270/jddt.v9i3-s.2828Published
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