Formulation and evaluation of Emulgel containing Coriandrum sativum seeds oil for Anti-inflammatory activity
Abstract
The present work deals with the formulation and evaluation of anti-inflammatory activity containing Coriandrum sativum seeds oil. The major component of Coriandrum sativum seed oil is linalool (60-70%) and this linalool content is suitable for anti-inflammatory activity. Our main purpose is to treat inflammation at faster rate with minimum side effects. During formulation and development of any new dosage form the foremost common perplexity featured from hydrophobic behavior of medication that ultimately results in poor water solubility and bioavailability issues. Such types of problems are overcome by incorporating Coriandrum sativum seeds oil emulsion into gel base as 1:1 proportion to obtained a emulgel. Emulsion was prepared by using 32 factorial design in which peppermint oil and span 20 were selected as two factors. The emulgel was prepared by incorporating optimized batch of emulsion (F9 batch ) into gel base as 1:1 proportion and evaluated for their physical examination, pH, viscosity, extrudability, swelling index, drug content, In-vitro diffusion study, In- vivo anti-inflammatory study and stability study.
Keywords: Anti-inflammatory activity, Coriandrum sativum, Emulgel, Linalool, O/W type emulsion.
DOI
https://doi.org/10.22270/jddt.v9i3-s.2808References
Hardenia A, Jayronia S, Jain S, Emulgel: An emergent tool in topical drug delivery, International Journal of Pharmaceutical Sciences and Research, 2014; 5(5):1653-1660.
Sah S, Badola A, Nayak B, Emulgel: Magnifying the application of topical drug delivery, Indian Journal of Pharmaceutical and Biological Research, 2017; 5(1):25-33.
Khalid SA, Kumar BP, Abhinov T, Formulation and in-vitro evaluation of Aceclofenac loaded topical Emulgel, Indian Journal of Research in Pharmacy and Biotechnology, 2014; 2(6):1487-1489.
Arora R, Khan R, Ojha A, Upadhyaya K, Chopra H, Emulgel: A novel approach for hydrophobic drugs, International Journal of Pharmacy and Biological Sciences, 2017; 7(3):43-60.
Hamid KA, Ibrahim SI, Hashim MA, Salama M, Formulation and Evaluation of Benzyl Benzoate Emulgel, IOSR Journal of Pharmacy and Biological Sciences, 2015; 10(3):06-09.
Goyani M, Akbari B, Chaudhari S, Jivawala R, Formulation and evaluation of topical emulgel of antiacne agent, International Journal of Advanced Research and Review, 2018; 3(7):52-68.
Thomas J, Kuppuswamy S, Sahib AA, Benedict A, George E, A Review on Emulgel as a Current Trend in Topical Drug Delivery System, International Journal of pharmacy and pharmaceutical science, 2017; 9(3):273-281.
Pathak NL, Kasture SB, Bhatt NM, Rathod JD, Phytopharmacological Properties of Coriandrum Sativum as a Potential Medicinal Tree: An Overview, Journal of Applied Pharmaceutical Science, 2011; 1(4),20-25.
Stevens C, Talou T, Coriander oil extraction, applications and biologically active molecules. Faculty of Bioscience Engineering, 2014.
Vats A, Sharma P, Formulation and evaluation of topical antiacne formulation of coriander oil, International journal of pharmacy and pharmaceutical science research, 2012; 2(3):61-66.
Kusuma R, Formulation, Development, and Evaluation of Indomethacin Emulgel Using Pregelatinized Starch from Ipomoea batata Tubers, Asian Journal of Pharmaceutics, 2016; 9(4):S43-S50.
Patil SS, Phutane KR, Adnaik RS, Mohite SK, Magdum CS, Novel cosmeceutical herbal emulgel for skin care, World journal of pharmacy and pharmaceutical sciences, 2014; 3(4), 801-811.
Sonakpuriya P, Bhowmick M, Pandey GK, Joshi A, Dubey B, Formulation and evaluation of multiple emulsion of valsartan, International Journal of PharmTech Research, 2013; 5(1):132-146.
Patel HC, Parmar G, Seth AK, Patel JD, Patel SR, Formulation and evaluation of o/w nanoemulsion of ketoconazole, International journal of pharmaceutical sciences, 2013;4(4),338-351.
Dev A, Chodankar R, Shelke O, Emulgels: a novel topical drug delivery system, Pharmaceutical and biological evaluations, 2015; 2(4):64-75.
Kumar D, Singh J, Antil M, Kumar V, Emulgel-novel topical drug delivery system-a comprehensive review, International journal of pharmaceutical sciences and research, 2016; 7(12):4733-4742.
Khullar R, Kumar D, Seth N, Saini S, Formulation and evaluation of mefenamic acid emulgel for topical delivery, Saudi pharmaceutical journal, 2012; 20(1): 63-7.
Mohite SV, Salunkhe AK, Sudke SG, Emulgel: A novel approach for hydrophobic drugs, American journal of pharmtech research, 2019; 9(02):209:224.
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