BILAYER AND FLOATING-BIOADHESIVE TABLETS: INNOVATIVE APPROACH TO GASTRORETENSION

Authors

  • samiran dey Department of Pharmacy, Innovative College of Pharmacy, Greater Noida, Uttar Pradesh, India
  • Pranjal Kumar Singh Department of Pharmaceutics, IIMT College of Medical Sciences, Meerut, Uttar Pradesh, India

Abstract

A bilayer and floating-bioadhesive drug delivery system exhibiting a unique combination of floatation and bioadhesion to prolong residence in the stomach. Bilayer tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. Incorporation of the drug in a controlled release gastroretentive dosage forms (CR-GRDF) which can remain in the gastric region for several hours would significantly prolong the gastric residence time of drugs and improve bioavailability, reduce drug waste, and enhance the solubility of drugs that are less soluble in high pH environment. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices. The floating and bioadhesive drug delivery systems are considerably easy and logical approach. An attempt has been made in this review article to introduce the society to the current technological developments in bilayer and floating- bioadhesive drug delivery system

DOI

https://doi.org/10.22270/jddt.v1i1.26

Author Biographies

samiran dey, Department of Pharmacy, Innovative College of Pharmacy, Greater Noida, Uttar Pradesh, India

samiran dey, assistant professor, Department of Pharmacy, Innovative College of Pharmacy, Greater Noida, Uttar Pradesh, India

Pranjal Kumar Singh, Department of Pharmaceutics, IIMT College of Medical Sciences, Meerut, Uttar Pradesh, India

Department of Pharmaceutics, IIMT College of Medical Sciences, Meerut, Uttar Pradesh, India

Published

2011-10-25
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How to Cite

1.
dey samiran, Singh PK. BILAYER AND FLOATING-BIOADHESIVE TABLETS: INNOVATIVE APPROACH TO GASTRORETENSION. J. Drug Delivery Ther. [Internet]. 2011 Oct. 25 [cited 2026 Apr. 18];1(1). Available from: https://www.jddtonline.info/index.php/jddt/article/view/26

Issue

Vol. 1 No. 1 (2011): Volume 1, Issue 1, Sept-Oct 2011

Section

Review

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How to Cite

1.
dey samiran, Singh PK. BILAYER AND FLOATING-BIOADHESIVE TABLETS: INNOVATIVE APPROACH TO GASTRORETENSION. J. Drug Delivery Ther. [Internet]. 2011 Oct. 25 [cited 2026 Apr. 18];1(1). Available from: https://www.jddtonline.info/index.php/jddt/article/view/26
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