Evaluation of plasma zinc and copper in patient with chronic renal failure in Khartoum State - Sudan
Abstract
The kidney is complex vital organs, and has many functions. The main function it‘s removal of toxic and excess substancesfrom the plasma, if there is any defect in the kidney like renal failure can disrupt this function. The aim of this study was to determine the level of Zinc and Copper in Sudanese patient with chronic renal failure. This study was designed as case control, which includes 100 blood samples, a 60 from these sample were collected from patient with chronic renal failure and 40 samples were collected from health individual as control group and the sample is collected by using sterile disposable syringes and separated by centrifuge. Carried out in Ribat University Hospital in Khartoum state, during period from March to June 2018. And the plasma levels of zinc and copper determined by the use of atomic absorption spectrophotometer (OPERATOR’S MANUAL January 2003 VER 3.94 C), and the obtained results were analyzed by SPSS. The result of this study showed that there was significant decrease (p<0.05) in the plasma levels of zinc and copper in patient with chronic renal failure compared to the control subjects. The mean of plasma Zn was 0.3mg/l in test group and 0.7mg/l in control group with p. value of 0.002 and the mean of plasma Copper was 0.5mg/l in test group and 0.7mg/l in control group with p. value of 0.019. Also the study showed the gender and age of the patient, also the duration of the disease have no effect on the plasma level of zinc and copper (p 0.05). The study concludes that the plasma level of zinc and copper are low in patient with chronic renal failure. And the gender and age of the patient also the duration of disease have no significant effect on the plasma level of zinc and copper.
Keywords: Chronic Renal Failure, Zinc, Copper, Sudanese
DOI
https://doi.org/10.22270/jddt.v9i2.2434References
Frauenhoffer E, Demers LM. Beta2-microglobulin. Chicago, Ill.: ASCP Check Sample Continuing Education Program, Clinical Chemistry, 1986. [Publication no. CC 865 (CC173).]
Michael L. Bishop, Edward L.fody, LarryE. Schoeff, Clinical chemistry, 2010, chapter 12th, 557–572.
Mitchum C. Implementing the new kidney disease testing guidelines. Clin Lab News; 2002;125:411–141.
Rock RC, Walker WG, Jennings CD. Nitrogen metabolites and renal function. In: Tietz NW, ed. Fundamentals of clinical chemistry. 3rd ed. Philadelphia, Pa.: WB Saunders, 1987:669.
Solomons NW. On the assessment of zinc and copper nutriture in man. Am J ClinNutr 1979; 3(2):856-871.
U.S. Renal Data System. USRDS 2007 annual data report. Bethesda, Md.: National Institutes of Health, 2007.
Victery W, Miller R, Goyer RA: Essential trace metal excretion front rats with lead exposure and during chelation therapy. J Lab C lin Med 1986; 10:129-135.
Murugan G, evaluation of serum zinc levels in end stage renal disease patients on hemodialysis, National Journal of Basic Medical Sciences, 2007; 3(3).
Ghoreshi Z, Mosc SK Ahaley et al, effect of hemodialysis on trace elements in patients with acute and chronic renal failure, Medical Journal of the Islamic Republic of Iran, 2011; 14(4):1379
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