Floating Oral In-Situ Gel: A Review

Authors

  • Rabiah Bashir Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.
  • Asmat Majeed Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.
  • Tabasum Ali Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.
  • Saeema Farooq Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.
  • Nisar Ahmad Khan Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.

Abstract

The drugs having a narrow absorption window in the gastrointestinal tract (GIT) when administered by oral route are often limited by poor bioavailability due to incomplete drug release and short residence time at the site of absorption. Novel drug delivery systems in the form of gastroretentive systems such as floating systems, mucoadhesive, high-density, expandable have been developed as they provide controlled delivery of drugs with prolonged gastric residence time. Liquid orals are more prone to low bioavailability because they are eliminated quickly from the stomach since they are subjected to faster transit from the stomach/ duodenum. The problems of immediate release and short gastrointestinal residence of liquids are eliminated by formulating as oral in situ gels as they provide the best means to overcome these problems The in situ gel dosage form is a liquid before administration and after it comes in contact with gastric contents due to one or more mechanisms gets converted to gel which floats on gastric contents. This achieves increased residence as well as sustained release. This approach is useful for systemic as well as local effect of drugs administered. This review gives a brief idea about floating oral in-situ gel formation and research done by various scientists on a number of drugs and polymers.

Keywords: Floating drug delivery, gastric retention time, In-situ gel.

DOI

https://doi.org/10.22270/jddt.v9i2.2372

Author Biographies

Rabiah Bashir, Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.

Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.

Asmat Majeed, Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.

Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.

Tabasum Ali, Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.

Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.

Saeema Farooq, Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.

Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.

Nisar Ahmad Khan, Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.

Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.

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Published

2019-03-15
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How to Cite

1.
Bashir R, Majeed A, Ali T, Farooq S, Khan NA. Floating Oral In-Situ Gel: A Review. J. Drug Delivery Ther. [Internet]. 2019 Mar. 15 [cited 2026 Feb. 1];9(2):442-8. Available from: https://www.jddtonline.info/index.php/jddt/article/view/2372

Issue

Vol. 9 No. 2 (2019): Volume 9, Issue 2 March-April 2019

Section

Review

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How to Cite

1.
Bashir R, Majeed A, Ali T, Farooq S, Khan NA. Floating Oral In-Situ Gel: A Review. J. Drug Delivery Ther. [Internet]. 2019 Mar. 15 [cited 2026 Feb. 1];9(2):442-8. Available from: https://www.jddtonline.info/index.php/jddt/article/view/2372
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