Spectrophotometric analysis of tablets of nalidixic acid using melted niacinamide as solvent
In the current attempt of research, novel method for spectrophotometric estimation of nalidixic acid in tablets using melted niacinamide as solvent was developed. The main objective behind research is to show “SOLIDS ALSO POSSESS SOLUBILIZING POWER”. The current study deals with novel spectrophotometric analytical technique for quantitative estimation of nalidixic acid in tablets using melted niacinamide as solvent. According to the theory proposed by Maheshwari, each & every substance possesses solubilising power; substance may be a gas, solid or liquid. Niacinamide imbibes large solubilizing power to nalidixic acid and having approximate solubility more than 80 mg per gm of melted niacinamide (135°C) whereas aqueous solubility of nalidixic acid is 0.21mg/ml at room temperature. Calibration curve of nalidixic acid was plotted by recording the absorbances of standard solutions of drug. The absorbances were observed at 330 nm against respective reagent blanks. The percentage label claims were found very close to 100 (100.93± 1.303 and 99.08±1.764) indicating accuracy of the proposed method. Percentage recoveries estimated by the proposed method are close to 100 (99.91±1.303 and 101.74±1.663) with significant low values of percentage deviation and standard error. Thus, it may be concluded that proposed method is simple, safe and precise and excludes use of toxic organic solvents.
Keywords: Mixed Solvency, Solubilizing Power, Spectrophotometric Analysis, Niacinamide, Nalidixic Acid.
2. Maheshwari RK. Solubilization of ibuprofen by mixed solvency approach. The Indian Pharmacist 2009; 8(87):81-84.
3. Maheshwari RK. “Mixed- solvency” – A novel concept for solubilization of poorly water-soluble drugs. Delving J. Tech. Eng. Sci. 2009; 1(1):39-43.
4. Rajesh Kumar Maheshwari, “Solid as solvent”, Novel spectrophotometric analysis of satranidazole tablets using phenol as solvent. The Indian Pharmacist 2014; XII: 37-40.
5. Maheshwari RK. Potentiation of solvent character by mixed solvency concept: A novel concept of solubilization. Journal of Pharmacy Research 2010; 3(2):411-413.
6. Maheshwari RK, Shilpkar R. Formulation development and evaluation of injection of poorly soluble drug using mixed solvency concept. International Journal of Pharma and Biosciences 2012; 3(I):179-189.
7. Maheshwari RK, Upadhyay N, Jain J, Patani M, Mathuria KC. New spectrophotometric estimation of naproxen tablet formulation employing mixed solvency concept (at 331 nm). International Journal of Pharmacy and Technology 2011; 3(4):3618-3623.
8. Soni LK, Solanki SS, Maheshwari RK. Solubilization of poorly water soluble drug using mixed solvency approach for aqueous injection. British Journal of Pharmaceutical Research 2014; 4(5):549-568
9. Maheshwari Y, Mishra DK, Mahajan SC, Maheshwari P, Maheshwari RK, Jain J. Novel pharmaceutical application of mixed solvency in the formulation development of syrups (liquid oral solutions) of poorly water-soluble drugs. International Journal of Pharmacy 2013; 3(4):753-758.
10. Maheshwari RK, Rajagopalan R. Formulation and evaluation of tinidazole syrup made by mixed-solvency concept. Der Pharmacia Lettre 2011; 3(6):266-271.
11. Bhawsar N, Maheshwari RK, Ansari A, Saktawat Y. New spectrophotometric estimation of gatifloxacin in the tablets using mixed solvency approach. International Journal of Pharmaceutical Science 2011; 2(2):270-274.
12. Maheshwari RK, Karawande VU, Application of novel concept of mixed solvency in the design and development of floating microspheres of furosemide. International journal of Pharmacy and Pharmaceutical Sciences 2013; 15:167-195.
13. Maheshwari RK, Upadhyay N, Jain J, Patani M, Pandey R. New spectrophotometric analysis of gatifloxacin tablets utilizing mixed solvency concept (at 288 nm). Der Pharmacia Lettre 2012; 4(1):1-4.
14. Agrawal A, Maheshwari RK. Formulation development and evaluation of in situ nasal gel of poorly water soluble drug using mixed solvency concept. Asian Journal of Pharmaceutics 2011; 5(3):131-140.
15. Sreegiriprasad B, Gupta VRM, Devanna N, Ramadevi M, Vishnuvarethan rao G. Mixed Solvency Concept: A promising tool to enhance solubility of poorly soluble drug aceclofenac. International Journal of Pharmaceutical Chemical and Biological Sciences 2012; 3:338-342.
16. Chandna C, Maheshwari RK. Mixed solvency concept in reducing surfactant concentration of self emulsifying drug delivery systems of candesartan cilexetil using D-optimal mixture design. Asian Journal of Pharmaceutics 2013; April-June: 83-91.
17. Vijayranga G, Deveswaran R, Bharath S, Basavraj BV, Madhavan V. Development of an analytical method for spectrophotometric estimation of ketoprofen using mixed solvency approach. International Journal of Pharmaceutical Sciences and Research 2012; 4:1053-1056.
18. Prashant B, Rawat S, Mahajan YY, Galgatte UC, Maheshwari RK. Formulation development and evaluation of aqueous injection of poorly soluble drug made by novel application of mixed solvency concept. International Journal of Drug Delivery 2013; 2:152-166.
19. Maheshwari RK, Gupta S, Gharia A, Garg SK, Shilpkar R. Simple eco-friendly spectrophotometric estimation of tinidazole tablets by application of mixed-solvency technique. Bulletin of Pharmaceutical Research 2011; 1(1):22-25.
20. Maheshwari RK, Rajagopalan R. Formulation and evaluation of paracetamol syrup made by mixed-solvency concept. Der Pharmacia Lettre 2012; 4(1):170-174.
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