A REVIEW ON FAST DISSOLVING TABLETAntidiabetic and anticataract evaluation of different extracts of Butea monosperma Linn. in STZ induced diabetic animals
Abstract
Aim- The main aim of study is to evaluate the anti-diabetic and anti-cataract activity of different extracts of Butea monosperma in diabetic animals. Material & Methods- Different extracts were prepared by successive solvent extraction methods. All the extracts were examined for the presence of different phytoconstituents. Diabetes was induced by single injection of STZ (40mg/kg) in Wistar albino rats and diabetes was confirmed by measurement of blood glucose level with the help of glucometer which is based on glucose oxidation methods. For the anti-cataract activity cataract was induced by solution of glucose in goat lenses and different biochemical parameters i.e. MDA, Na+, K+ were measured. Results- Preliminary phytochemical screening methods showed the presence of alkaloids, flavonoids, terpenoids, glycosides etc. In anti-diabetic evaluation, butanolic extract showed a highly significant activity in diabetic animals as compared to other extracts. So butanolic extract was further selected for the anti-cataract activity in goat eye lenses. Butanolic extract also highly significantly affect cataract formation all related biochemical parameters and electrolyte level. Conclusion- Administrations of butanolic extract have significant antidiabetic effect in STZ induced diabetes. Butanolic extract exhibited potent anti-hyperglycemic, antioxidant and anti-cataract effects in STZ induced type 2 diabetic rats. This effect may be presence of flavonoids in butanolic extract.
Keywords: Cataract, STZ induced diabetes, Butea monosperma, Butanolic extract, Hyperglycemia
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