Antioxidants: a brief review
Abstract
The field of free radical chemistry has gained a great deal of attention in recent years. Free radicals reactive oxygen species generated by our body by various endogenous systems leads to various pathological conditions. A balance between free radicals and antioxidants is prerequisite for proper physiological function. Oxidative stress caused by generation of free radicals adversely alters lipids, proteins, and DNA and provokes a number of human ailments. Oxidative stress can be managed by using external sources of antioxidants. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be harmful for human health. Thus, the search for effective, nontoxic natural compounds with antioxidant activity has been escalated in recent years. The present review provides a brief overview on antioxidants and natural sources of antioxidants in the management of human diseases.
Keywords: free radical, Oxidative stress, antioxidants,
DOI
https://doi.org/10.22270/jddt.v8i6-s.2116References
Percival M. Clinical nutrition insights. Advanced nutrition publications, Inc., Revised, 1998:1-4.
Meena H, Pandey HK, Pandey P, Arya MC, Ahmed Z. Evaluation of antioxidant activity of two important memory enhancing medicinal plants Baccopa monnieri and Centella asiatica. Indian Journal of Pharmacology, 2012; 44(1):114–117.
Premathilaka R, Wickramasinghe I, Hewage S. In vitro antioxidant activity of leaf extracts in three medicinal plants; Costus specious (Koen.) Smith, Coccinia grandis (L.) J. Voigt and Wattakaka Volubilis. European Journal of Academic Essays, 2016; 3(3):141-146.
Bras ML, Clément MV, Pervaiz S, Brenner C. Reactive oxygen species and the mitochondrial signaling pathway of cell death. Histology and Histopathology, 2005; 20:205-220.
Aprioku JS. Pharmacology of Free Radicals and the Impact of Reactive Oxygen Species on the Testis. The Journal of Reproduction and Infertility, 2013; 14(4):158–172.
Sies H., Antioxidants in Disease, Mechanisms and Therapy. Academic Press, New York; 1996.
Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. Oxford University Press, Oxford; 1997.
Lu J, Zheng YL, Wu DM, Sun DX, Shan Q. Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Biochemistry and Pharmacology, 2007; 74(7):1078-1090.
Gupta R, Sharma M, Reddy KS. Improved method of total antioxidant assay. Indian Journal of Biochemistry and Biophysics, 2009; 46:126-129.
Sies H. Oxidative stress: oxidants and antioxidants. Experimental Physiology, 1997; 82(2):291-5.
Jeeva JS, Sunitha J, Ananthalakshmi R, Rajkumari S, Ramesh M, Krishnan R. Enzymatic antioxidants and its role in oral diseases. The Journal of Pharmacy and Bioallied Sciences, 2015; 7:S331-3.
McCord JM, Fridovich I. Superoxide dismutase: an enzymatic function for erythrocuprein (hemocuprein). The Journal of biological chemistry, 1969; 244:6049–6055.
Fridovich I. Superoxide radical and superoxide dismutases. Annual Review of Biochemistry, 1995; 64:97–112.
Teixeira HD, Schumacher RI, Meneghini R. Lower intracellular hydrogen peroxide levels in cells over-expressing Cu-Zn superoxide dismutase. Proceedings of the National Academy of Sciences, 1998; 95:7872–5.
Sandalio LM, Lo ́pez-Huertas E and Bueno P. Immunocytochemical localization of copper, zinc superoxide dismutase in peroxisomes from watermelon (Citrullus vulgaris Schrad.) cotyledons. Free Radical Research, 1997; 26:187–94.
Nordberg J, Elias S, Arner J. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radical Biology and Medicine, 2001; 31(11):1287–1312.
Krishnamurthy P, Wadhwani A, 2012. Antioxidant enzymes and human health. http://dx.doi.org/10.5772/48109 accessed on 7/9/2013.
Molan AL, Faraj AM, Mahd AS. Antioxidant activity and phenolic content of some medicinal plants traditionally used in Northern Iraq. Phytopharmacology, 2012; 2(2):224-233.
Ali SS, Kasoju N, Luthra A, Singh A, Sharanabasava H, Sahu A, Bora U,. Indian medicinal herbs as sources of antioxidants. Food Research International, 2008; 41(1):1–15.
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