Formulation and evaluation of oxymetazoline hydrochloride nasal gels
Abstract
The main intend of the implement sniff out formulate and evaluate oxymetazoline nasal gels. To achieve more persistent blood levels with decrease dosage of medicine by extended drug evidence and by passing hepatic initially cross metabolism and body including inferable disgrace. Mod FTIR & DSC spectra there is not any discrepancein the seam clean medicine, polymers & lipids. The Carbopol consisting of reinforce precail eventual scintillating moreover transparent Poloxamer, Hydroxy Propyl Methyl cellulose gels crop up prospective lucent as a consequence frosted slimy. The pH value of all developed formulations of gels (ONGF1-ONGF8) was in the range of 6.2 to 6.9. Spreadability of gels was in the range 19.51 - 33.91 g.cm/sec, The Viscosity of various formulated gels was found in range of 8628 to 9622 centipoises. The percentage drug content of all prepared gel formulations were found to be in the range of 78.53 to 98.56 %. The gel strength of all prepared formulations of gels was found to be in the range of 69 to 96 %. In-vitro diffusion drug release of Oxymetazoline Hydrochloride of nasal gels ONGF1 shows the 95% drug release. The release order kinetics shows all the formulations ONGF1 to ONGF8 formulations were followed Korsemeyer-Peppas with correlation coefficient R2=0.8969 & 0.2692 respectively. ONGF1 formulation follows both Zero order and Korsmeyer-Peppas models, it indicates diffusion release mechanism followed by non-fickian transport.
Keywords: Nasal, gels, Oxymetazoline, In vitro diffusion, Carbopol.
DOI
https://doi.org/10.22270/jddt.v8i6.2007References
F Glazener, K Blake, and M Gradman Bradycardia, hypotension, and near-syncope associated with afrin (oxymetazoline) nasal spray. N Engl J Med, 1983; 309(12):731-739
Thrush DN. Cardiac arrest after oxymetazoline nasal spray. J Clin Anesth, 1995; 7:512-514.
Yerikala Ramesh, Kavya Teja P, Karuna Santhi K, Saraswathi H, Neeharika P, Saideepthi B, Formulation and evaluation of Losartan loaded Proliposomal gels, International Journal of Pharmacometrics and Integrated Biosciences, 2017; 2(4):173-178.
S Gizurason. The relevance of nasal physiology to the design of drug absorption studies. Adv. Drug Deliv. Rev, 1993; 11:329-347.
LL Ning. Characteristics of ophthalmic in situ gel and issues in progress. Chin. J. New Drugs, 2007; 16:988-990.
Saudagar, Formulation Development and Evaluation of Topical Gel of Lisinopril Dihydrate Scholars Academic Journal of Pharmacy, 2016; 5(7):277-283.
Yerikala Ramesh, Jayachandra Reddy Peddappi Reddigari, Chandrasekhar B. Kothapali, ‘Formulation and Evaluation of Tropicamide In-situ gels Loaded Solid Lipid Nanoparticles for Ocular Drug Delivery,’ Journal of Drug Delivery and Therapeutics, 2018; 8(2):194-207.
Kanahaiya. Agrawal, In-Situ Gel Formation for topical Drug Delivery System, Asian Journal of Biomedical and Pharmaceutical Sciences, 2011; 1 (4):01-07.
Kavitha D, Formulation and evaluation of intra Topical gel of Levofloxacin, European journal of pharmaceutical and medical research, 2017; 4(12):249-253.
PatilSonali K, Formulation and Evaluation of Topical Gel for Alzheimer Disease International Research Journal of Pharmaceutical and Biosciences, 2015; 2(2):41- 58.
Sheri Peedikayil sherafudeen, Development and evaluation of Topical gel formulations of loratadine, research in pharmaceutical sciences, 2015; 10(6):466-476.
Jyotsana Madan and Ramnik Singh, Formulation and evaluation of in-situ muco -adhesive Topical gel of Montelukast sodium, Der Pharmacia Sinica, 2014; 5(2):1-8.
Arvind N, Formulation and evaluation of Topical gel of Phenylephrine hydrochloride, International Journal of Drug Research and Technology 2016; 6 (2):64-78.
Mothukuri Tejaswini and A. Seetha Devi, Formulation and evaluation of nasal in situ gel of Phenylephrine hydrochloride, International Journal of Drug Research and Technology 2016; 6 (2):64-78.
Jaya Raja Kumar, optimization and characterization of oxymetazoline based thermosensitive in situ gel for nasal drug delivery by using stat-ease design-expert software, Rapports De Pharmacie, 2016; 2 (2):251-264
M.D. God bole, Priti W. There, P.V. Dangre, Formulation and optimization of prolonged release nasal in situ gel for treatment of migraine, Indo American Journal of Pharmaceutical Research, 2014; 1(3):45-48
Ashok K. Rajpoot, Hitesh Kumar, Neelam Jain, Harish C. Verma, Formulation and Evaluation of Mucoadhesive Nasal in-situ Gel of Diclofenac Sodium, MIT International Journal of Pharmaceutical Sciences, 2015; 1(2):21-55.
Kailas K Mali, Shashikant C Dhawale, Remeth J Dias, Vijay D Havaldar, Vishwajeet S Ghorpade, Nitin H Salunkhe, Nasal Mucoadhesive In-Situ Gel of Granisetron Hydrochloride using Natural Polymers, Journal of Applied Pharmaceutical Science, 2015; 5 (07):084-093.
Swapnil D., Sonawane, SwaroopLahoti, Design and Evaluation of Ion Induced in Situ Gel formulation For Levofloxacin Hemihydrates ocular Delivery, International Journal of Pharmaceutical Science Invention, 2014; 3 (11):38-43.
Varsha Gaikwad, Formulation and evaluation of In-Situ gel of metoprolol tartrate for nasal delivery, Journal of Pharmacy Research, 2010; 3(4):788-793.
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