PREPARATION AND EVALUATION OF MODIFIED TAMARIND SEED GUM AS A NOVEL SUPERDISINTEGRANT
Abstract
The aim of present study was to preparation and evaluation of modified Tamarind seed as natural superdisintegrant. The extracted gum from the Tamarind seed was modified chemically by carboxymethylation of extracted gum was done to improve the hydrophilic nature of the gum. Futher, carboxymethylated gum was complexed by using calcium chloride to enhances the wetting capacity of the gum. The modification in functional group of extracted gum, carboxymethyled gum, Calcium complexed gum was studied by FT-IR spectrophotometer. The DSC studies shows that the changes in melting point of the carboxymethyled gum and the calcium complexed gum as compared to the extracted gum without undergoing chemical modification. The modified gum was then subjected to different studies like color, pH of gum solution, swelling indexetc. The dummy tablet prepared with calcium complexed modified Tamarind seed gum to check its disintegration effect of the tablet. The various pre-compression parameters of the tablet blend was determined like bulk density, tapped density, Carr's index, angle of repose and Hausner's ratio. The disintegration time of these dummy tablet carry the calcium complexed tamarind seed gum was compared to formulate tablet with marketed superdisintegrant i.e. sodium starch glycolate . The disintegration time of calcium complexed Tamarind seed gum was observed to be 1 min. approx. 32.5 sec. -35.2 sec. showing good disintegrating property. It can be concluded that Fast disintegrating tablet using modified Tamarind seed gum as natural superdisintegrant improves the disintegration time of the tablet.
Keywords: FDT tablet, Tamarind seed gum, Sodium starch glycolate, Swelling time.
DOI
https://doi.org/10.22270/jddt.v8i5-s.1994References
Amaliyar P R, Patel H, Chaudhary S A, Shah H, Patel A. A brief review on natural and synthetic superdisintegrant. Inventi journal. 2014; 3 :1-6
Shihora H, Panda S. Superdisintegrants, utility in dosage form : A quick review. JPSBR. 2011; 3(1): 148-153.
Shrivastava P, Sethi V. A review article on : Superdisintegrants. International Journal of Drug Research and Technology. 2013; 3(4): 76-87.
Gohel M C, Parikh R K, Brahmbhatt B K, Shah A R. Prepartion and Assesement of Novel Co-processed Superdisintegrant consisting of crosspovidone and sodium starch glycolate: A Technical Note. AAPS Pharm Sci Tech. 2007; 8(1): 1-6.
Lopez-solis L, Villafurerte-Robles L. Effect of Disintegrants with different hygroscopicity on dissolution of Norfloxacin/ Pharmatose DCL 11 tablets. International Journal of Pharmaceutics. 2001; 127-135.
Rawat S, Derle D V, Sulbha R F, Shinde P R, Parve B S. Superdisintegrants: An overview. World Journal of Pharmacy and Pharmaceutical Sciences. 2014; 3(5): 263-278.
Mohanchandran P S, Sindhumol P G, T S Kiran. Superdisintegrants: An Overview. International Journal of Pharmaceuitcal Science Review and Research. 2011; 6(1): 145-152.
Mukesh C G, K P Rajesh, K B Bansari, R S Aarohi. Prepartion and Assessement of Novel Co-processed Superdisintegrant consisting of crosspovidone and sodium starch glycolate. AAPS Pharm Sci Tech. 2007; 8: 1-7.
H A Mohamed, B E Mohamed, K E Ahmed. Physicochemical Properties of Tamarind (Tamarindus indica) Seed polysacchride. Journal of Food Procesing and Technology. 2015; 6(6): 1-5.
Bhusari SN, Muzaffar K, Kumar . Effect of Carrier agents on Physical and Microstructral Properties of Spray dried Tamarind pulp powder technology. 2014; 266: 354-364.
Surati B I, Minocheherhomji F P. Benefits of Tamarind Kernal Powder- A natural Polymer. IJAR, 2018; :54-57.
Singh R, Malviya R, Sharma P K. Extraction and Characterization of Tamarind seed Polysaccharides as a polysaccharide excipient. Pharmacognosy Journal. 2011; 3(20): 17-19.
Mali K K, Dhawale S C. Design and optimization of Modified Tamarind Gum-Based Floating Bioadhesive tablets of Verapamil Hydrochloride. Asian Journal of Pharmaceutics. 2016; 10(4): 239.
Ahuja M, Singh S, Kumar A. Evaluation of Carboxymethyl gellan gum as a mucoadhesive polymer. Internatinal Journal of Biological Macromolecules. 2013; 53: 114-121.
Rai P R, Tiwari A K, Rana V. Superior disintegrating properties of calcium cross linked cassia fistula gum derivative for fast dissolving tablet. Carbohydrate polymers. 2012: 1098-1104.
Ponikornkit B, Ngamsalak C, Hunbutta K, Sittikijyothin W. Swelling behaviour of Carboxymethylated Tamarind gum. Advanced Material Research. 2014; 1060; 137-140.
Immadi H P, Kala S L J, Rao K S, Manikiran S S, Rao N R. IJPPR. 2017; 10(2): 121-138.
Pawha R, Gupta N. Superdisintegrant in the development of orally disintegrating tablets: A Review. IJPSR. 2011; 2(11): 2767-2780.
Published
Abstract Display: 727 
PDF Downloads: 883 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.