IN-VITRO AND IN VIVO STUDIES OF CETUXIMAB LOADED POLYMERIC NANOPARTICLES
Abstract
Nanoparticles speak to one of the appealing choices in the compelling treatment of tumor chemo-treatment. In the present work, definition and improvement of a novel Cetuximab (MTX)- stacked biodegradable nanoparticles utilizing poly(D,L-lactide-co-glycolide) (PLGA) was done. The arranged nanoparticles were assessed for physicochemical properties, for example, molecule measure, zeta potential, discharge thinks about, and so forth. Molecule size of upgraded definition was < 200 nm. Our essential outcomes exhibit that the created Cetuximab-stacked PLGA nanoparticles discharging the medication for delayed timeframe.
Keywords: Cetuximab; PLGA 50:50; nanoparticles
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References
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2. Babbar A., Kashyap R., Chauhan U.P. A convenient method for the preparation of 99mTc-labelled pentavalent DMSA and its evaluation as a tumour imaging agent. J. Nucl. Biol. Med. 1991; 35:100-104.
3. Bhatnagar A., Singh A.K., Babbar A., Soni N.L., Singh T. Renal imaging with 99Tc (m)-dextran. Nucl. Med. Commun. 1997; 18:562-566.
4. Blok D., Feitsma R.I., Wasser M.N., Nieuwenhuizen, W., Pauwels E.K., 1989. A new
5. method for protein labeling with 99mTc. Int. J. Rad. Appl. Instrum. B. 16, 11-16.
6. Chervu L.R., Blaufox M.D. Renal radiopharmaceuticals-an update. Semin. Nucl.Med. 1982; 12:224-245.
7. Florence A.T. The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual. Pharm. Res. 1997; 14:259-266.
8. Garron J.Y., Moinereau M., Pasqualini R., Saccavini J.C. Direct 99mTc labeling of monoclonal antibodies: radiolabeling and in vitro stability. Int. J. Rad. Appl. Instrum. B. 1991; 18:695-703.
9. Hillery A.M., Jani P.U., Florence A.T. Comparative quantitative study of lymphoid and non lymphoid uptake of 50 nm polystyrene particles. J. Drug. Target. 1994; 2:151-154.
10. Jani P., Halbert G.W., Langridge J., Florence, A.T. The uptake and translocation of the latex nanospheres and microspheres after oral administration to rats. J. Pharm. Pharmacol. 1989; 41:809-812.
11. Jani P., Halbert G.W., Langridge J., Florence, A.T. nanoparticle uptake by the rat gastrointestinal mucosa: Quantification and particle size dependency. J. Pharm. Pharmacol. 1990; 42:821-826.
12. Jani P.U., Florence A.T., McCarthy D.E., Further histological evidence of the gastrointestinal absorption of polystyrene nanospheres in the rat. Int. J. Pharm. 1992; 84:245-252.
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Kaushik A, Sharma HK. IN-VITRO AND IN VIVO STUDIES OF CETUXIMAB LOADED POLYMERIC NANOPARTICLES. JDDT [Internet]. 15Oct.2018 [cited 3May2024];8(5-s):184-8. Available from: https://www.jddtonline.info/index.php/jddt/article/view/1941
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