IN SILICO HOMOLOGY MODELING AND VALIDATION OF Α-GLUCOSIDASE ENZYME

Authors

  • Navin Sainy School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP)-452017, India
  • Nidhi Dubey School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP)-452017, India

Abstract

In this research work we have derived three dimensional (3D) structure of α-glucosidase enzyme through homology modeling and the predicted structure was validated with the help of PROCHECK analysis in the form of Ramachandran plot. According to Ramachandran plot statistics the derived model was found to be of good quality. 

DOI

https://doi.org/10.22270/jddt.v7i7.1609

Author Biographies

Navin Sainy, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP)-452017, India

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP)-452017, India

Nidhi Dubey, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP)-452017, India

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP)-452017, India

References

Temelkova-Kurktschiev T, Koehler C, Henkel E, Leonhardt W, Fuecker K, Hanefeld M, Postchallenge Plasma Glucose and Glycemic Spikes Are More Strongly Associated With Atherosclerosis Than Fasting Glucose or HbA1c Level, Diabetes Care, 2000, 23, 1830-1834.

Bastyr E J, Stuart, C A, Brodows, Therapy focused on lowering postprandial glucose, not fasting glucose, may be superior for lowering HbA1c. IOEZ Study Group, RG Diabetes Care, 2000, 23, 1236-1241.

Fiser A, Sali A, Modeller: generation and refinement of homology-based protein structure models, Meth Enzym, 2003, 374, 461- 491.

Moche M, Dehesh K, Edwards P, Lindqvist Y, The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54 A resolution and its relationship to other condensing enzymes, J Mol Biol, 2001, 305, 491-503.

Published

2017-12-22
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How to Cite

1.
Sainy N, Dubey N. IN SILICO HOMOLOGY MODELING AND VALIDATION OF Α-GLUCOSIDASE ENZYME. J. Drug Delivery Ther. [Internet]. 2017 Dec. 22 [cited 2026 Jan. 17];7(7):126-7. Available from: https://www.jddtonline.info/index.php/jddt/article/view/1609

How to Cite

1.
Sainy N, Dubey N. IN SILICO HOMOLOGY MODELING AND VALIDATION OF Α-GLUCOSIDASE ENZYME. J. Drug Delivery Ther. [Internet]. 2017 Dec. 22 [cited 2026 Jan. 17];7(7):126-7. Available from: https://www.jddtonline.info/index.php/jddt/article/view/1609