SOLUBILITY ENHANCEMENT OF EFAVIRENZ (BCS CLASS II DRUG) BY CYCLODEXTRIN INCLUSION COMPLEX TECHNIQUE
Abstract
The solubility of BCS class II drugs can be enhanced using inclusion complex techniques. Cyclodextrin (CD) and its derivatives are promising carrier for the enhancement of aqueous solubility of drugs. The use of the Kneading technique to obtain solid inclusion system permitted the formation of a uniform, substantially non-crystalline particle, which increased the solubility and stability of Efavirenz (EFV). The present work shows the enhancement of aqueous solubility of BCS class II drug i.e. EFV by making inclusion complex with β-CD. The aqueous solubility of EFV is calculated to be 5± 0.003 µg/ml which was increased up to 288.9±0.005 µg/ml when complexed with β-CD in ratio of 1:1 and 318.5± 0.03 µg/ml in ratio of 1:2. This shows that, the inclusion complex technique is a promising way to enhance aqueous solubility.
DOI
https://doi.org/10.22270/jddt.v7i7.1581References
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