DESIGN AND EVALUATION OF COLON TARGETED DELIVERY OF TEGASEROD MALEATE FOR IRRITABLE BOWEL SYNDROME
Abstract
The colon is being extensively investigated as a drug delivery site. Colonic drug delivery is a relatively recent approach for the treatment of diseases like ulcerative colitis, Crohn’s disease, and irritable bowel syndrome. To achieve successful colon targeted drug delivery, a drug needs to be protected from degradation, release and /or absorption in upper portion of GI tract and then ensure abrupt or controlled release in proximal colon. The purpose of this research is to develop and evaluate the polysaccharide based compression coated tablets of Tegaserod maleate for the treatment of irritable bowel syndrome. Core tablets of Tegaserod maleate were compression coated with various proportions of Galactosol, xanthan gum and chitosan. This work aimed to prepare compression coated tablets by direct compression method using single polymer and combination of polymers. And to evaluate prepared tablets parameters like hardness, friability, thickness, diameter, weight variation, drug content, swelling index, in vitro drug release.
Keywords: Colon, Tegaserod maleate, Galactosol, xanthan gum and chitosan
Â
DOI
https://doi.org/10.22270/jddt.v8i2.1563References
Krishnainah YSR. Satyanarayana S. Colon specific drug delivery systems. Ir: Jain NK. Advances in controlled and novel drug delivery. New Delhi, India: CBS Publishers and Distributors; 89-120.
Saraf A, Dubey N. Diallyldisulfide containing polymeric nanoparticles for site-specific delivery in colon cancer. Journal of Drug Delivery and Therapeutics, 2017; 7(7):50-51. doi:10.22270/jddt.v7i7.1584
Jain A, Gupta Y, Jain SK. Perspective of Biodegradable natural polysaccharides for site specific drug delivery to the colon. J.Pharm Pharmaceut sci.2007; 10(1):86-128.
Fell JT. Targeting of drug and delivery system to specific sites in the gastrointestinal tract .J.Anat 1996; 189:517-519.
Zhang SQ, Thumma S, Chen GH, Deng WB, Repka MA, Li SM, “ In vitro and in vivo evaluation of tegaserod maleate pH-dependent tabletsâ€, Eur J Pharm Biopharm. 2008 May; 69(1):247-54.
Venkatesh DN, Reddy AK, Samanta MK, Suresh B , “ Development and in vitro evaluation of colonic drug delivery systems for tegaserod maleateâ€, Asian J Pharm. 2009 [cited 2011 Feb 20]; 3:50-3.
Agarwal D, Ranawat M, Chauhan C, Kamble R. Formulation and charecterisation of colon targeted pH dependent microspheres of capecitabine for colorectal cancer. Journal of Drug Delivery and Therapeutics, 2014; 3(6):215-222. doi:10.22270/jddt.v3i6.747
Nunthanid J, Luangtana-anan M, Sriamornsak P, Limmatvapirat S, Huanbutta K, Puttipipatkhachorn S. Use of spray-dried chitosan acetate and ethylcellulose as compression coats for colonic drug delivery: Effect of swelling on triggering in vitro drug release. Eur J Pharm Biopharm 2009; 71:356-61.
Patel Nirav V, Patel Jayvadan K, Shah Shreeraj H, Patel Jagruti J. Design, development and in vitro evaluation of Mesalamine tablets containing Pectin and Chitosan for colon-specific drug delivery. Int J Res Pharm Sci 2010; 1(2):94-102.
Ravi V, Pramod Kumar M, Siddaramaiah. Novel colon targeted drug delivery system using natural polymers. Indian J Pharm Sci 2008; 70:11-113.
Naikwade Sonali R, Kulkarni Prathibha P, Jathar Shripad R, Bajaj Amrita N. Development of time dependent controlled release colon specific delivery of tinidazole. Res J Pharm Bio Chem Sci 2008.
Ugurlu T, Turkogiu M, Soyogul Gurer U, Akarsu B. Colonic delivery of compression coated nisin tablets using pectin/HPMC polymer mixture. Eur J Pharm Biopharm 2007; 67:202-10.
Krishnaiah YSR, Satyanarayana V, Kumar BD, Karthikeyan RS. In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5- fluorouracil. Eur J Pharm Biopharm 2002; 16:185-92.
Krishna K, Nandgude T, Bhise K, Deshmukh P. Studies on development of oral colon targeted drug delivery system of locust bean and Xanthan gums. Int J Gr Pharm 2007; 1:33-36.
Krishna K, Nandgude T, Bhise K, Deshmukh P. Studies on development of oral colon targeted drug delivery system of locust bean and Xanthan gums. Int J Gr Pharm 2007; 1:33-36.
Published
Abstract Display: 1309 
PDF Downloads: 940 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.