ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF AERIAL ROOT OF FICUS RELIGIOSA IN ANIMAL MODELS
Abstract
Ficus religiosa commonly found tree in Indian sub-continent has numerous neuro-pharmacological effects including epilepsy in traditional medicine. Therefore, anticonvulsant effect of aqueous aerial root extract of F. religiosa at oral doses 25, 50 and 100 mg/kg was studied using Maximum electroshock (MES) and Pentylenetetrazole (PTZ) induced seizure models in mice. F. religiosa showed anticonvulsant effect dose dependently in MES & PTZ test. In MES model F. religiosa 100mg/kg significantly (p < 0.05) lowered duration of Tonic hind limb extension. In PTZ model, all three doses of F. religiosa significantly (p < 0.05)  increased latency to convulsion. These findings thus provide scientific evidence in support of the folkloric use of this plant in the management of epilepsy.
Keywords: Anticonvulsant, Ficus religiosa, Maximum electroshock, Pentylenetetrazole, Root
DOI
https://doi.org/10.22270/jddt.v8i1.1543References
Anovadiya AP, Jayesh JS, Vadgama VK & Tripathi CB, Evaluation of antiepileptic and memory retention activity of curcumin per se and incombination with antiepileptic drugs, Asian J Pharm Clin Res, 2013; 6(2):145.
Keshavarz M, Showraki A & Emamghoreishi M, Anticonvulsant Effect of Guaifenesin against Pentylenetetrazol-Induced Seizure in Mice, Iran J Med Sci, 2013; 38(2):116.
Dhar U, Manjkhola S, Joshi M, Bhatta A et al, Current status and future strategy for development of medicinal plant sector in Uttranchal, India, Curr Sci, 2002; 83(8):956–964.
Panchawat S. Ficus religiosa Roxb. (Peepal): A Phyto-Pharmacological Review, IJPS, 2012; 1(1):435-446.
Kaur A, Rana AC, Tiwari V, Sharma R and Kumar K, Review on Ethnomedicinal and Pharmacological Properties of Ficus religiosa, JAPS, 2011; 01(08):06-11.
Sreelekshmi R, Latha PG, Arafat MM, Shyamal S et al, Anti- inflammatory, Analgesic and Anti-lipid peroxidation studies on stem bark of Ficus religiosa Linn, Nat Prod Radian, 2007; 6(5):377-381.
Kirana H, Agrawal SS & Srinivasan BP, Aqueous extract of Ficus religiosa Linn. Reduced oxidative stress in experimentally induced type 2 diabetic rats, Ind J Exp Biol, 2009; 47:822-826.
Khan SA, Hussain SA, Jais AM, Zakaria Z & Khan M, Anti-ulcer activity of Ficus religiosa stem bark ethanolic extract in rats, J Med Plants Res, 2011; 5(3);354–359.
Kaur D, Singh B and Goel RK, Antiamnesic effect of Ficus religiosa in scopolamine induced anterograde and retrograde amnesia, Pharm Biol, 2010; 48(2):234-240.
Singh D and Goel RK, Anticonvulsant effect of Ficus religiosa: Role of Serotonergic pathways, J Ethnopharmacol, 2009; 123(2):330-334.
Panday DR & Rauniar GP, Effect of root- extracts of Ficus benghalensis (Banyan) in memory, anxiety, muscle co-ordiantion and seizure in animal models, BMC Complementary and Alternative medicine, 2016; 16:429.
Ghani A, Medicinal Plants of Bangladesh: Chemical Constituents and Uses, Asiatic Society of Bangladesh, Dhaka, Bangladesh, 2nd edition, 1998.
Patil MS, Patil CR, Patil SW & Jadhav RB, Anticonvulsant activity of aqueous root extract of Ficus religiosa, J Ethanopharmacol, 2011; 133(1):92.
Singh K, Rauniar G & Sangraula H, Experimental study of neuropharmacological profile of Euphorbia pulcherrima in mice and rats, J Neurosci Rural Pract, 2012; 3:311.
Vogel H, Vogel HW, Schölkens BA, Sandow J, Müller G, Vogel WF. Drug Discovery and Evaluation: Pharmacological Assays. 2nd ed. Springer; 2002. P.146-151.
Medhi B, Prakash AJ. Practical Manual of Experimental and Clinical Pharmacology. 1st ed. Jaypee Brothers, Medical Publishers; 2010. P. 45-48. .
Kulkarni SK. Handbook of Experimental Pharmacology. 3rd ed. Vallabh Prakashan: Panjab University Chandigarh; 2010. P 36-39.
Singh D, Singh B and Goel RK, Role of saponins for the anticonvulsant effect of adventitious roots of Ficus religiosa, Pharm Biol, 2012; 50 (7):816.
Wigdor S, Wilcox GL, Central and systemic morphine- induced antinociception in mice: contribution of descending serotonergic and noradrenergic pathways, J pharmacol Exp Ther, 1987; 242:90-95.
Macdonald RL, Kelly KM, Antiepileptic drug mechanism of action, Epilepsia, 1995; 36:2-12.
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