PLGA Nanomedicine

Authors

  • Xiaochai Zhu School of Pharmacy, Nanjing University of Chinese Medicine,

Abstract

Poly lactic-co-glycolic acid (PLGA) based nanoparticles are wildly used for the delivery of bioactive compounds such as dexamethasone, curcumin, azithromycin, doxorubicin and indocyanine green. It was found that those polymeric compounds can be effectively used for nanoparticle drug delivery. They are more biocompatible and lesser resistant in the case of targeted drug delivery. These are observed to have wide-ranging applications. Many of the PLGA polymers are being currently under research for commercial use and treatment. They have many fabrication techniques. It is imperative to understand their limitations in the future. There is a need for more research to overcome these limitations to develop drugs that are more efficient.

Keywords:

PLGA, Dexamethasone, Curcumin, nanomedicine, Indocyanine green

DOI

https://doi.org/10.22270/jddt.v7i3.1452

References

Park J H, Lee S, Kim J-H, Park K, Kim K, and Kwon I C. Polymeric nanomedicine for cancer therapy. Progress in Polymer Science. 2008, 33: 113-137

Nishiyama N. Nanomedicine: nanocarriers shape up for long life. Nature Nanotechnology. 2007, 2: 203

Duan Y, Pei K, Cai H, Tu S, Zhang Z, Cheng X, et al. Bioactivity evaluation-based ultra high-performance liquid chromatography coupled with electrospray ionization tandem quadrupole-time-of-flight mass spectrometry and novel distinction of multi-subchemome compatibility recognition strategy with Astragali Radix-Fructus Corni herb-pair as a case study. Journal of pharmaceutical and biomedical analysis. 2016, 129: 514-534

Cheng X. DEVELOPING ORGANIC AND INORGANIC NANOMEDICINE FOR CANCER THERAPY. Journal of Drug Delivery and Therapeutics. 2017, 7: 1-4

Kumari A, Yadav S K, and Yadav S C. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids and Surfaces B: Biointerfaces. 2010, 75: 1-18

Li H, Cheng X, Liu Y, Lee Y B, Kim D J, Ahn C-h, et al. Folate receptor-targeted lipid coated albumin nanoparticles (F-LCAN) for therapeutic delivery of RX-0201 (Archexin®), an antisense oligonucleotide against Akt-1. 2016,

Cheng X, Liu Q, Li H, Kang C, Liu Y, Guo T, et al. Lipid Nanoparticles Loaded with an Antisense Oligonucleotide Gapmer Against Bcl-2 for Treatment of Lung Cancer. Pharm Res. 2017, 34: 310-320; doi: 10.1007/s11095-016-2063-5.

Sun Y, Kang C, Liu F, and Song L. Delivery of Antipsychotics with Nanoparticles. Drug Development Research. 2016, 77: 393-399

Kang C, Sun Y, Zhu J, Li W, Zhang A, Kuang T, et al. Delivery of Nanoparticles for Treatment of Brain Tumor. Current Drug Metabolism. 2016, 17: 745-754

Xue X, Zhao N-Y, Yu H-T, Sun Y, Kang C, Huang Q-B, et al. Discovery of novel inhibitors disrupting HIF-1α/von Hippel–Lindau interaction through shape-based screening and cascade docking. PeerJ. 2016, 4: e2757

Li H, Quan J, Zhang M, Yung B C, Cheng X, Liu Y, et al. Lipid-Albumin Nanoparticles (LAN) for Therapeutic Delivery of Antisense Oligonucleotide against HIF-1alpha. Mol Pharm. 2016, 13: 2555-2562; doi: 10.1021/acs.molpharmaceut.6b00363.

Cheng X, and Lee R J. The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery. Adv Drug Deliv Rev. 2016, 99: 129-137; doi: 10.1016/j.addr.2016.01.022.

Duan Y, Pei K, Cai H, Tu S, Cheng X, Zhang Z, et al. Strategy of integrated evaluation on treatment of traditional Chinese medicine as ‘interaction of system to system’and establishment of novel fuzzy target contribution recognition with herb-pairs, a case study on Astragali Radix-Fructus Corni. Molecular and Cellular Endocrinology. 2016, 434: 219-237

Campolongo M J, Tan S J, Xu J, and Luo D. DNA nanomedicine: Engineering DNA as a polymer for therapeutic and diagnostic applications. Advanced drug delivery reviews. 2010, 62: 606-616

Han R, Sun Y, Kang C, Sun H, and Wei W. Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and doxorubicin for enhanced therapeutic efficacy. Journal of Drug Targeting. 2017, 25: 140-148

Sun Y, Kang C, Zhang A, Liu F, Hu J, Zhong X, et al. Co-delivery of dual-drugs with nanoparticle to overcome multidrug resistance. European Journal of BioMedical Research. 2016, 2: 12-18

Song L, Kang C, Sun Y, Huang W, Liu W, and Qian Z. Crocetin Inhibits Lipopolysaccharide-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells. Cellular Physiology and Biochemistry. 2016, 40: 443-452

Park J, Fong P M, Lu J, Russell K S, Booth C J, Saltzman W M, et al. PEGylated PLGA nanoparticles for the improved delivery of doxorubicin. Nanomedicine: Nanotechnology, Biology and Medicine. 2009, 5: 410-418

Liu Z-l, Zhang R-m, Meng Q-g, Zhang X-c, and Sun Y. Discovery of new protein kinase CK2 inhibitors with 1, 3-dioxo-2, 3-dihydro-1 H-indene core. MedChemComm. 2016, 7: 1352-1355

Sun H, Zhu J, Chen Y, Sun Y, Zhi H, Li H, et al. Docking Study and Threeâ€Dimensional Quantitative Structureâ€Activity Relationship (3Dâ€QSAR) Analyses and Novel Molecular Design of a Series of 4â€Aminoquinazolines as Inhibitors of Aurora B Kinase. Chinese Journal of Chemistry. 2011, 29: 1785-1799

Guo X K, Sun H P, Shen S, Sun Y, Xie F L, Tao L, et al. Synthesis and evaluation of gambogic acid derivatives as antitumor agents. Part III. Chemistry & biodiversity. 2013, 10: 73-85

Zhou Y, Xu X, Sun Y, Wang H, Sun H, and You Q. Synthesis, cytotoxicity and topoisomerase II inhibitory activity of lomefloxacin derivatives. Bioorganic & medicinal chemistry letters. 2013, 23: 2974-2978

Zheng C, Zheng M, Gong P, Jia D, Zhang P, Shi B, et al. Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging. Biomaterials. 2012, 33: 5603-5609

Mohammadi G, Valizadeh H, Barzegar-Jalali M, Lotfipour F, Adibkia K, Milani M, et al. Development of azithromycin–PLGA nanoparticles: Physicochemical characterization and antibacterial effect against Salmonella typhi. Colloids and

Surfaces B: Biointerfaces. 2010, 80: 34-39

Chen Y, Bian Y, Sun Y, Kang C, Yu S, Fu T, et al. Identification of 4-aminoquinoline core for the design of new cholinesterase inhibitors. PeerJ. 2016, 4: e2140

Kang C, Sun Y, Wang M, and Cheng X. Nanosized camptothecin conjugates for single and combined drug delivery. European Journal of BioMedical Research. 2016, 2: 8-14

Qiao H, Fang D, Chen J, Sun Y, Kang C, Di L, et al. Orally delivered polycurcumin responsive to bacterial reduction for targeted therapy of inflammatory bowel disease. Drug Delivery. 2017, 24: 233-242

XU S-h, Chen K, CHEN M-l, ZHOU P-p, HE G-w, CUI Y-j, et al. Dynamic expression of AQP4 in early stageof ischemia/reperfusion rats and cerebral edema. Chinese Pharmacological Bulletin. 2016: 1433-1441

Yang Z, Xie J, Zhu J, Kang C, Chiang C, Wang X, et al. Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation. Journal of Controlled Release. 2016, 243: 160-171

Waller A P, George M, Kalyanasundaram A, Kang C, Periasamy M, Hu K, et al. GLUT12 functions as a basal and insulin-independent glucose transporter in the heart. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2013, 1832: 121-127

Mathew A, Fukuda T, Nagaoka Y, Hasumura T, Morimoto H, Yoshida Y, et al. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease. PLoS one. 2012, 7: e32616

Liu F, Sun Y, Kang C, and Zhu H. Pegylated Drug Delivery Systems: From Design to Biomedical Applications. Nano LIFE. 2016, 6: 1642002

Sun Y, Kang C, Yao Z, Liu F, and Zhou Y. Peptide-Based Ligand for Active Delivery of Liposomal Doxorubicin. Nano LIFE. 2016, 6: 1642004

Kang C, Qin J, Osei W, and Hu K. Regulation of protein kinase C-epsilon and its age-dependence. Biochemical and Biophysical Research Communications. 2017, 482: 1201-1206

Sun Y, and Kang C. Self-Assembly of Peptides into Hydrogel. Journal of Organic & Inorganic Chemistry. 2016,

Yao Z, Sun Y, and Kang C. Structure and Self-Assembly of Multicolored Naphthalene Diimides Semiconductor. Nano LIFE. 2016, 6: 1642007

Zhong X, Sun Y, Kang C, and Wan G. The theory of dielectrophoresis and its applications on medical and materials research. European Journal of BioMedical Research. 2017, 2: 7-11

Wang Q, Wang J, Lu Q, Detamore M S, and Berkland C. Injectable PLGA based colloidal gels for zero-order dexamethasone release in cranial defects. Biomaterials. 2010, 31: 4980-4986

Published

2017-05-14
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How to Cite

1.
Zhu X. PLGA Nanomedicine. J. Drug Delivery Ther. [Internet]. 2017 May 14 [cited 2026 Jan. 18];7(3):84-6. Available from: https://www.jddtonline.info/index.php/jddt/article/view/1452

How to Cite

1.
Zhu X. PLGA Nanomedicine. J. Drug Delivery Ther. [Internet]. 2017 May 14 [cited 2026 Jan. 18];7(3):84-6. Available from: https://www.jddtonline.info/index.php/jddt/article/view/1452