REVIEW ON APPLICATION AND FACTOR AFFECTING AND OFFICIAL MONOGRAPHS IN DISSOLUTION PROCESS
Abstract
Dissolution testing is a critical methodology which is widely utilized in the development of a new pharmaceutical product. The test, in its simplest form, consists of placing the formulation in a dissolution apparatus containing suitable dissolution medium, allowing it to dissolve over a specified period of time and then assaying the resultant solution using appropriate analytical method to determine the amount of drug. Dissolution tests are relevant for an array of investigations like drug degradation profiles, stability and shelf life studies, physical and mechanical testing of dosage forms, incoming QC testing on raw materials etc. The present review outlines the recent findings on various dissolution apparatuses, their modifications, methods for degassing of media like Helium sparging, Heating and filtering, Vacuum degassing, sonication and dissolution testing of various dosage forms like Immediate Release (IR) Dosage forms, Delayed Release Dosage Forms, Extended Release Dosage Forms, Transdermal Delivery Systems, Powders, Chewable Tablets, Buccal Tablets, Chewing Gums, Soft Gelatin Capsule , Aerosols, Suppositories and other Semisolids.
Keywords: Dissolution , Factor affecting dissolution , Dissolution apparatusDOI
https://doi.org/10.22270/jddt.v7i3.1422References
Brahmankar DM, Jaiswal SB. Biopharmaceutical and pharmacokinetics A treatise Vallaabh Prakashan, First edition, New Delhi 1995, pp 18-50.
Kushwaha P, Handbook of pharmaceuticak technology,first edition published by jaypee brothers Medical publishers (P) Ltd.2015,pp 60-72.
Gray VA, Brown CK, Dressman JB, Leeson LJ, A New General Information Chapter on Dissolution. Pharm. Forum 2001, 27 (6), 3432–3439.
Ross MSF, Rasis M, Mega Paddle,A Recommendation to Modify Apparatus Used in the USP General Test for Dissolution 711 . Pharm. Forum 1998, 24 (3), 6351–6359.
Howard C, Lloyd V, Allen J, Nicholas G, Popovich, Pharmaceutical Dosage Forms and Drug Delivery Systems. Baltimore,Maryland: Lippincott Williams & Wilkins, 7th edition, 1999,
Reeta Rani Thakur, Sonia Narwal. Orally disintegrating preparations, recent advancement in formulation and technology. Journal of Drug Delivery & Therapeutics, 2012, 2(3), 87-96.
Jayaprakash S, Mathew Ebin P Sovichan, Lalithcherian, Rani S, Praveen Raj R. Study on the effects of various disintegrants dispersible tablets. International Research Journal of Pharmacy, 2012, 3(5), 146-152.
United States Pharmacopeial Convention, Inc. United States Pharmacopeia 26. Rockville,Maryland: United States Pharmacopeial Convention, Inc. 2003.
Qureshi SA. The USP Dissolution Apparatus Suitability Test.†Drug Information Journal. 1996; 30;1055-1061.
Desai D, Wang J, Wen H , Li X Timmins P. Formulation design, challenges, and development considerations for fixed dose combination (FDC) of oral solid dosage forms. Pharmaceutical Development and Technology, 2013, 18(6), 1265-1276.
Gupta AK, Arshad S, Poulter NR, Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents, a meta-analysis. Hypertension, 2010, 55(2), 399–407.
Akazawa M, Fukuoka K. Economic impact of switching to fixed-dose combination therapy for Japanese hypertensive patients, a retrospective cost analysis. a BMC Health Services Research, 2013, 124.
World Health Organization. WHO Expert Committee on Malaria (1998, Geneva, Switzerland). WHO expert committee on malaria, twentieth report. World Health Organization Technical Report Series, 2000, 892.
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