ADVANCES IN SOLID DISPERSION TECHNOLOGY AND ITS APPLICATIONS IN THE DEVELOPMENT OF SOLID DOSAGE FORMS

Abstract

Amorphous solid dispersions are extensively used as a strategy for improving the bioavailability of poorly water - soluble compounds in past decade. Therefore, the application of this technique proves to be an important stratagem for pharmaceutical companies. However, the in - depth knowledge of the solid dispersion is desired for the scale up of formulation, from laboratory scale to industrial scale. Hydrophilic polymers are used for preparation of solid dispersion such as polyvinylpyrrolidone, hydroxylpropylmethylcellulose, polyethylene glycols. Recently some new carriers like cyclodextrins, gelucire, vitamin E TPGS and many more has been explored as a carrier for the solid dispersion technology. Using of these polymers has its own advantages and disadvantages. Method of preparation also influences dissolution profile of solid dispersion. In this review, we intend to discuss the recent advances in the field of solid dispersions and their use in multicomponent systems. This review also elaborates the method of preparation and its correlation with the in-vivo absorption properties.

Keywords: Solid dispersion, Multicomponent systems, Hydrophilic carriers, Bioavailability