NATURAL POLYMER VIS A VIS SYNTHETIC POLYMER FOR SOLUBILITY ENHANCEMENT OF SIMVASTATIN

Authors

  • Seema V Pattewar Sanjivani Institute of Pharmacy and Research, Kopargaon, India-423603
  • Deepak N Patil Sanjivani Institute of Pharmacy and Research, Kopargaon, India-423603
  • Bharti V Bakade P. Wadhwani college of Pharmacy,Yavatmal

Abstract

The enhancement of the oral bioavailability is currently one of the greatest challenges in the development of poorly water soluble drugs. The main objective of work to enhance solubility of Simvastatin (SIM) by use of natural polymer, chitosan (CHI) and Hydroxy propyl methyl cellulose E3LV (HPMCE3LV), synthetic polymer to produce cost effective formulation. Physical mixture, co-grinding method, spray drying method are compared .Co-grinding method applied for preparation of drug polymer complex and compared with the solubility and dissolution of marketed preparation.

DOI

https://doi.org/10.22270/jddt.v2i3.129

Published

2012-05-14
Statistics
Abstract Display: 445
PDF Downloads: 735

How to Cite

1.
Pattewar SV, Patil DN, Bakade BV. NATURAL POLYMER VIS A VIS SYNTHETIC POLYMER FOR SOLUBILITY ENHANCEMENT OF SIMVASTATIN. J. Drug Delivery Ther. [Internet]. 2012 May 14 [cited 2026 Apr. 30];2(3). Available from: https://www.jddtonline.info/index.php/jddt/article/view/129

Issue

Vol. 2 No. 3 (2012): Volume 2, Issue 3, May-June 2012

Section

Research

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

How to Cite

1.
Pattewar SV, Patil DN, Bakade BV. NATURAL POLYMER VIS A VIS SYNTHETIC POLYMER FOR SOLUBILITY ENHANCEMENT OF SIMVASTATIN. J. Drug Delivery Ther. [Internet]. 2012 May 14 [cited 2026 Apr. 30];2(3). Available from: https://www.jddtonline.info/index.php/jddt/article/view/129
Crossref
Scopus
Google Scholar
Europe PMC