MICROENCAPSULATION BY SOLVENT EVAPORATION METHOD OF BCS CLASS 4 DRUGS FOR BIOAVAILABILITY ENHANCEMENT

Abstract

The microencapsulation process is used for size reduction with enclosing polymer coat on active pharmaceutical ingredient. The microencapsulation process used in present study is solvent evaporation process which formulated prior as o/o emulsification process. The polymer for encapsulation was selected based on drug entrapment efficiency and concentration of polymer mix was selected in ratio 1:2, further ratio was adjusted in central composite design for application of DOE in which independent variables was drug release after 2 hours and permeability across bio membrane after 4 hours. Results are shown revealed significant rise in bioavailability of drug than pure API. Scanning electron microscopy referred the size of microcapsule were in range of 10 - 5000 ðœ‡m. They were spherical in shape with a rough surface and good solubility. Microcapsule were seen in SEM images are sphere with rough surfaces in all batches irrelevant of drug used. Drug encapsulation efficiencies of all the polymes were higher than 90%, which suggested that this method has potential to prepare microcapsules with efficient drug loading and increased bioavailability.

Keywords: Bioavailability Enhancement, Microencapsulation, Solvent Evaporation Technique, Design of Experiment (DOE), Quality by Design (QbD), Central Composite Design.