Formulation and Evaluation of Liposome by Thin Film Hydration Method
Formulation of Liposome
Abstract
Liposomes are the most advance formulation for targeting and controlled drug delivery system. These liposomes are generally administered by intra-venous route. In this work the liposome was prepared by using thin film hydration method. The formulated liposome is evaluated or characterised by using zeta sizer, Encapsulation efficiency, Entrapment efficiency, In vitro drug release. Main things are drug which are used for formulation of liposome was Diclofenac sodium, it having anti-inflammatory and anti-pyretic effect. The Diclofenac sodium having several adverse effects, such as depression of renal function, Liver failure for repeated administration, Local mucosal irritation, gastritis. To avoid this adverse effect Diclofenac sodium are incorporate in liposomal formulation. By formulating liposomal formulation, the bioavailability of Diclofenac sodium increase. In conventional dosage form bioavailability of diclofenac sodium is 50℅. But in liposomal formulation bioavailability of this drug increase. The final result includes that diclofenac liposome formulation shows more sustained and prolong anti-inflammatory activity.
Keywords: Diclofenac sodium, Liposome, Anti-inflammatory activity.
Keywords:
Diclofenac sodium, Liposome, Anti-inflammatory activityDOI
https://doi.org/10.22270/jddt.v11i1.4677References
Dua JS, Rana AC, Bhandari Ak. Liposome: method of preparation and application. International Journal of Pharmaceutical Studies and Research 2012; 3(2):14.
Akbar Zadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, et.al. Liposome: classification, preparation, and applications. Nanoscale Research Letters 2013; 8:2.
Pistone S. Formulation and evaluation of polysaccharide and liposome-based nano systems for improved targeting to the oral cavity; hesis for the degree of Philosophiæ Doctor Department of Pharmaceutics. School of Pharmacy University of Oslo – Norway 2016:11.
Marripati S, Umasankar K, Reddy PJ. A revive on liposome. International Journal of Research in Pharmaceutical and Nano Sciences 2014; 3(3):159-60.
Jithan AV, Swathi M. Development of topical Diclofenac sodium liposomal gel for better anti-inflammatory activity. International Journal of Research in Pharmaceutical and Nano Sciences 2010; 3(2):986-87.
Lankalapalli S, Vinai Kumar Tenneti VS, Adama R. Preparation and evaluation of liposome formulations for poorly soluble drug itraconazole by complexation. Scholars Research Library der Pharmacia Letter 2015; 7(8):3.
Moghimipour E, Salami A, Monjezi M. Formulation and Evaluation of Liposomes for Transdermal Delivery of Celecoxib. Jundishapur J Nat Pharm Prod 2015; 10(1):2-3.
Jadhav MP, Nagarsenker MS, Gaikwad V, Samad A, Kshirsagar NA. Formulation and Evaluation of Long Circulating Liposomal Amphotericin B: A Scinti-kinetic Study using 99mTc in BALB/C Mice. Indian Journal of Pharmaceutical Sciences 2011; 73(1):57-64
Shivhare UD, Ambulkar DU, Mathur VB, Bhusari KP, Godbole MD. Formulation and evaluation of Pentoxifylline Liposome formulation. Digest Journal of Nanomaterials and Biostructures 2009; 4(4):859-62.
Umbarkar M.G. Rindhe P.S. Chandrawanshi S. Formulation and Evaluation of Polymeric nanoparticle by nanoprecipitation method. Journal of drug delivery and therapeutics 2020; 10(5s):136-142.
Patel RP, Patel H, Baria AH. Formulation and Evaluation of Liposomes of Ketoconazole. International Journal of Drug Delivery Technology 2009; 1(1):18.
Subash Chandran MP, Pandey VP. Formulation and evaluation of gliclazide loaded liposomes. Scholars Research Library der Pharmacia Letter 2016; 8(11):63-64.
Ghule MM, Bhoyar GS. Formulation and Evaluation of modified liposome for transdermal drug. Journal of Developing Drugs 2018; 7(1):2-3.
Latha K, Lalitha P, Nasseb Basha SK. Formulation and Evaluation of Darifenacin Hydrobromide Nano-Liposomes. Journal of Chemical and Pharmaceutical Research 2017; 9(8):174-76.
De A, Nagaswamy Venkatesh D. Design and evaluation of liposomal delivery system for L-Asparaginese. Journal of Applied Pharmaceutical Science 2012; 2(8):112-17.
Song J, Shi F, Zhang Z, Zhu F, Xue J, Tan X, et.al. Formulation and Evaluation of Celastrol-Loaded Liposomes. Molecules 2011; 16:7888.
Vijay kumar M.R, Abdul hasan sathali A, Arun.k. Formulation and Evolution of diclofenac potassium ethosome. International Journal of Pharmacy and Pharmaceutical Sciences 2010; 2(4):83.
Sharma S, Sharma A. Development, Formulation, characterization and evaluation of elastic liposomal formulation of chlorzoxazone for transdermal delivery. International Journal of Therapeutic Applications 2012; 2:15.
Ibrahim Abd-Allah F. Development, Characterization and Ex vivo Evaluation of Various Liposome-encapsulated Aceclofenac Formulations. British Journal of Pharmaceutical Research 2016; 9(4):7.
Sailor G, Seth AK, Parmar G, Chauhan S, Javia A. Formulation and in vitro evaluation of berberine containing liposome optimized by 32 full factorial designs. Journal of Applied Pharmaceutical Science 2015; 5(7):24-25.
Sangeetha SS, Karki R. Formulation and evaluation of liposomes in Carbopol gels for mixed vaginal infections. Scholars Research Library der Pharmacia Letter 2015; 7(5):293.
Jino Nesalin JA, Gowthamrajan K, Somasekhara CM. Formulation and Evolution of Nanoparticles containing Flutamide. International Journal of Chemtech Research 2009; 1(4):1332
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