Effect of Aluminium and Aqueous extract of Rosmarinus officinalis on rat Brain: Impact on Neurobehavioral and Histological study

Aluminium and Aqueous extract of Rosmarinus officinalis

  • Zakia Lahouel Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria
  • Omar Kharoubi Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria
  • Amina Boussadia Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria
  • Zohra Bekkouche Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria
  • Abdelkader Aoues Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria

Abstract

'Rosmarinus officilnalis' is a plant used in Mediterranean diet and traditional medicine, possessing various antioxidant and cytoprotective bioactivities. In this study, we investigated the potential neuroprotective efficacy of aqueous Rosemary extract (AER) against neurotoxicity induced by Aluminum (Al), in terms of behavioral, biochemical and histological aspects in young rats. an intraperitoneal injection of Al, at the weekly dose of 60mg/Kg was given to the animals. A treatment of 150mg/Kg/day of AER was administered by gavage over periods of 6 or 12weeks. Al caused intense changes over time in body and brain weight, increase in neurological disorders such as depression, anxiety, and deficiency in memory skills. Results show also disturbances in locomotors activity, with a significant inhibition of AchE and increase LDH activity compared to control. Additionally, Al induced structural damages in the cerebral cortex, and the CA1 region of hippocampus. However, treatment with AER resulted in improved depression and anxiety state, locomotors activity and restored memory skills. Results show that AER increase the AchE activity and decreased neuronal loss in the cerebral cortex and the CA1 region of hippocampus with the 6weeks treatment but induced disruption and structural modification of brain tissue after the 12 weeks treatment. The Aqueous extract of Rosemary possess a neuroprotector and corrective effect against neurological alterations induced by Aluminum, but when administered over a long period of time, the extract can cause a no beneficial effect and morphologic modifications in cerebral tissue and behavior test.


Keywords: Rosmarinus officinalis, Aluminum, neuro-behavior, brain structure.

Keywords: Rosmarinus officinalis, Aluminum, neuro-behavior, brain structure

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Author Biographies

Zakia Lahouel, Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria

Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria

Omar Kharoubi, Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria

Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria

Amina Boussadia, Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria

Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria

Zohra Bekkouche, Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria

Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria

Abdelkader Aoues, Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria

Laboratory of Experimental biotoxicology, biodepollution and phytoremediation, Faculty of Natural and Life Sciences, University Oran1 Ahmed Ben Bella, Oran, Algeria

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Lahouel Z, Kharoubi O, Boussadia A, Bekkouche Z, Aoues A. Effect of Aluminium and Aqueous extract of Rosmarinus officinalis on rat Brain: Impact on Neurobehavioral and Histological study. JDDT [Internet]. 15Jul.2020 [cited 30Sep.2020];10(4):179-87. Available from: http://www.jddtonline.info/index.php/jddt/article/view/4252