Alginate Microspheres: The Innovative Approaches to Production of the Microbeads/Micro-Particles
Multiparticulate dosage form is pharmaceutical formulations where the active substance is in the form of a number of small independent subunit such as, granules, microparticle, beads, and microspheres. Multiparticulate drug delivery systems are specifically suitable for achieving delayed and sustained release oral formulations with a minimum risk of dose dumping, local irritation, systemic toxicity, and variation in rate of bioavailability as they are less dependent on gastrointestinal transit time and offers many advantages over unit particulate dosage forms. Microbeads are small, sphere shaped, systematically produced free-flowing properties, semi-spherical solid units. Microbeads are the agglomerates of about size ranging from 0.5 mm to 1.0 mm, obtained from various starting materials and utilizing different innovative techniques. A blend of multiparticulate can also be used to provide the desired drug release profile. These round shaped particles produced by mostly principle of atomization technique.Among various different innovative techniques Vibration technology, Electrostatic bead generator, Jetcutter technology, electrostatic forces, dropping method and a mechanical cutting device are few of many. In current article it describes about the total methods involved and their working principles with diagrams were clearly illustrated. Now a days sodium alginate beads were designed by these technologies mostly in relative to microencapsulation techniques.
Keywords: Atomization, Vibrating technology, Jetcutter device, Electrostatic bead generator Dropping method and electro-spray technology
2. Serp D, Cantana E, Heinzen C, Von Stockar U, Marison I.W., Characterization of an encapsulation device for the production of monodisperse alginate beads for cell immobilization. Biotechnol. Bioeng. 2000; 70:41–53.
3. Shwinger C, Klemenz A, Busse K, Kressler J., Encapsulation of living cells with polymeric systems. Macromol. Symp. 2004; 210:493-499.
4. Shwinger C, Klemenz A, Busse K, Kressler J., Encapsulation of living cells with polymeric systems. Macromol. Symp. 2004; 210: 493- 499.
5. Canaple L, Rehor A, Hunkeler D., Improving cell encapsulation through size control. J. Biomater. Sci. Polym. 2002; 13:783-796.
6. Robitaille R, Pariseau J.F, Leblond F.A, Lamoureux M, Lepage Y, Halle J.P., Studies on small l (<350´m) alginate-poly-L-lysine microcap sules. III. Biocompatibility of smaller versus standard microcapsules. J. Biomed. Mater. Res. 1999; 44:116-120.
7. Maria Raytchinova Kosseva., Immobilization of Microbial Cells in Food Fermentation Processes. Food Bioprocess Technol. 2011; 4:1089-1118.
8. Serp D, Cantana E, Heinzen C, Von Stockar U, Marison I., Characterization of an encapsulation device for the production of monodisperse alginate beads for cell immobilization. Biotechnol. Bioeng. 2000; 70: 41-53
9. Shwinger C, Klemenz A, Busse K, Kressler J., Encapsulation of living cells with polymeric systems. Macromol. Symp. 2004; 210: 493-499.
10. Yan Zhou , Shinichiro Kajiyama , Hiroshi Masuhara, Yoichiro Hosokawa, Takahiro Kaji, Kiichi Fukui., A new size and shape controlling method for producing calcium alginate beads with immobilized proteins. J. Biomedical Science and Engineering, 2009; 2:287-293.
11. Boyd J, Parkinson C, Sherman P., Factors affecting emulsion stability, and the HLB concept. J. Colloid Interface Sci. 1972; 4:359-370.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).