FORMULATION AND EVALUATION OF VEGETABLE OIL BASED EMULGEL OF FLUCONAZOLE
Aim: The aim of the study was to prepare an emulgel formulation of fluconazole using vegetable oil (sesame oil) and compare with liquid paraffin Fluconazole emulgel. Emulgel has emerged as a promising drug delivery system for delivery of hydrophobic drug. Fluconazole is an anti- fungal medication use for a number of fungal infections it belong to a group of medicine called azole antibiotics. The edible oil is used as it has no side effects.
Method: The oil phase of emulsion was prepared by dissolving span 20 in light liquid paraffin and vegetable oil & drug. The aqeous phase is prepared by dissolving tween 80 in purified water. Methyl & Propyl gel phase was prepared by dispersing carbopol 940 in purified water & both phases are mixed with continuous stirring. The pH is adjusted using TEA (tri-ethanol-amine).
Results: The prepared emulgel was also evaluated for their physical properties, pH, drug content, viscosity, spreadability and swelling index. The pH of formulation with liquid paraffin & vegetable oil. The pH of formulation with liquid paraffin & edible oil pH in range 5 to 7.0 and the viscosity of both emulgel are almost same in range of 1134-2000 centipoises.
Conclusion: It was concluded that vegetable oil based emulgel are stable and effective and can be used instead of liquid paraffin based emulgel.
Keywords: Emulgel, Hydrophobic drug, Vegetable oil, Fluconazole, Topical drug delivery.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).