Effect of L-arginine amino acid on liver regeneration after hepatocyte damage in rats: An experimental study.
Abstract
The aim of the work was to check the therapeutic effect of L-arginine for liver cell regeneration. L-arginine is a semi-essential amino acid works as a nitric oxide precursor. Sustained released matrix beads of L- arginine were developed and tested for its hepatoprotective effect in rats (paracetamol was used to induce liver toxicity). Various biochemical tests of hepatic damage like SGPT, SGOT, ALP and bilirubin were done in all groups of animals. A toxic dose of paracetamol enhanced the SGPT, SGOT, ALP and bilirubin levels followed by treatment with silymarin as standard and L-arginine as test drugs. Histopathological studies also supported the hepatoprotective effect, containing L-arginine.Animal group treated with L-arginine indicated a significant decrease in the levels of biochemical markers to the near normal levels. The liver section of toxicant animals showed degenerative changes, aggregates of mononuclear inflammatory cells while treatment with formulations containing L-arginine helped in regaining the normal hepatic architecture, hence it can be concluded that significant effect of L-arginine was observed in liver cell regeneration.
Keywords: Hepatoprotective, L-arginine, Silymarin, SGPT, SGOT.
Downloads
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.