Overview on virosomes as a novel carrier for drug delivery

  • Siraj N Shaikh Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415
  • Shahid Raza Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415
  • Mohd. Aslam Ansari Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415
  • G.J. Khan Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415
  • Siddiqi Hifzurrahman MD Athar Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415

Abstract

As from the last eras number of the revolution in the drug delivery technologies have been seen to attain the targeted drug delivery or site specific action of the drug. The prospects of the drug delivery by using biomimetic nanoparticles such as virosomes is an motivating research & development field as showing targeted action by fusion with the targeted action by fusion through target cell. It can be engaged as vehicle & vaccines furthermore victory of virosomal drug delivery depends on the method used to make the encapsulated bioactive materials, characterization & formulation of finished products. They are reconstituted viral envelopes that can be conveyance of different macromolecules as these are biocompatible, biodegradable, nonautoimmunogenic. Virosomes denotes such a unique system for presentation of antigen to immune system. Peptides, nucliecacid & medications such as antitoxins, anticancer agents &steroids can be encapsulated. This review focus on various aspects of Virosomes, such as Structure of Virosomes Component, Advantages, disadvantages, Method of preparation, Characterization, recent Patents and applications of Virosomes etc.


Key words: Neurodegenerative, Nonimmunogenic, Endolysosomal, Cryoprotectants, Applications.

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Author Biographies

Siraj N Shaikh, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415

Shahid Raza, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415

Mohd. Aslam Ansari, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415

G.J. Khan, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415

Siddiqi Hifzurrahman MD Athar, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist. Nandurbar, Maharashtra, India-425415

References

1. Kalra N, Dhanya V, Saini V, Jeyabalan G. Virosomes: As a Drug Delivery Carrier. American Journal of Advanced Drug Delivery 2013; 1(1):29-35.
2. Gaurav B, Manisha K, Vilasrao K. Virosome – drug and vaccine delivery system. World Journal of Pharmacy and Pharmaceutical Sciences 2014; 3(10):437-447.
3. Singh N, Gautam S, Kumari N, Kaur R, Kaur M. Virosomes as Novel drug delivery System: An Overview. Pharma Tutor 2017; 5(9):47-55.
4. Patel S.S, Patel M.J, Patel N.M. Need, Development and application of Virosomal system in medicine. International Journal of Pharmaceutical Sciences and Nanotechnology 2010; 3(3):1065-1074.
5. Idris N, Chilkawar R, Nanjwade B, Srichana T, Shafioul A. Nanotechnology Based Virosomal Drug Delivery Systems. Journal of Nanotechnology and Materials Science 2014; 1(1):27-35.
6. Babar MM, Zaidi N, Kazi A, Rehman. A Virosomes-Hybrid Drug Delivery Systems. Antivirals & Antiretrovirals 2013; 5(7):166-172.
7. Gowtham M, Pulak M, Krishnakumar KK. Virosomes: A Novel strategy for delivery of drugs and targeting: An overview. Journal of Pharmaceutical and scientific innovation 2012; 1(5):31-35.
8. Kamboj S, Saini V, Magon N, Bala S, Jhawat V. Vesicular drug delivery systems: A novel approach for drug targeting. International Journal of Drug Delivery 2013; 5 (2):121-130.
9. Lee S, Nguyen MT. Recent Advances of Vaccine Adjuvants for Infectious Diseases. Immune network 2015; 15(2):51-57.
10. Daemen T, Mare A, Bungener L, Jonge J, Huckriede A, Wilschut J. Virosomes for antigen and DNA delivery. Advanced Drug Delivery Reviews 2005; 57:451–463.
11. Martinho N, Damge C, Reis C. Recent Advances in Drug Delivery Systems. Journal of Biomaterials and Nanobiotechnology 2011; 2:510-526.
12. Inamdar N, Pulgamwar G, Jadhav K. Virosomes: New Frontier for Targetting Drug and biological molecules. Asian journal of Pharmaceutical technology & Innovation 2015; 3(12):92-103.
13. Rebecca A, Amacker M, Moser C, Fabian B, Garnier C. Pulmonary Delivery of Virosome-Bound Antigen Enhances Antigen-Specific CD4+ T Cell Proliferation Compared to Liposome-Bound or Soluble Antigen. Pulmonary Immune Modulation by Virosomes 2017; 8:1-16.
14. Cusi M, Applications of Influenza Virosomes as a Delivery System. Human Vaccines. 2006; 2(1):1-7.
15. Sharma R, Yasir M. Virosomes: A Novel Carrier for Drug Delivery. International journal of Pharma Tech Research.2010; 2(4):2327-2339.
16. Liu H.Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment. Acta Pharm. 2015; 64:105–116.
17. Kumari A, Singla R, Guliani A, Yadav SK. Nanoencapsulation for Drug Delivery. EXCLI Journal 2014; 13:265-286.
18. Kapoor D, Vyas RB, Lad C, Patel M. Amultipurpose and novel carrier for drug delivery and targeting virosomes. Journal of Drug Delivery & Therapeutics 2013; 3(5):143-147.
19. Rathore P, Swami G. Virosomes: a novel vaccination technology. IJPSR 2012; Vol. 3(10):3591-3597.
20. Sen R, Gupta R, Singh S, Mantry S, Das S. A Review on Cubosome and Virosome: the novel drug delivery system.UJPSR 2017; 3(1):24-33.
21. Sharma S. Novel drug delivery approach in cancer therapy. Journal of Pharmacy & pharmaceutical Science 2016; 5(2):120-125.
22. Moser C. Influenza virosomes applied in current and future vaccines. Virus like particle as vaccines 2017; 1-24.
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How to Cite
Shaikh, S. N., Raza, S., Ansari, M. A., Khan, G., & Athar, S. H. M. (2019). Overview on virosomes as a novel carrier for drug delivery. Journal of Drug Delivery and Therapeutics, 8(6-s), 429-434. https://doi.org/10.22270/jddt.v8i6-s.2163