Formulation and evaluation sustained release mucoadhesive gastroretentive pantoprazole sodium sesquihydrate tablets for anti–ulcer
Abstract
Objective: The objective of this research work is to develop and evaluate the mucoadhesive gastroretentive tablets of an anti – ulcer drug for sustain release. Materials and Methods: Mucoadhesive tablets were prepared by direct compression method using Hydroxy propyl methyl cellulose K4M, Carbopol 940 NF and Guar gum in the various drug – polymer ratios. The prepared tablets were evaluated for their pre and post compression parameters. In this study the optimized formulation was obtained within the specified limits. Results: The final optimized formulation was showed mucoadhesion time 12 h, mucoadhesive strength of tablets were ready with HPMC K4M, Carbopol 940 NF and gum were found to be 45 g and the extreme proportion of drug release was obtained 97.11% at the completion of 12 h. The drug release mechanism for optimized formulations of pantoprazole mucoadhesive sustain release tablets was observed to be zero order kinetic model. Conclusion: The formulation of hydroxy propyl methyl cellulose showed excellent mucoadhesive ability and a suitable drug release pattern.
Keywords: Pantoprazole sodium sesquihydrate, Gastroretentive, mucoadhesive polymers
DOI
https://doi.org/10.22270/jddt.v8i6-s.2145References
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Pantoprazole sodium sesquihydrate drug profile from PubChem and drug bank.
www.wikepedia.com of pantoprazole sodium sesquihydrate.
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