NIOSOMES: PRESENT SCENARIO AND FUTURE ASPECTS
Abstract
Drug targeting is a kind of phenomenon in which drug gets distributed in the body in such a manner that the drug interacts with the target tissue at a cellular or subcellular level to achieve a desired therapeutic response at a desire site without undesirable interactions at other sites. This can be achieved by modern methods of targeting the drug delivery system such as niosomes. Niosomes are the type of non-ionic surfactant vesicles, which are biodegradable, non-toxic, more stable and inexpensive, a new approach to liposomes. Their structure similar to liposome and hence they can represent alternative vesicular systems with respect to liposomes. The niosomes have the tendency to load different type of drugs. This review article represents the structure of niosome, advantages, disadvantages, the methods for niosome preparation and characterization of pharmaceutical NSVs.
Keywords: Niosome, Cholesterol, Hydrophilic and Lipophilic drugs, Surfactant, Targeted delivery Bioavailability Improvement, Factors, Applications.
Keywords:
Niosome, Cholesterol, Hydrophilic and Lipophilic drugs, Surfactant
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References
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2. Handjani-Vila RM, Dispersion of Lamellar Phases of Nonionic Lipids In Cosmetic Products, Int J Cosmetic Sci, 1979; 1(5):303-14.
3. Kaur H, Dhiman S, Sandeep A, Niosomes: A Novel Drug Delivery System, International Journal of Pharmaceutical Sciences. Rev. Res., 2012; 15(1):113-120.
4. Vadlamudi HC, Sevukarajan M, Niosomal Drug Delivery System-A Review, Indo American Journal of Pharmaceutical Research. 2012:2(9).
5. Muzzalupo R, Tavano L, Niosomal Drug Delivery For Transdermal Targeting: Recent Advances, Research And Reports In Transdermal Drug Delivery, 2015:423-33.
6. Rageeb MD. Usman, Ghuge PR, Jain BV, Niosomes: A Novel Trend of Drug Delivery, EJBPS, 2017; 4(7):436-442.
7. Debnath A, Kumar A, Structural And Functional Significance of Niosome And Proniosome In Drug Delivery System, International Journal of Pharmacy And Engineering, 2015; 3(3):621-637.
8. Sankhyan A, Pawar P, Recent Trends In Niosome as Vesicular Drug Delivery System, Journal of Applied Pharmaceutical Science 2012; 02(06):20-32.
9. Rogerson A, The Distribution of Doxorubicin In Mice Following Administration In Niosomes, J Pharm, Pharmacol, 40(5):337-42.
10. Mayer LD, Bally MB, Hope MJ, Cullis PR.,Uptake of Antineoplastic Agents Into Large Unilamellar Vesicles In Response To A Membrane Potential, Biochem Biophys Acta. 1985; 816(2):294-302.
11. Singh G, Dwivedi H, Saraf SK, Saraf SA, Niosomal Delivery of Isoniazid - Development And Characterization, Tropical J Pharm Res. April 2011; 10 (2):203-210.
12. Lohumi A, Rawat S, Sarkar S, Sipai AB, Yadav MV, Review Article A Novel Drug Delivery System: Niosomes Review. J of Drug Delivery & Therapeutics 2012; 2(5):129-135.
13. Madhav NVS, Saini A, Niosomes: A Novel Drug Delivery System, International Journal of Research in Pharmacy and Chemistry. 2011; 1(3).
14. Chandu VP, Arunachalam A, Jeganath S, Yamini K, Tharangini K, Chaitanya G, Niosomes: A Novel Drug Delivery System, International Journal of Novel Trends in Pharmaceutical Sciences, 2012; 2(1).
15. Gurjar P, Naik N, Chouksey S, Niosome: A Promising Pharmaceutical Drug Delivery, Int. J. Pharm Anal, 2(5):425-431.
16. Shakya V, Bansal BK, Niosomes: A Novel Trend In Drug Delivery, International Journal of Research And Development In Pharmacy And Life Sciences, 2014, 3(4):1036-1041.
17. Karim KM, Mandal AS, Biswas N, Guha A, Chatterjee S, Behera M, Kuotsu K, Niosome: A Future of Targeted Drug Delivery Systems Journal Of Advanced Pharmaceutical Technology & Research, 2010; 1(4).
18. Jindal K, Niosomes as A Potential Carrier System: A Review, International Journal of Pharmaceutical, Chemical And Biological Sciences, 2015; 5(4):947-959.
19. Sarker A, Shimu IJ, Alam SAA, Niosome: As Dermal Drug Delivery Tool, IOSR Journal of Pharmacy And Biological Sciences, 2015; 10(2):73-79.
20. Nasir A, Harikumar SL, Kaur A, Niosomes: An Excellent Tool For Drug Delivery, IJRPC 2012; 2(2).
21. Yoshida H, Lehr CM, Kok W, Junginger HE, Verhoef JC, Bouwstra JA, Niosomes for Oral Delivery of Peptide Drugs, Journal of Controlled Release, 1992; 21(1–3):145-153.
22 Dwivedi C., Sahu R., Tiwari S., Satapathy T., Roy A. Role of liposome in novel drug delivery system. Journal of Drug Delivery and Therapeutics, 2014; 4(2):116-129.
23. Biswal S, Murthy PN, Sahu J, Sahoo P, Amir F, Vesicles Of Non-Ionic Surfactants (Niosomes) And Drug Delivery Potential, International Journal Of Pharmaceutical Sciences And Nanotechnology, 2008; 1(1).
24. Rastogi B., Nagaich U., Jain D. Development and characterization of non-ionic surfactant vesicles for ophthalmic drug delivery of diclofenac potassium. Journal of Drug Delivery and Therapeutics, 2014; 1-6.
25. Hunter CA, Dolan TF, Coombs GH, Baillie AJ, Vesicular Systems (Niosomes And Liposomes) For Delivery of Sodium Stibogluconate In Experimental Murine Visceral Leishmaniasis, J Pharm Pharmacol. 1988; 40(3):161-165.
26. Pola Chandu V, Arunachalam A, Jeganath S, Yamini K, Tharangini K, Chaitanya G, Niosomes: A Novel Drug Delivery System, International Journal of Novel Trends In Pharmaceutical Sciences, 2012; 2(1).
27. Tangri P, Khurana S, Niosomes: Formulation and Evaluation, International Journal Of Biopharmaceutics. 2011; 2(1):47-53.
28. Jaiswal P., Kesharwani S., Kesharwani R., Patel D. Ethosome: a new technology used as topical & transdermal delivery system. Journal of Drug Delivery and Therapeutics, 2016; 6(3):7-17
29. Keservani RK, Sharma AK, Ayaz MD, Novel Drug Delivery System For The Vesicular Delivery of Drug By The Niosomes, International Journal of Research in Controlled Release 2011; 1(1):1-8.
30. Vishvakrama P., Sharma S. Liposomes: an overview. Journal of Drug Delivery and Therapeutics, 2014; 47-55.
31. Tangri P, Khurana S, Niosomes: Formulation and Evaluation, International Journal Of Biopharmaceutics. 2011; 2(1):47-53.
32. Kumari R., Verma K., Verma A., Yadav G., Maurya S. Proniosomes: a key to improved drug delivery. Journal of Drug Delivery and Therapeutics, 2014; 56-65.
33. Shalin C, Swathi P Nair, Shijila P, Effect of Surfactants And Cholesterol On Physical Properties of BCS Class 2 Drug Loaded Niosomes, International Journal of Applied Pharmaceutical And Biological Research, 2017; 2(6):8-14.
34. Suma U S, Parthiban S, Senthil Kumar GP, Tamiz Mani T, Novelty of Niosomal Gel In Tdds Application, Asian Journal Of Research In Biological And Pharmaceutical Sciences. 2015; 3(2):41-48.
35. Srivastava NS, Thakur S, Kaur J, Niosomes: A Novel Approach for Topical Delivery of Drugs, IJPT 2016; 8(2):11712-11731.
36. Gopalakrishnan S, Chenthilnathan A, Niosomes – A Novel Drug Delivery Device, Research Journal of Pharmaceutical, Biological And Chemical, 2012; 3(3):1090.
37. Pei Ling Yeo, Chooi Ling Lim, Soi Moi Chye, Anna Pick Kiong Ling, Rhun Yian Koh, Niosomes: A Review Of Their Structure, Properties, Methods Of Preparation, And Medical Applications, Asian Biomed (Res Rev News) 2017; 11(4):301–14
38. Singh S, Niosomes: A Role In Targeted Drug Delivery System, IJPSR, 2013; 4(2):550-557.
38. Sharma BS, Bhogale V, Adepu AR, Patil ST, Sangha SK, Proniosomes : A Novel Provesicular Drug Delivery System, International Journal For Pharmaceutical Research Scholars, 2015; 4(2).
40. Gadhiya P, Shukla S, Modi D, Bharadia P, Niosomes In Targeted Drug Delivery – A Review, International Journal For Pharmaceutical Research Scholars, 2012; 1(2).
40. Patel SM, Rathod DR, Patel KN, Patel BA, Patel PA, Niosome As An Effective Drug Delivery: A Review, International Journal For Pharmaceutical Research Scholars (IJPRS), 2012; 1(2).
42. Verma NK, Roshan A, Niosomes and Its Application-A Review, IJRPLS, 2014; 2(1):182-184.
43. Gupta R, Kumar S, Gupta N, Anurag Kumar, The New Advancement Nanotechnology: Proniosomes As A Promising And Potential Drug Carrier, International Journal of Research And Development In Pharmacy And Life Sciences, October - November, 2014; 3(6):1258-1265.
44. Khindri S, Aggarwal S, Hari Kumar SL , Role of Niosomes And Proniosomes For Enhancing Bioavailability of Drugs, Journal of Drug Delivery AND Therapeutics. 2015; 5(1):28-33
45. Kalra NG. Jeyabalan, Singh G, Choudhary S, Non-Ionic Surfactant Vesicles and Their Therapeutics Potentials, JIPBS, 2016; 3(2):193-201.
2. Handjani-Vila RM, Dispersion of Lamellar Phases of Nonionic Lipids In Cosmetic Products, Int J Cosmetic Sci, 1979; 1(5):303-14.
3. Kaur H, Dhiman S, Sandeep A, Niosomes: A Novel Drug Delivery System, International Journal of Pharmaceutical Sciences. Rev. Res., 2012; 15(1):113-120.
4. Vadlamudi HC, Sevukarajan M, Niosomal Drug Delivery System-A Review, Indo American Journal of Pharmaceutical Research. 2012:2(9).
5. Muzzalupo R, Tavano L, Niosomal Drug Delivery For Transdermal Targeting: Recent Advances, Research And Reports In Transdermal Drug Delivery, 2015:423-33.
6. Rageeb MD. Usman, Ghuge PR, Jain BV, Niosomes: A Novel Trend of Drug Delivery, EJBPS, 2017; 4(7):436-442.
7. Debnath A, Kumar A, Structural And Functional Significance of Niosome And Proniosome In Drug Delivery System, International Journal of Pharmacy And Engineering, 2015; 3(3):621-637.
8. Sankhyan A, Pawar P, Recent Trends In Niosome as Vesicular Drug Delivery System, Journal of Applied Pharmaceutical Science 2012; 02(06):20-32.
9. Rogerson A, The Distribution of Doxorubicin In Mice Following Administration In Niosomes, J Pharm, Pharmacol, 40(5):337-42.
10. Mayer LD, Bally MB, Hope MJ, Cullis PR.,Uptake of Antineoplastic Agents Into Large Unilamellar Vesicles In Response To A Membrane Potential, Biochem Biophys Acta. 1985; 816(2):294-302.
11. Singh G, Dwivedi H, Saraf SK, Saraf SA, Niosomal Delivery of Isoniazid - Development And Characterization, Tropical J Pharm Res. April 2011; 10 (2):203-210.
12. Lohumi A, Rawat S, Sarkar S, Sipai AB, Yadav MV, Review Article A Novel Drug Delivery System: Niosomes Review. J of Drug Delivery & Therapeutics 2012; 2(5):129-135.
13. Madhav NVS, Saini A, Niosomes: A Novel Drug Delivery System, International Journal of Research in Pharmacy and Chemistry. 2011; 1(3).
14. Chandu VP, Arunachalam A, Jeganath S, Yamini K, Tharangini K, Chaitanya G, Niosomes: A Novel Drug Delivery System, International Journal of Novel Trends in Pharmaceutical Sciences, 2012; 2(1).
15. Gurjar P, Naik N, Chouksey S, Niosome: A Promising Pharmaceutical Drug Delivery, Int. J. Pharm Anal, 2(5):425-431.
16. Shakya V, Bansal BK, Niosomes: A Novel Trend In Drug Delivery, International Journal of Research And Development In Pharmacy And Life Sciences, 2014, 3(4):1036-1041.
17. Karim KM, Mandal AS, Biswas N, Guha A, Chatterjee S, Behera M, Kuotsu K, Niosome: A Future of Targeted Drug Delivery Systems Journal Of Advanced Pharmaceutical Technology & Research, 2010; 1(4).
18. Jindal K, Niosomes as A Potential Carrier System: A Review, International Journal of Pharmaceutical, Chemical And Biological Sciences, 2015; 5(4):947-959.
19. Sarker A, Shimu IJ, Alam SAA, Niosome: As Dermal Drug Delivery Tool, IOSR Journal of Pharmacy And Biological Sciences, 2015; 10(2):73-79.
20. Nasir A, Harikumar SL, Kaur A, Niosomes: An Excellent Tool For Drug Delivery, IJRPC 2012; 2(2).
21. Yoshida H, Lehr CM, Kok W, Junginger HE, Verhoef JC, Bouwstra JA, Niosomes for Oral Delivery of Peptide Drugs, Journal of Controlled Release, 1992; 21(1–3):145-153.
22 Dwivedi C., Sahu R., Tiwari S., Satapathy T., Roy A. Role of liposome in novel drug delivery system. Journal of Drug Delivery and Therapeutics, 2014; 4(2):116-129.
23. Biswal S, Murthy PN, Sahu J, Sahoo P, Amir F, Vesicles Of Non-Ionic Surfactants (Niosomes) And Drug Delivery Potential, International Journal Of Pharmaceutical Sciences And Nanotechnology, 2008; 1(1).
24. Rastogi B., Nagaich U., Jain D. Development and characterization of non-ionic surfactant vesicles for ophthalmic drug delivery of diclofenac potassium. Journal of Drug Delivery and Therapeutics, 2014; 1-6.
25. Hunter CA, Dolan TF, Coombs GH, Baillie AJ, Vesicular Systems (Niosomes And Liposomes) For Delivery of Sodium Stibogluconate In Experimental Murine Visceral Leishmaniasis, J Pharm Pharmacol. 1988; 40(3):161-165.
26. Pola Chandu V, Arunachalam A, Jeganath S, Yamini K, Tharangini K, Chaitanya G, Niosomes: A Novel Drug Delivery System, International Journal of Novel Trends In Pharmaceutical Sciences, 2012; 2(1).
27. Tangri P, Khurana S, Niosomes: Formulation and Evaluation, International Journal Of Biopharmaceutics. 2011; 2(1):47-53.
28. Jaiswal P., Kesharwani S., Kesharwani R., Patel D. Ethosome: a new technology used as topical & transdermal delivery system. Journal of Drug Delivery and Therapeutics, 2016; 6(3):7-17
29. Keservani RK, Sharma AK, Ayaz MD, Novel Drug Delivery System For The Vesicular Delivery of Drug By The Niosomes, International Journal of Research in Controlled Release 2011; 1(1):1-8.
30. Vishvakrama P., Sharma S. Liposomes: an overview. Journal of Drug Delivery and Therapeutics, 2014; 47-55.
31. Tangri P, Khurana S, Niosomes: Formulation and Evaluation, International Journal Of Biopharmaceutics. 2011; 2(1):47-53.
32. Kumari R., Verma K., Verma A., Yadav G., Maurya S. Proniosomes: a key to improved drug delivery. Journal of Drug Delivery and Therapeutics, 2014; 56-65.
33. Shalin C, Swathi P Nair, Shijila P, Effect of Surfactants And Cholesterol On Physical Properties of BCS Class 2 Drug Loaded Niosomes, International Journal of Applied Pharmaceutical And Biological Research, 2017; 2(6):8-14.
34. Suma U S, Parthiban S, Senthil Kumar GP, Tamiz Mani T, Novelty of Niosomal Gel In Tdds Application, Asian Journal Of Research In Biological And Pharmaceutical Sciences. 2015; 3(2):41-48.
35. Srivastava NS, Thakur S, Kaur J, Niosomes: A Novel Approach for Topical Delivery of Drugs, IJPT 2016; 8(2):11712-11731.
36. Gopalakrishnan S, Chenthilnathan A, Niosomes – A Novel Drug Delivery Device, Research Journal of Pharmaceutical, Biological And Chemical, 2012; 3(3):1090.
37. Pei Ling Yeo, Chooi Ling Lim, Soi Moi Chye, Anna Pick Kiong Ling, Rhun Yian Koh, Niosomes: A Review Of Their Structure, Properties, Methods Of Preparation, And Medical Applications, Asian Biomed (Res Rev News) 2017; 11(4):301–14
38. Singh S, Niosomes: A Role In Targeted Drug Delivery System, IJPSR, 2013; 4(2):550-557.
38. Sharma BS, Bhogale V, Adepu AR, Patil ST, Sangha SK, Proniosomes : A Novel Provesicular Drug Delivery System, International Journal For Pharmaceutical Research Scholars, 2015; 4(2).
40. Gadhiya P, Shukla S, Modi D, Bharadia P, Niosomes In Targeted Drug Delivery – A Review, International Journal For Pharmaceutical Research Scholars, 2012; 1(2).
40. Patel SM, Rathod DR, Patel KN, Patel BA, Patel PA, Niosome As An Effective Drug Delivery: A Review, International Journal For Pharmaceutical Research Scholars (IJPRS), 2012; 1(2).
42. Verma NK, Roshan A, Niosomes and Its Application-A Review, IJRPLS, 2014; 2(1):182-184.
43. Gupta R, Kumar S, Gupta N, Anurag Kumar, The New Advancement Nanotechnology: Proniosomes As A Promising And Potential Drug Carrier, International Journal of Research And Development In Pharmacy And Life Sciences, October - November, 2014; 3(6):1258-1265.
44. Khindri S, Aggarwal S, Hari Kumar SL , Role of Niosomes And Proniosomes For Enhancing Bioavailability of Drugs, Journal of Drug Delivery AND Therapeutics. 2015; 5(1):28-33
45. Kalra NG. Jeyabalan, Singh G, Choudhary S, Non-Ionic Surfactant Vesicles and Their Therapeutics Potentials, JIPBS, 2016; 3(2):193-201.
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Kaur D, Kumar S. NIOSOMES: PRESENT SCENARIO AND FUTURE ASPECTS. JDDT [Internet]. 6Sep.2018 [cited 2Feb.2023];8(5):35-3. Available from: http://www.jddtonline.info/index.php/jddt/article/view/1886
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