Antinociceptive, Anti-Inflammatory and Antidepressant potential of methanolic extract of Celosia argentea Linn
Abstract
The present study was done to determine the antinociceptive, anti-inflammatory and antidepressant activity of methanolic extract of leaves of Celosaia argentea (MECA) by oral administration at doses of 100, 200 and 400 mg/kg/day of body weight to healthy swiss albino mice. The MECA was studied for antinociceptive effect using Eddy’s hot plate method and tail flick method in albino mice and anti-inflammatory effect by using carrageenan-induced hind paw edema in mice and the mean increase in paw volume and % inhibition in paw volume was measured plethysmometer at different time intervals after carrageenan injection (1% w/v). The MECA was evaluated for antidepressant effect using forced swim and tail suspension methods in albino mice. The MECA showed antinociceptive effect evidenced by the increase in the reaction time by Eddy’s hot plate method and tail flick method in albino mice and anti-inflammatory effect by significant (P<0.001) reduction in the carrageenan-induced paw edema in mice. The MECA showed a significant antinociceptive, anti-inflammatory and antidepressant effect when compared with the standard drugs viz pentazocine, indomethacin and imipramine respectively. The present observation indicated significant (P<0.001) activity of the methanolic extract of Celosia argentea in the treatment of pain, inflammation, and depression.
DOI
https://doi.org/10.22270/jddt.v9i2-s.2700References
Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. 5th ed. New Delhi India:Elsevier Science Ltd; 2011. P.318-335.
Sosa S, Balick M, Arvigo R, Esposito R, Pizza C, Altinier G, A Screening of the topical Anti-inflammatory activity of some Central American plants, Journal of Ethnopharmacology, 2002; (8):211-215.
Mitchell R, Cotran R. In Robinson’s basic pathology, 7th ed. New Delhi: Harcourt (India) Pvt. Ltd; 2003. P.33.
Ashok Kumar BS, Lakshman K, Velmurugan C, Sridhar SM, Gopisetty S, Antidepressant activity of methanolic extract of Amaranthus spinosus, Basic Clinical Neuroscience, 2014; 5(1):11-7.
Kirtikar K, Basu B. Indian Medicinal Plant. 2nd ed., Dehradun:Interanational Book Distributors, Dehradun; 1999. P. 354-360.
Thangarasu V, Manuiappan J, Bangaru A, Antidiabetic activity of alcoholic extract of Celosia argentea Linn. seeds in rats, Biological Pharmaceutical Bulletin, 2002; 25:526-528.
Shan JJ, Ren JW, Yang J, Zhao YM, Hypoglycemic effect of Celosia argentea fractions in alloxan-induced diabetic mice, China Pharmaceutical Journal, 2005; 40.
Bhujbal S, Patil K, Patil M, Evaluation of Antipyretic potentials of Celosia argentea Linn leaf extract, Planta Indica, 2006; 2:19-20.
Rub RA, Patil MJ, Ghorpade P, Siddiqui A, Evaluation of antioxidant potential of Celosia argentea extracts, Pharmacognosy Journal, 2013; 5:140–141.
Molehin OR, Adefegha SA, Oboh G, Saliu JA, Athayde ML, Boligon AA, Comparative study on the phenolic content, antioxidant properties and HPLC fingerprinting of three varieties of Celosia species, Journal of Food Biochemistry, 2014; 38:575–583.
Patel K, Shah M, Contribution to Indigenous Drugs Part-I Celosia argentea. International Journal of Pharmacognosy, 1993; 31(3):223-234.
Patil K, Bhujbal S, Chaturvedi S, Anti-inflammatory activity of various extracts Celosia argentea Linn., Indian Journal of Pharmaceutical Science 2003; 645-647.
Hase K, Basnet P, Kadota S, Namba T, Immunostimulating activity of celosian, an antihepatotoxic polysaccharide isolated from Celosia argentea. Planta Medica, 1997; 63:216–219.
Wu QB, Wang Y, Liang L, Jiang Q, Guo ML, Zhang JJ, Novel triterpenoid saponins from the seeds of Celosia argentea L., Natural Product Research, 2013; 27:1353–1360.
Sharma P, Vidyasagar G, Singh S, Ghule S, Kumar B, Antidiarrhoeal activity of leaf extract of Celosia argentea in experimentally induced diarrhea in rats, Journal of Advance Pharmaceutical Technology Research 2010; 1:41–48.
Hayakawa Y, Fujii H, Hase K, Ohnishi Y, Sakukawa R, Kadota S, Namba T, Saiki I. Anti-metastatic and immunomodulating properties of the water extract from Celosia argentea seeds. Biol. Pharm. Bull. 1998; 21:1154–1159.
Wu Q, Wang Y, Guo M. Triterpenoid saponins from the seeds of Celosia argentea and their anti-inflammatory and antitumor activities. Chem. Pharm. Bull. 2011; 59:666–671.
Devhare SV, Nirmal SA, Rub RA, Dhasade VV, Zaware BB, Mandal SC. Immunomodulating activity of Celosia argentea Linn aerial plants. Latin Amercan Journal of Pharmacy, 2011; 30(1):168-71
Chi X, Guo ML, Song H, Chen YD. Study on chemical constituents of Celosia cristata seed, Journal of Jilin Agricultural University, 2010; 32:657–660.
Tang Y, Xin HL, Guo ML, Review on research of the phytochemistry and pharmacological activities of Celosia argentea, Revista Brasileira de Farmacognosia. 2016; 26:787-796.
OECD. OECD No 423, Acute oral toxicity- Acute toxic class method, The Organization for Economic Co-operation and Development (OECD) Guidelines for the testing of chemicals. adopted by the council on 17th December, 2001.
Turner R. Screening methods in pharmacology. Academic Press, New York, 1965. P. 100.
Choi Eun-Mi, Hwang Jae-Kwan, Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare, Fitoterapia, 2004; 75:557–565.
Venkatesa P, Adiraj M, Shanmuga P, Synthesis, analgesic and anti-inflammatory evaluation of substituted 4- piperidones, Indian Drugs, 2001; 38:156.
Goyal M, Ghosh M, Nagori B, Sasmal D, Analgesic and anti-inflammatory studies of cyclopeptide alkaloid fraction of leaves of Ziziphus nummularia, Saudi Journal of Biological Sciences, 2013; 20:365–371
Porsolt RD, Bertin A, Blavet N, Deniel M, Jalfre M, Behavioral despair in mice: a primary screening test for antidepressants, Archives International de Pharmacodynamic et de Therapie,1977; 229:326-27.
Steru L, Chermat R, Thierry B, Simon P, TST: a new method for screening antidepressants in mice, Psychopharmacology. 1985; 85:367-370.
Annamalai P, Khosa R, Hemalatha S. Evaluation of analgesic potential of Solanum trilobatum roots, International journal of pharmaceutical research, 2009; 8(4): 269-273.
Antonisamy P, Dhanasekaran M, Kim H, Jo S, Agastian P, Kwon K, Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models, Saudi Journal of Biological Sciences, 2017; 24:1933-1938.
Bhujbal SS, Chitlange SS, Surulkar AA, Shinde DB, Patil MJ, Antiinflammatory activity of an isolated fraction from celosia argentea Linn., Journal of medicinal plants research, 2008; 2(3):052-054.
Ashok Kumar BS, Lakshman K, Velmurugan C, Sridhar SC, Gopisetty S, Antidepressant activity of Methanolic extract of Amaranthus Spinousus, Basic clinical Neuroscience, 2014; 5(1):11-17.
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