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Open Access Full Text Article   Review Article

Critical Analytical Review of Charkokta Jwarahara Mahakashay: Classical Foundations and Contemporary Pharmacological Correlation

Dr. Prasenjit K. More ¹, Dr. Smita Rai ²*, Dr. Suwarna A. Meshram ³

¹ Final Year PG Scholar, Department of Dravyaguna Vigyan, Parul Institute of Ayurved and Research, Parul University, Vadodara, Gujarat-391760.

² Assistant Professor, Department of Dravyaguna Vigyan, Parul Institute of Ayurved and Research, Parul University, Vadodara, Gujarat-391760.

³ Prof. & HOD, Department of Dravyaguna Vigyan, Parul Institute of Ayurved and Research, Parul University, Vadodara, Gujarat-391760.

 

 

Introduction

Ayurveda, the ancient medical science of India, is founded on the principle of maintaining harmony among the doshas, Dhatus, Mala, and agni to sustain health.¹ Diseases arise when this equilibrium is disturbed, and among all pathological entities described in classical literature², Jwara is accorded paramount importance. It is often referred to as the "king of diseases" because of its profound capacity to disrupt systemic homeostasis.³ Unlike the modern biomedical definition that confines fever to the elevation of body temperature, Ayurveda conceptualizes Jwara as a complex pathological process affecting Deha (body), Indriya (sense organ), and Mana (mind).⁴

According to classical understanding, Jwara originates when vitiated Doshas, predominantly Pitta, combine with Ama formed due to Mandagni.⁵ This combination occurs in the Amashaya and leads to obstruction of the Rasavaha and Swedavaha Strotas.^6-8 As a consequence, Agni is displaced from its normal physiological location, resulting in systemic heat manifestation characterized by Santapa, Aruchi, Trishna, Angamarda, and Generalized malaise.^9,10 The blockage of sweat channels further prevents proper heat dissipation, intensifying the febrile state. Therefore, Jwara is not merely hyperthermia but a systemic inflammatory-metabolic disorder requiring multidimensional therapeutic intervention.¹¹

Acharya Charaka systematically classified drugs into fifty Mahakashaya¹² based on similarity in action. Among these, Jwarahara Mahakashaya¹³ comprises ten specific drugs grouped for their antipyretic potential. The rationale behind selecting these particular drugs suggests a sophisticated understanding of stage-specific disease management. The present review aims to explore the classical foundations and modern correlations to elucidate the probable integrated mechanism of this Mahakashaya in the management of Jwara. 

Material and Methodology

The present work is a comprehensive literary and analytical review conducted in accordance with classical Ayurvedic research methodology. Primary references were drawn from the Brihattrayi, including the Charaka Samhita, Sushruta Samhita, and Ashtanga Hridaya, along with authoritative Nighantus such as Dhanvantari Nighantu, Madanpala Nighantu, Kaideva Nighantu, Bhavprakasha Nighantu, and Raj Nighantu. The methodological framework involved systemic evaluation of each of the ten drugs under defined parameters, including classical categorization, Rasapanchaka, Dosha Karma, botanical classification, phytochemical composition, pharmacological activities, and therapeutic indications.

In addition to classical sources, contemporary scientific literature was reviewed through published research articles focusing on phytochemistry, pharmacological, antimicrobial studies, antipyretic models, and immunomodulatory investigations. A comparative and critical analytical approach was adopted to correlate Ayurvedic pharmacodynamic principles with experimentally validated biomedical evidence. The discussion was structured to integrate classical interpretations with modern findings to derive a coherent understanding of the therapeutic design of Jwarahara mahakashaya.

Conceptual Understanding of Jwara and Therapeutic Requirements

In Ayurvedic nosology, Jwara is broadly classified into sama and nirama types.¹⁴ Sama Jwara is characterized by the presence of Ama, Mandagni, heaviness, coated tongue, and low-grade fever.¹⁵ Nirama Jwara typically manifests after the digestion of Ama, presenting with clearer symptoms and a relatively higher temperature.¹⁶ This staging implies that treatment must be dynamic and stage-specific rather than uniform. 

From a therapeutic standpoint, drugs used in Jwara must fulfill multiple roles. They should possess Deepana and Pachana properties to digest Ama,^17,18 Strotoshodhana action to clear obstructed channels, Pittashamana properties to reduce excessive heat, and Rasayana effect to restore vitality and immunity.¹⁹ The intelligent grouping of ten drugs in Jwarahara mahakashaya reflects fulfillment of these multidimensional requirements.

Pharmacodynamic Analysis of Jwarahara Mahakashaya

An in-depth evaluation of Rasapanchaka reveals that the majority of drugs in this group possess Madhura rasa and Madhura vipaka, both of which are known for Vatapittashamana properties and Dhatu nourishment.^20,21 Sheeta Virya drugs such as Draksha, Amalaki, Sariva, Parushaka, and Sharkara exhibit cooling properties that pacify aggravated Pitta and are particularly beneficial in Nirama or acute febrile conditions. These drugs help reduce hyperthermia, soothe inflamed tissues, and prevent excessive catabolism.

Contrarily, Ushna Virya drugs, including Abhaya, Vibhitaki, Manjishtha, Patha, and Peelu, demonstrate Deepana-Pachana action, promoting Ama digestion and alleviating Kapha-induced Strotorodha. In Sama Jwara, where Ama predominates, these drugs facilitate metabolic correction by restoring Agni and clearing microchannel obstruction. Katu Rasa and Katu Vipaka, present in certain drugs, contribute to Lekhana and Shoshana Karma, aiding in the removal of metabolic toxins.^22-23

The coexistence of Sheeta and Ushna Virya drugs in a single Mahakashaya illustrates an advanced understanding of disease staging and individualized therapeutic approach. 

 

 

Table 1: Showing Rasa, Guna, Virya, Vipaka, and Dosha Karma of the Dravyas of Jwarahara Mahakashay^24-33

Dravya	Rasa	Guna	Virya	Vipaka	Dosha Karma
Draksha	Madhura, Kashaya	Guru, Sara, Snigdha	Sheeta	Madhura	Vatapittahara
Abhaya	Kashay, Madhura, Amla, Katu, Tikta	Laghu, Ruksha	Ushna	Madhura	Vatanulomana
Amalaka	Madhura, Amla, Katu, Tikta, Kashaya	Laghu, Ruksha	Sheeta	Madhura	Tridoshahara
Vibhitak	Katu, Kashaya Tikta,	Laghu, Ruksha	Ushna	Katu	Kaphapittahara
Sariva	Madhura, Tikta	Guru, Snigdha	Sheeta	Madhura	Kaphavatasha maka
Manjishtha	Madhura, Tikta, Kashaya	Guru, Snigdha	Ushna	Madhura	Kaphashamaka
Patha	Katu, Tikta	Guru, Teekshna	Ushna	Katu	Kapha Pitta Shamaka and Vata Kaphahara
Parushaka	Amla, Madhura (Pakva), Kashaya (Apakva)	Guru, Ruksha	Sheeta	Katu	Vata Shamaka, Vatapittashamaka (Pakva)
Peelu	Madhura, Amla, Katu, Tikta, Kashaya	Snigdha, Lagu, Teekshna, Kinchit Ruksha	Ushna	Katu	Kaphavata Shamaka
Sharkara	Madhura	Susheeta, Swabhavata Hitkara	Sheeta	Madhura	Vatapittahara

 

 

Table 2: Showing Pharmacological actions of Jwarahara Mahakashaya drugs^34-43

Dravya	Latin name	Family	Part used	Pharmacological actions
Draksha	Vitis vinifera	Vitaceae	Fruit	Antioxidant, antibacterial, anti-histaminic34
Abhaya	Terminalia chebula	Comrebtaceae	Fruit, seed	Cardiac tonic, aphrodisiac, diuretic, anti-phlegmatic, antipyretic35
Amalaka	Emblica officinalis	Euphorbiaceae	Fruit pulp, fruit rind	Anti-microbial, immunomodulatory, anti-inflammatory, antioxidant, anti-tussive36
Vibhitak	Terminal bellerica	Combretaceae	Fruit rind, seed, kernel	Antioxidant, antimicrobial, antidiarrheal, anticancer, antihypertensive, hepatoprotective, antipyretic37
Sariva	Hemidesmus indicus	Asclepidaceae	Root	Antimicrobial, anti-carcinogenic, cytotoxic potential38
Manjishtha	Rubia cordifolia	Rubiaceae	Root, stem	Hypoglycemic activity, anticancer, effectiveness in wound healing, antiproliferative activity, hepatoprotective39
Patha	Cissampelos pareira	Menispermaceae	Root, stem	Anti-microbial, antifertility, diuretic40
Parushaka	Grewia asiatica	Tiliaceae	Fruit, leaf, root	Anti-rheumatic, carminative, digestive, astringent, cooling, diuretic, antimicrobial, anthelmintic, antiviral, antipyretic, anti-inflammatory, antifertility, hypoglycemic41
Peelu	Salvadora persica	Salvadoraceae	Fruit, seed, leaf, root bark	Anti-microbial, anti-cancerous42
Sharkara	Saccharum officinarum	Poaceae	Stem	Anti-cough, anti-asthma, anti-oxidant, cholesterol-lowering, diuretic, anti-inflammatory, antithrombotic, hypocholesterolemia43

 

Table 3: Represents the Chemical composition of Jwarahara Mahakashay drugs

Dravya	Chemical composition
Draksha44	Flavonoids, quercetin, rutin, kaempferol, luteolin, phenolic acid, beta sitosterol
Abhaya45	Chebulinic acid, corilagin, chebulin, and antioxidants like pyrogallol, ferulic, vanillic, phloroglucinol, palmitic acid, and oleic acid
Amalaka46	Tannins, alkaloids, phenolic acids, amino acids, carbohydrates, vitamin c, 3-ethyl gallic acid
Vibhitak47	Tannins, ellagic acid, ethyl gallate, galloyl glucose, chebulagic acid, phyllembin, beta sitosterol, mannitol, glucose, fructose, rhamnose
Sariva48	Hyperoside, rutin desinine, hexatriacontance, beta sitosterol, hemidesminine, hemidesmin 1, hemidesmin 2
Manjishtha49	Yellow gencoside, mangistin, garancin, algerin, zenthgin, salt contents, and a rich amount of starch
Patha50	Hayatin, hayatinin, menismine, cissamine, pareine, cycleanine, babeerine, quercitol
Parushaka51	Bamyrin, betulin, lupeol, glycosides like pelargonidin, delphinine, cyanidin
Peelu52	Gamma monoclinic sulphur, salvadourea,manisic acid, sitosterol, benzyl isothiocyanate, myristic, lauric, palmitic acid
Sharkara53	Sterols, policosanols, phenolic acid, flavonoids, glycosides

 

 

 

 

 

Discussion

The present analytical discussion integrates the methodological framework and classical pharmacodynamic interpretation with modern scientific evidence. The classical categorization of these ten drugs under Jwarahara Mahakashaya reflects a thoughtful and strategic grouping based on similarity in therapeutic action rather than superficial attributes. Synonym analysis across major Nighantus reveals that many alternative names describe morphological features, habitats, or pharmacological functions, providing deeper insight into their intended use. For instance, Abhaya is often referred to as Pathya, denoting its wholesome, channel-clearing properties, while Manjishtha’s synonyms indicate its blood-purifying and Strotoshodhaka properties. Such terminological nuances highlight the functional basis of drug selection.

Rasapanchaka evaluation demonstrates a predominance of Madhura Rasa and Madhura Vipaka, signifying tissue nourishment and Pitta pacification. The balanced inclusion of Sheeta and Ushna Virya drugs suggests therapeutic adaptability in different stages of Jwara. In the Ama-dominant states, Ushna Virya drugs digest metabolic toxins, alleviate Kapha obstruction, and restore Agni. As the disease progresses into the Nirama stage and Pitta dominance, Sheeta Virya drugs mitigate inflammatory heat and preserve Dhatu integrity.⁴⁹ This dynamic stage-wise approach reflects an advanced understanding of disease progression.

Botanical and phytochemical evaluation further substantiates the classical rationale. Draksha (Vitis vinifera) contains flavonoids and resveratrol, which have antioxidant and antimicrobial properties. Amalaki (Phyllanthus emblica) is rich in ascorbic acid and polyphenols and exhibits immunomodulatory and anti-inflammatory effects. Vibhitaki (Terminalia bellerica) has shown antipyretic activity in experimental fever models. Manjishtha (Rubia cordifolia) exhibits antiviral and antibacterial actions due to anthraquinone derivatives. Peelu (Salvadora persica) contains benzyl isothiocyanate, which exhibits antiviral activity. These pharmacological findings indicate that the Mahakashaya does not merely suppress temperature but addresses infectious etiologies, inflammatory mediators, oxidative stress, and immune dysregulation.

From a mechanistic perspective, Jwarahara Mahakashaya appears to function through Ama Pachana, Strotoshodhana, Pittashamana, Vatanulomana, and Rasayana effects. Modern biomedical interpretation suggests possible modulation of prostaglandin pathways involved in hypothalamic temperature regulation, along with inhibition of microbial proliferation and reduced inflammatory cytokine production. The antioxidant properties protect tissues from oxidative damage during febrile states, while immunomodulatory actions enhance host defense mechanisms. Thus, the classical grouping aligns closely with contemporary understanding of fever as a systemic inflammatory and immune-mediated response.

Conclusion

Jwarahara Mahakashaya, as described in the Charak Samhita, represents a rational and therapeutically strategic grouping of ten drugs designed for comprehensive management of Jwara. The balanced presence of Ushna and Sheeta Virya substances ensures stage-specific intervention in both Sama and Nirama conditions, while the predominance of Madhura Vipaka supports metabolic stability and tissue nourishment. Classical Rasapanchaka principles correlate meaningfully with modern evidence demonstrating antipyretic, antimicrobial, anti-inflammatory, antioxidant, and immunomodulatory activities. Thus, Jwarahara Mahakashaya reflects a holistic, pathogenesis-oriented approach to fever management and holds significant potential for evidence-based integration into contemporary practice. 

References

1. Shastri AD. Susruta Samhita of Maharshi Susruta. Varanasi: Chaukhamba Sanskrit Pratishthan; 2010. p.64:15/58. 
2. Sharma PV. Ashtanga Hridayam. Varanasi: Chaukhamba Orientalia; 2016. Sutrasthana, Ch.1, Ver.21, p.15. 
3. Amale DJ, Ban KK. Conceptual study of Jwara Aam, Pachayamana, Nirama Avastha with reference to CRP levels. J Pharmacogn Phytochem. 2024;13(5):559–61. doi: https://dx.doi.org/10.22271/phyto.2024.v13.i5h.15126.    
4. Acharya YJT. Charaka Samhita by Agnivesha. New Delhi: Chaukhambha Publication; 2017. Chikitsasthana, Ch.3, Ver.4, p.398. 
5. Acharya YJT. Charaka Samhita by Agnivesha. New Delhi: Chaukhambha Publication; 2017. Nidanasthana, Ch.1, Ver.20, p.199. 
6. Vijayrakshit S. Madhava Nidana of Madhavkara. Varanasi: Chaukhambha Sanskrit Sansthan; 2012. Jwaranidanam, Ver.2, p.21. 
7. Acharya YJT. Charaka Samhita by Agnivesha. New Delhi: Chaukhambha Publication; 2017. Sutrasthana, Ch.28, Ver.9, p.179. 
8. Acharya YJT. Charaka Samhita by Agnivesha. New Delhi: Chaukhambha Publication; 2017. Vimanasthana, Ch.5, Ver.8, p.251. 
9. Vijayrakshit S. Madhava Nidana of Madhavkara. Varanasi: Chaukhambha Sanskrit Sansthan; 2012. Jwaranidanam, Ver.3, p.22. 
10. Acharya VJT. Sushruta Samhita. Varanasi: Chaukhambha Sanskrit Sansthan; 2019. Uttartantra, Ch.39, Ver.13, p.671. 
11. Singh J. The comprehensive Ayurvedic management of Jwara (fever): an evidence-based narrative review. Int J Res Sci Innov. 2025;12(6):806–13. doi: https://dx.doi.org/10.51244/ijrsi.2025.12060064.  
12. Acharya YJT. Charaka Samhita by Agnivesha. New Delhi: Chaukhambha Publication; 2017. Sutrasthana, Ch.4, Ver.8, p.31. 
13. Acharya YJT. Charaka Samhita by Agnivesha. New Delhi: Chaukhambha Publication; 2017. Sutrasthana, Ch.4, Ver.16, p.34. 
14. Vijayrakshit S. Madhava Nidana of Madhavkara. Varanasi: Chaukhambha Sanskrit Sansthan; 2012. Jwaranidanam, Ver.60, p.45. 
15. Vijayrakshit S. Madhava Nidana of Madhavkara. Varanasi: Chaukhambha Sanskrit Sansthan; 2012. Jwaranidanam, Ver.61–63, p.45. 
16. Vijayrakshit S. Madhava Nidana of Madhavkara. Varanasi: Chaukhambha Sanskrit Sansthan; 2012. Jwaranidanam, Ver.65, p.46. 
17. Acharya YJT. Charaka Samhita by Agnivesha. New Delhi: Chaukhambha Publication; 2017. Chikitsasthana, Ch.3, Ver.142, p.409. 
18. Sharangdharacharya. Sharangdhara Samhita. Varanasi: Chaukhambha Surbharati Prakashan; 2012. Poorvakhanda, Ch.4, Ver.2, p.43. 
19. Harivedi R. Rasayana therapy in Ayurveda: a key to preventing lifestyle disorders and promoting longevity. J Ayurveda Integr Med Sci. 2025;10(2):291–4. doi: https://dx.doi.org/10.21760/jaims.10.2.41.  
20. Acharya YJT. Charaka Samhita by Agnivesha. New Delhi: Chaukhambha Publication; 2017. Sutrasthana, Ch.26, Ver.43(1), p.144. 
21. Sirigoud LS, Shinde YB, Sharma A, Thakare M, Shirke U. A novel approach of Ayurveda towards understanding the fundamental characteristics and health benefits of various types of takras (buttermilk). Int J Ayurveda Pharma Res. 2022;10(3):113–118. doi: https://dx.doi.org/10.47070/ijapr.v10i3.2275. 
22. Acharya YJT. Charaka Samhita by Agnivesha. New Delhi: Chaukhambha Publication; 2017. Sutrasthana, Ch.26, Ver.43(5), p.145. 
23. Shah SA, Yeola GH, Mohite P, Shah AP, Swami SI, Jha DH. Controlled clinical study of Mehamudgar Vatika in Prameha with special reference to prediabetes. Res J Pharm Technol. 2025;18(??):606–612. doi: https://dx.doi.org/10.52711/0974-360x.2025.00090. 
24. Chunekar KC. Bhavaprakasha Nighantu. Varanasi: Chaukhambha Bharati Academy; 2010. Aamradiphala Varga, Ver.115–120, p.574. 
25. Chunekar KC. Bhavaprakasha Nighantu. Varanasi: Chaukhambha Bharati Academy; 2010. Haritakyadi Varga, Ver.19–22, p.5. 
26. Chunekar KC. Bhavaprakasha Nighantu. Varanasi: Chaukhambha Bharati Academy; 2010. Haritakyadi Varga, Ver.39–41, p.10. 
27. Chunekar KC. Bhavaprakasha Nighantu. Varanasi: Chaukhambha Bharati Academy; 2010. Aamradiphala Varga, Ver.36–37, p.9. 
28. Chunekar KC. Bhavaprakasha Nighantu. Varanasi: Chaukhambha Bharati Academy; 2010. Guduchyadi Varga, Ver.237, p.411. 
29. Chunekar KC. Bhavaprakasha Nighantu. Varanasi: Chaukhambha Bharati Academy; 2010. Haritakyadi Varga, Ver.190–191, p.107. 
30. Chunekar KC. Bhavaprakasha Nighantu. Varanasi: Chaukhambha Bharati Academy; 2010. Guduchyadi Varga, Ver.192, p.381. 
31. Chunekar KC. Bhavaprakasha Nighantu. Varanasi: Chaukhambha Bharati Academy; 2010. Aamradiphala Varga, Ver.99, p.569. 
32. Chunekar KC. Bhavaprakasha Nighantu. Varanasi: Chaukhambha Bharati Academy; 2010. Aamradiphala Varga, Ver.128, p.578. 
33. Chunekar KC. Bhavaprakasha Nighantu. Varanasi: Chaukhambha Bharati Academy; 2010. Ikshu Varga, Ver.30, p.780. 
34. Nassiri-Asl M, Hosseinzadeh H. Review of the pharmacological effects of Vitis vinifera and its bioactive constituents. Phytother Res. 2016;30(9):1392–403. doi: https://dx.doi.org/10.1002/ptr.5644.  
35. Wang C, Zhang H, Wang X, Li X. Comprehensive review on Terminalia chebula. Molecules. 2024;29(23):5547. doi: https://dx.doi.org/10.3390/molecules29235547.  
36. Variya BC, Bakrania AK, Patel SS. Emblica officinalis: phytochemistry and pharmacology. Pharmacol Res. 2016;111:180–200. doi: https://dx.doi.org/10.1016/j.phrs.2016.06.013.  
37. Zhang XR, Kaunda JS, Zhu HT, Wang D, Yang CR, Zhang YJ. The genus Terminalia: an ethnopharmacological review. Nat Prod Bioprospect. 2019;9(6):357–92. doi: https://dx.doi.org/10.1007/s13659-019-00222-3.  
38. Thakur S, Kaurav H, Chaudhary G. Hemidesmus indicus: a potential traditional plant. Int J Res Ayurveda Pharm. 2021;12(3):106–12. doi: https://dx.doi.org/10.7897/2277-4343.120384.  
39. Shan M, Yu S, Yan H, Chen P, Zhang L, Ding A. Botany and pharmacology of Rubiae Radix. Molecules. 2016;21(12):1747. doi: https://dx.doi.org/10.3390/molecules21121747.  
40. Kumari S, Bhatt V, Suresh PS, Sharma U. Cissampelos pareira: pharmacological review. J Ethnopharmacol. 2021;274:113850. doi: https://dx.doi.org/10.1016/j.jep.2021.113850.  
41. Zia-Ul-Haq M, Stanković M, Rizwan K, Feo V. Grewia asiatica: multiple uses. Molecules. 2013;18(3):2663–82. doi: https://dx.doi.org/10.3390/molecules18032663.  
42. Abhary M, Al-Hazmi AA. Antibacterial activity of Salvadora persica. J Taibah Univ Sci. 2015;10(4):513–20. doi: https://dx.doi.org/10.1016/j.jtusci.2015.09.007.   
43. Gai S, Zhai P. Bioactive compounds in sugarcane. Sugar Tech. 2026. doi: https://dx.doi.org/10.1007/s12355-026-01724-4. 
44. Xia EQ, Deng GF, Guo YJ, Li HB. Biological activities of polyphenols. Int J Mol Sci. 2010;11(2):622–46. doi: https://dx.doi.org/10.3390/ijms11020622.  
45. Bulbul MRH, Chowdhury MNU, Naima TA, Sami SA, Imtiaj MS, Huda N, et al. Review on Terminalia chebula. Heliyon. 2022;8(8):e10220. doi: https://dx.doi.org/10.1016/j.heliyon.2022.e10220.  
46. Variya BC, Bakrania AK, Patel SS. Emblica officinalis: pharmacological review. Pharmacol Res. 2016;111:180–200. doi: https://dx.doi.org/10.1016/j.phrs.2016.06.013.  
47. Kumari S, Jeedigunta M, Joshi A, Agarwal A, Mundkinajeddu D. Pharmacognostic review of Terminalia bellerica. J Pharmacogn Phytochem. 2017;6:368–76. 
48. Mishra G, Chandra HK, Sahu N, Nirala SK, Bhadauria M. Phytochemical screening of Hemidesmus indicus. J Appl Pharm Sci. 2018;8(12):72–9. doi: https://dx.doi.org/10.7324/japs.2018.81210.   
49. Humbare RB, Sarkar J, Kulkarni AA, Juwale MG, Deshmukh SH, Amalnerkar D, et al. Phytochemical characterization of Rubia cordifolia. Antioxidants. 2022;11(5):1006. doi: https://dx.doi.org/10.3390/antiox11051006.   
50. Mendes JWDS, Cunha WEM, Rodrigues FFG, Silveira ER, Lima RDP, Costa JGM. Cissampelos genus: phytochemical aspects. Phytochem Rev. 2020;19(4):955–82. doi: https://dx.doi.org/10.1007/s11101-020-09695-4.  
51. Kumar S, Singh B. Traditional uses of Grewia spp. In: Elsevier; 2022. p.203–19. doi: https://dx.doi.org/10.1016/B978-0-323-85591-4.00017-9.  
52. Almas K. Effect of Salvadora persica extract on dentin. J Contemp Dent Pract. 2003. 
53. Molina-Cortés A, Quimbaya M, Toro-Gomez A, Tobar-Tosse F. Bioactive compounds in sugarcane. Heliyon. 2023;9(2):e13276. doi: https://dx.doi.org/10.1016/j.heliyon.2023.e13276.